Protein Alignment CG2224 and Stambp

DIOPT Version :10

• Sequence 1: NP_651796.1
• Gene: CG2224 / 43617
• FlyBaseID: FBgn0039773
• Length: 420
• Species: Drosophila melanogaster
• Sequence 2: NP_612540.1
• Gene: Stambp / 171565
• RGDID: 619963
• Length: 424
• Species: Rattus norvegicus
• Alignment Length: 434
• Identity: 188/434 - (43%)
• Similarity: 266/434 - (61%)
• Gaps: 49/434 - (11%)

  Fly    15 PQERMKHLSHCGNLIEVDKNMPVTRYYRSGTEMLRMANVYLREGNHENAFILYLRYMTLFIEKIR 79
            ||:|::.||..|:.:|:::::|..||:|||.|::|||::|..|||.|:|||||.:|:||||||:.
  Rat    11 PQDRVRILSQLGSAVELNEDIPPRRYFRSGVEIIRMASIYSEEGNIEHAFILYNKYITLFIEKLP 75

  Fly    80 QHPDYGS-VKAEVRDINRKIKDEIMPTTEKLRAKLLTHYQREYEQFLASKEAERVKELER----- 138
            :|.||.| :..|.:|..:|:|:...|..|:|:.:||..|.:||||:...|:.|. :||.|
  Rat    76 KHRDYKSAIIPEKKDAVKKLKNVAFPKAEELKTELLKRYTKEYEQYKERKKKEE-EELARNIAIQ 139

  Fly   139 -ERERERER---QRQKEREKAGSSAIPSLI------PANLHVL-----IDEGN-QPSAPDLGLLD 187
             |.|:|::|   |:||:.|:....|...:|      ...|.::     :|.|. .|..|||....
  Rat   140 QELEKEKQRVAQQKQKQLEQEQFHAFEKMIQKQELEKERLKIVQEFGKVDPGPCGPLLPDLEKPC 204

  Fly   188 QVVYPNDFPTGANRSLPGSGLLLPAASEAAADKTTNSKPS----FDRNQKP---SYNRTDSLLAG 245
            ..|.|:.                |.:....:|..|..:|:    .||:.||   |.......:.|
  Rat   205 VDVAPSS----------------PFSPTQTSDCNTTLRPAKPPVVDRSLKPGALSVIENVPTIEG 253

  Fly   246 SLRLVYVPGDTMEVFLKLALANTSKNIETCGVLAGHLSQNQLYITHIITPQQQGTPDSCNTMHEE 310
             ||.:.||.:....||:||.|||:|.|||||||.|.|.:|:..|||::.|:|.|.||.|:|.:||
  Rat   254 -LRHIVVPRNLCSEFLQLASANTAKGIETCGVLCGKLMRNEFTITHVLIPRQNGGPDYCHTENEE 317

  Fly   311 QIFDVQDQMQLITLGWIHTHPTQTAFLSSVDLHTHCSYQIMMPEALAIVCAPKYNTTGFFILTPH 375
            :||.:||.:.|:|||||||||||||||||||||||||||:|:||::||||:||:..||||.|| .
  Rat   318 EIFFMQDDLGLLTLGWIHTHPTQTAFLSSVDLHTHCSYQMMLPESIAIVCSPKFQETGFFKLT-D 381

  Fly   376 YGLDYIAQCRQSGFHPHPNDPPLFMEAQHIRMDNQAKIKVIDLR 419
            |||..|:.|||.|||||..|||||.:..|:.:.::. :.:.|||
  Rat   382 YGLQEISTCRQKGFHPHGRDPPLFCDCSHVTVKDRI-VTITDLR 424

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2224	NP_651796.1	USP8_dimer	11..120	CDD:462647	48/105 (46%)
		MPN_AMSH_like	247..419	CDD:163697	100/171 (58%)
Stambp	NP_612540.1	Interaction with CHMP3. /evidence=ECO:0000250|UniProtKB:O95630	1..127		53/115 (46%)
		USP8_dimer	7..117	CDD:462647	48/105 (46%)
		Interaction with STAM. /evidence=ECO:0000250|UniProtKB:O95630	227..231		1/3 (33%)
		MPN_AMSH_like	254..424	CDD:163697	100/171 (58%)
		JAMM motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01182	335..348		12/12 (100%)