DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2224 and Stambp

DIOPT Version :9

Sequence 1:	NP_001263108.1	Gene:	CG2224 / 43617	FlyBaseID:	FBgn0039773	Length:	420	Species:	Drosophila melanogaster
Sequence 2:	NP_612540.1	Gene:	Stambp / 171565	RGDID:	619963	Length:	424	Species:	Rattus norvegicus

Alignment Length:	434	Identity:	188/434 - (43%)
Similarity:	266/434 - (61%)	Gaps:	49/434 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 PQERMKHLSHCGNLIEVDKNMPVTRYYRSGTEMLRMANVYLREGNHENAFILYLRYMTLFIEKIR 79
            ||:|::.||..|:.:|:::::|..||:|||.|::|||::|..|||.|:|||||.:|:||||||:.
  Rat    11 PQDRVRILSQLGSAVELNEDIPPRRYFRSGVEIIRMASIYSEEGNIEHAFILYNKYITLFIEKLP 75

  Fly    80 QHPDYGS-VKAEVRDINRKIKDEIMPTTEKLRAKLLTHYQREYEQFLASKEAERVKELER----- 138
            :|.||.| :..|.:|..:|:|:...|..|:|:.:||..|.:||||:...|:.|. :||.|
  Rat    76 KHRDYKSAIIPEKKDAVKKLKNVAFPKAEELKTELLKRYTKEYEQYKERKKKEE-EELARNIAIQ 139

  Fly   139 -ERERERER---QRQKEREKAGSSAIPSLI------PANLHVL-----IDEGN-QPSAPDLGLLD 187
             |.|:|::|   |:||:.|:....|...:|      ...|.::     :|.|. .|..|||....
  Rat   140 QELEKEKQRVAQQKQKQLEQEQFHAFEKMIQKQELEKERLKIVQEFGKVDPGPCGPLLPDLEKPC 204

  Fly   188 QVVYPNDFPTGANRSLPGSGLLLPAASEAAADKTTNSKPS----FDRNQKP---SYNRTDSLLAG 245
            ..|.|:.                |.:....:|..|..:|:    .||:.||   |.......:.|
  Rat   205 VDVAPSS----------------PFSPTQTSDCNTTLRPAKPPVVDRSLKPGALSVIENVPTIEG 253

  Fly   246 SLRLVYVPGDTMEVFLKLALANTSKNIETCGVLAGHLSQNQLYITHIITPQQQGTPDSCNTMHEE 310
             ||.:.||.:....||:||.|||:|.|||||||.|.|.:|:..|||::.|:|.|.||.|:|.:||
  Rat   254 -LRHIVVPRNLCSEFLQLASANTAKGIETCGVLCGKLMRNEFTITHVLIPRQNGGPDYCHTENEE 317

  Fly   311 QIFDVQDQMQLITLGWIHTHPTQTAFLSSVDLHTHCSYQIMMPEALAIVCAPKYNTTGFFILTPH 375
            :||.:||.:.|:|||||||||||||||||||||||||||:|:||::||||:||:..||||.|| .
  Rat   318 EIFFMQDDLGLLTLGWIHTHPTQTAFLSSVDLHTHCSYQMMLPESIAIVCSPKFQETGFFKLT-D 381

  Fly   376 YGLDYIAQCRQSGFHPHPNDPPLFMEAQHIRMDNQAKIKVIDLR 419
            |||..|:.|||.|||||..|||||.:..|:.:.::. :.:.|||
  Rat   382 YGLQEISTCRQKGFHPHGRDPPLFCDCSHVTVKDRI-VTITDLR 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2224	NP_001263108.1	USP8_dimer	16..119	CDD:286108	47/103 (46%)
CG2224	NP_001263108.1	MPN_AMSH_like	247..419	CDD:163697	100/171 (58%)
Stambp	NP_612540.1	Interaction with CHMP3. /evidence=ECO:0000250	1..127		53/115 (46%)
		USP8_dimer	8..115	CDD:401063	47/103 (46%)
		Interaction with STAM1. /evidence=ECO:0000250	227..231		1/3 (33%)
		MPN_AMSH_like	254..424	CDD:163697	100/171 (58%)
		JAMM motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01182	335..348		12/12 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340542
Domainoid	1	1.000	147	1.000	Domainoid score	I4387
eggNOG	1	0.900	-	-		E1_COG1310
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4719
Inparanoid	1	1.050	325	1.000	Inparanoid score	I2401
OMA	1	1.010	-	-		QHG49824
OrthoDB	1	1.010	-	-		D411229at2759
OrthoFinder	1	1.000	-	-		FOG0002716
OrthoInspector	1	1.000	-	-		otm45554
orthoMCL	1	0.900	-	-		OOG6_103166
Panther	1	1.100	-	-	LDO	PTHR12947
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1584
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.770