Protein Alignment CG2224 and STAMBPL1

DIOPT Version :10

• Sequence 1: NP_651796.1
• Gene: CG2224 / 43617
• FlyBaseID: FBgn0039773
• Length: 420
• Species: Drosophila melanogaster
• Sequence 2: NP_065850.1
• Gene: STAMBPL1 / 57559
• HGNCID: 24105
• Length: 436
• Species: Homo sapiens
• Alignment Length: 429
• Identity: 178/429 - (41%)
• Similarity: 251/429 - (58%)
• Gaps: 38/429 - (8%)

  Fly    13 VEPQERMKHLSHCGNLIEVDKNMPVTRYYRSGTEMLRMANVYLREGNHENAFILYLRYMTLFIEK 77
            :.|:||::.||..|..|.:.:::...||:|||.||.|||:|||.|||.||||:||.:::|||:||
Human    24 LSPEERVRALSKLGCNITISEDITPRRYFRSGVEMERMASVYLEEGNLENAFVLYNKFITLFVEK 88

  Fly    78 IRQHPDYGSVKA-EVRDINRKIKDEIMPTTEKLRAKLLTHYQREYEQFLASK---EAERVKELER 138
            :..|.||..... |.:||.:|:|:...|.|::|:..||..|..||:::|.||   :||.:|:||.
Human    89 LPNHRDYQQCAVPEKQDIMKKLKEIAFPRTDELKNDLLKKYNVEYQEYLQSKNKYKAEILKKLEH 153

  Fly   139 ER--ERERERQRQKEREKAGSSAIPSLIPANLHVLIDEGNQPSAPDLGLLDQVVYPND------F 195
            :|  |.||:|..|..:::..|..............:..|...|....||.:|:    |      |
Human   154 QRLIEAERKRIAQMRQQQLESEQFLFFEDQLKKQELARGQMRSQQTSGLSEQI----DGSALSCF 214

  Fly   196 PTGANRSLPGSGLLLPAASEAAADKTTNSKPSFDRNQKPSYNR----------TDSLLAGSLRLV 250
            .|..|.||          ....||:...|..:...:..|..||          ..:|:...||.|
Human   215 STHQNNSL----------LNVFADQPNKSDATNYASHSPPVNRALTPAATLSAVQNLVVEGLRCV 269

  Fly   251 YVPGDTMEVFLKLALANTSKNIETCGVLAGHLSQNQLYITHIITPQQQGTPDSCNTMHEEQIFDV 315
            .:|.|....||:||.:||.:.|||||:|.|.|:.|:..|||:|.|:|...||.|:..:.|::|:|
Human   270 VLPEDLCHKFLQLAESNTVRGIETCGILCGKLTHNEFTITHVIVPKQSAGPDYCDMENVEELFNV 334

  Fly   316 QDQMQLITLGWIHTHPTQTAFLSSVDLHTHCSYQIMMPEALAIVCAPKYNTTGFFILTPHYGLDY 380
            |||..|:|||||||||||||||||||||||||||:|:|||:||||:||:..||.|.|| :.|:..
Human   335 QDQHDLLTLGWIHTHPTQTAFLSSVDLHTHCSYQLMLPEAIAIVCSPKHKDTGIFRLT-NAGMLE 398

  Fly   381 IAQCRQSGFHPHPNDPPLFMEAQHIRMDNQAKIKVIDLR 419
            ::.|::.|||||..:|.||...:|: :....||.|:|||
Human   399 VSACKKKGFHPHTKEPRLFSICKHV-LVKDIKIIVLDLR 436

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2224	NP_651796.1	USP8_dimer	11..120	CDD:462647	48/107 (45%)
		MPN_AMSH_like	247..419	CDD:163697	93/171 (54%)
STAMBPL1	NP_065850.1	USP8_dimer	28..132	CDD:462647	47/103 (46%)
		GBP_C	<120..198	CDD:293879	23/77 (30%)
		MPN_AMSH_like	266..436	CDD:163697	93/171 (54%)
		JAMM motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01182	347..360		12/12 (100%)