DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2224 and stambpl1

DIOPT Version :9

Sequence 1:	NP_001263108.1	Gene:	CG2224 / 43617	FlyBaseID:	FBgn0039773	Length:	420	Species:	Drosophila melanogaster
Sequence 2:	NP_989010.1	Gene:	stambpl1 / 394606	XenbaseID:	XB-GENE-5752500	Length:	429	Species:	Xenopus tropicalis

Alignment Length:	438	Identity:	171/438 - (39%)
Similarity:	251/438 - (57%)	Gaps:	61/438 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 VEPQERMKHLSHCGNLIEVDKNMPVTRYYRSGTEMLRMANVYLREGNHENAFILYLRYMTLFIEK 77
            :.|:||::.||..|..|.:::::...||:|||.||.|||:|||.|||.||||:||.:::|||:||
Frog    22 LSPEERVRALSKLGCNITINEDITPRRYFRSGVEMERMASVYLEEGNLENAFVLYNKFITLFVEK 86

  Fly    78 IRQHPDYGSVK-AEVRDINRKIKDEIMPTTEKLRAKLLTHYQREYEQFLA---SKEAERVKELER 138
            :..|.||...: .|.:||.:|:|:...|.|::|:..||..|..||:::|.   .::||.:|:||:
Frog    87 LPGHRDYQQYEIPEKQDILKKLKEVAFPRTDELKKDLLKKYNLEYQEYLQGVHKRKAECLKKLEQ 151

  Fly   139 ERERERE-------RQRQKEREK--------------------AGSSAIPSLIPANLHVLIDEGN 176
            ::..|.|       ||:|.:.|:                    ..:..:|..|...:...|....
Frog   152 QQLIEAEKKRLAQIRQQQIQTEQFSFFEDQLRKQDQVRDQLKIKDAPKVPEQIDGGMVTCISNAK 216

  Fly   177 QPSAPDLGLLDQVVYPNDFPTGANRSLPGSGLLLPAASEAAADKTTNSKPSFDRNQKPSYNRTDS 241
            ..........|..:|....|       |.:..|.|||:.:|.           :|:
Frog   217 SSCTEQAKRNDASIYTGQSP-------PVTRALKPAATLSAV-----------QNE--------- 254

  Fly   242 LLAGSLRLVYVPGDTMEVFLKLALANTSKNIETCGVLAGHLSQNQLYITHIITPQQQGTPDSCNT 306
             :...||.|.:|.|..:.||:||.||||:.|||||:|.|.|:.::..|||:|.|:|...||.|:.
Frog   255 -IVDGLRPVVLPRDLSQRFLQLAEANTSRGIETCGILCGKLTHDEFTITHVIVPKQSAGPDYCDM 318

  Fly   307 MHEEQIFDVQDQMQLITLGWIHTHPTQTAFLSSVDLHTHCSYQIMMPEALAIVCAPKYNTTGFFI 371
            .:.|::|:||||..|:|||||||||||||||||||||||||||:|:|||:||||:||:|.||.|.
Frog   319 ENVEELFNVQDQHNLLTLGWIHTHPTQTAFLSSVDLHTHCSYQLMLPEAIAIVCSPKHNDTGIFR 383

  Fly   372 LTPHYGLDYIAQCRQSGFHPHPNDPPLFMEAQHIRMDNQAKIKVIDLR 419
            || ..|:..::.|::.|||||..:|..|...:|:.:.: |.|.|:|||
Frog   384 LT-SAGMLEVSACKKKGFHPHSKEPRQFNTCRHVTVQD-AGITVLDLR 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2224	NP_001263108.1	USP8_dimer	16..119	CDD:286108	47/103 (46%)
CG2224	NP_001263108.1	MPN_AMSH_like	247..419	CDD:163697	94/171 (55%)
stambpl1	NP_989010.1	USP8_dimer	26..127	CDD:401063	46/100 (46%)
		Nop25	132..>207	CDD:401675	14/74 (19%)
		MPN_AMSH_like	259..429	CDD:163697	94/171 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	146	1.000	Domainoid score	I4514
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	327	1.000	Inparanoid score	I2431
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D411229at2759
OrthoFinder	1	1.000	-	-		FOG0002716
OrthoInspector	1	1.000	-	-		otm48652
Panther	1	1.100	-	-	O	PTHR12947
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1584
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.160