Protein Alignment CG2224 and Stambp

DIOPT Version :10

• Sequence 1: NP_651796.1
• Gene: CG2224 / 43617
• FlyBaseID: FBgn0039773
• Length: 420
• Species: Drosophila melanogaster
• Sequence 2: NP_077201.1
• Gene: Stambp / 70527
• MGIID: 1917777
• Length: 424
• Species: Mus musculus
• Alignment Length: 443
• Identity: 191/443 - (43%)
• Similarity: 265/443 - (59%)
• Gaps: 57/443 - (12%)

  Fly    11 GDVE--PQERMKHLSHCGNLIEVDKNMPVTRYYRSGTEMLRMANVYLREGNHENAFILYLRYMTL 73
            |||.  ||:|::.||..|:.:|:::::|..||||||.|::|||:||..|||.|:|||||.:|:||
Mouse     5 GDVSLPPQDRVRILSQLGSAVELNEDIPPRRYYRSGVEIIRMASVYSEEGNIEHAFILYNKYITL 69

  Fly    74 FIEKIRQHPDYGS-VKAEVRDINRKIKDEIMPTTEKLRAKLLTHYQREYEQFLASKEAERVKELE 137
            ||||:.:|.||.| :..|.:|..:|:|....|..|:|:.:||..|.:||||:...|:.|. :||.
Mouse    70 FIEKLPKHRDYKSAIIPEKKDAVKKLKSVAFPKAEELKTELLRRYTKEYEQYKERKKKEE-EELA 133

  Fly   138 R------ERERERER---QRQKEREKAGSSAIPSLIPANLHVLIDEGNQPSAPDLGLLDQVVYPN 193
            |      |.|:|::|   |:||:.|:....|...:|...   .:::.......:.|.:|
Mouse   134 RNIAIQQELEKEKQRVAQQKQKQLEQEQFHAFEEMIQRQ---ELEKERLKIVQEFGKVD------ 189

  Fly   194 DFPTGANRSLPG-SGLLLPAASEAAADKTTNS------------------KPSFDRNQKP---SY 236
                      || .|.|||...:...|...:|                  .|..||:.||   |.
Mouse   190 ----------PGPCGPLLPDLEKPCVDVAPSSPFSPTQTPDCNTGMRPAKPPVVDRSLKPGALSV 244

  Fly   237 NRTDSLLAGSLRLVYVPGDTMEVFLKLALANTSKNIETCGVLAGHLSQNQLYITHIITPQQQGTP 301
            ......:.| ||.:.||.:....||:||.|||:|.|||||||.|.|.:|:..|||::.|:|.|.|
Mouse   245 IENVPTIEG-LRHIVVPRNLCSEFLQLASANTAKGIETCGVLCGKLMRNEFTITHVLIPRQNGGP 308

  Fly   302 DSCNTMHEEQIFDVQDQMQLITLGWIHTHPTQTAFLSSVDLHTHCSYQIMMPEALAIVCAPKYNT 366
            |.|:|.:||:||.:||.:.|:|||||||||||||||||||||||||||:|:||::||||:||:..
Mouse   309 DYCHTENEEEIFFMQDDLGLLTLGWIHTHPTQTAFLSSVDLHTHCSYQMMLPESIAIVCSPKFQE 373

  Fly   367 TGFFILTPHYGLDYIAQCRQSGFHPHPNDPPLFMEAQHIRMDNQAKIKVIDLR 419
            ||||.|| .|||..|:.|||.|||||..|||||.:..|:.:.::. :.:.|||
Mouse   374 TGFFKLT-DYGLQEISTCRQKGFHPHGRDPPLFCDCSHVTVKDRI-VTITDLR 424

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2224	NP_651796.1	USP8_dimer	11..120	CDD:462647	53/111 (48%)
		MPN_AMSH_like	247..419	CDD:163697	100/171 (58%)
Stambp	NP_077201.1	Interaction with CHMP3. /evidence=ECO:0000250|UniProtKB:O95630	1..127		58/121 (48%)
		USP8_dimer	7..117	CDD:462647	51/109 (47%)
		Interaction with STAM. /evidence=ECO:0000250|UniProtKB:O95630	227..231		0/3 (0%)
		MPN_AMSH_like	254..424	CDD:163697	100/171 (58%)
		JAMM motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01182	335..348		12/12 (100%)