DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2224 and Stambpl1

DIOPT Version :9

Sequence 1:	NP_001263108.1	Gene:	CG2224 / 43617	FlyBaseID:	FBgn0039773	Length:	420	Species:	Drosophila melanogaster
Sequence 2:	NP_001108520.1	Gene:	Stambpl1 / 687696	RGDID:	1583011	Length:	436	Species:	Rattus norvegicus

Alignment Length:	421	Identity:	177/421 - (42%)
Similarity:	247/421 - (58%)	Gaps:	22/421 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 VEPQERMKHLSHCGNLIEVDKNMPVTRYYRSGTEMLRMANVYLREGNHENAFILYLRYMTLFIEK 77
            :.|:||::.||..|..|.:::::...||:|||.||.|||:|||.|||.||||:||.:::|||:||
  Rat    24 LSPEERVRALSKLGCNISINEDITPRRYFRSGVEMERMASVYLEEGNLENAFVLYNKFITLFVEK 88

  Fly    78 IRQHPDYGSVKA-EVRDINRKIKDEIMPTTEKLRAKLLTHYQREYEQFLASK---EAERVKELER 138
            :..|.||..... |.:||.:|:|:...|.|::|:..||..|..||:::|.||   :||.:|:||.
  Rat    89 LPSHRDYQQCAVPEKQDIMKKLKEIAFPRTDELKTDLLRKYNIEYQEYLQSKNKYKAEILKKLEH 153

  Fly   139 ERERERERQR--QKEREKAGSSAIPSLIPANLHVLIDEGNQPSAPDLGLLDQVVYPND------F 195
            :|..|.||||  |..:::..|..............:..|.......|.|.:|    .|      |
  Rat   154 QRLIEAERQRIAQMRQQQLESEQFLFFEDQLKKQELARGQTRGQDSLVLSEQ----TDGSGLSCF 214

  Fly   196 PTGANRSLPGSGLLLPAASEAAADKTTNSKPSFDRNQKP--SYNRTDSLLAGSLRLVYVPGDTME 258
            .|..|.||.......|..|:..  ...|..|..:|..||  :.:...:|:...||.|.:..|...
  Rat   215 STHQNNSLRNVFADHPQKSDVC--DLANYSPPVNRALKPAATLSAVQNLVVEGLRCVVLSRDLCH 277

  Fly   259 VFLKLALANTSKNIETCGVLAGHLSQNQLYITHIITPQQQGTPDSCNTMHEEQIFDVQDQMQLIT 323
            .||.||.:||.:.|||||:|.|.|:.|:..|||::.|:|...||.|:..:.|::|.||||..|:|
  Rat   278 KFLLLADSNTVRGIETCGILCGKLTHNEFTITHVVVPKQSAGPDYCDVENVEELFSVQDQHGLLT 342

  Fly   324 LGWIHTHPTQTAFLSSVDLHTHCSYQIMMPEALAIVCAPKYNTTGFFILTPHYGLDYIAQCRQSG 388
            ||||||||||||||||||||||||||:|:|||:||||:||:..||.|.|| :.|:..::.|::.|
  Rat   343 LGWIHTHPTQTAFLSSVDLHTHCSYQLMLPEAIAIVCSPKHKDTGIFRLT-NAGMLEVSTCKKKG 406

  Fly   389 FHPHPNDPPLFMEAQHIRMDNQAKIKVIDLR 419
            ||||..||.||....|: :....|..|:|||
  Rat   407 FHPHTKDPKLFSICSHV-LVKDIKTTVLDLR 436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2224	NP_001263108.1	USP8_dimer	16..119	CDD:286108	47/103 (46%)
CG2224	NP_001263108.1	MPN_AMSH_like	247..419	CDD:163697	91/171 (53%)
Stambpl1	NP_001108520.1	USP8_dimer	28..129	CDD:401063	46/100 (46%)
		OmpH	101..>186	CDD:397844	29/84 (35%)
		MPN_AMSH_like	266..436	CDD:163697	91/171 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340541
Domainoid	1	1.000	147	1.000	Domainoid score	I4387
eggNOG	1	0.900	-	-		E1_COG1310
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	325	1.000	Inparanoid score	I2401
OMA	1	1.010	-	-		QHG49824
OrthoDB	1	1.010	-	-		D411229at2759
OrthoFinder	1	1.000	-	-		FOG0002716
OrthoInspector	1	1.000	-	-		otm45554
orthoMCL	1	0.900	-	-		OOG6_103166
Panther	1	1.100	-	-	O	PTHR12947
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1584
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.810