Protein Alignment AdoR and Taar7a

DIOPT Version :10

• Sequence 1: NP_651772.1
• Gene: AdoR / 43583
• FlyBaseID: FBgn0039747
• Length: 774
• Species: Drosophila melanogaster
• Sequence 2: NP_001010829.1
• Gene: Taar7a / 215856
• MGIID: 2685075
• Length: 358
• Species: Mus musculus
• Alignment Length: 341
• Identity: 96/341 - (28%)
• Similarity: 148/341 - (43%)
• Gaps: 74/341 - (21%)

  Fly    35 SPSSELNIPYTVFEVLVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVGALGIPFAI 99
            ||...| |.|.||. ..|.:::.||:||:......|:|....|:.:.|||.||.|||...:||:.
Mouse    43 SPGPRL-ILYAVFG-FGAALAVCGNLLVMTSILHFRQLHSPANFLVASLACADFLVGLTVMPFST 105

  Fly   100 LASM------GLPR-NLHACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSRNVRTRTAI 157
            :.|:      |... ..|:| |..|    .|..|||.|..:|||||.|:..|:.|........:.
Mouse   106 VRSVEGCWYFGESYCKFHSC-FEGS----FCYSSIFHLCFISVDRYIAVSDPLTYPTRFTASVSG 165

  Fly   158 FIISMCWVAGTIVGFLPLF-------------------GWHADVNHNQECLFVEVMDYNYLVFLY 203
            ..|:..|:...|..|..|:                   |....|  ||..:|:     |:|:||
Mouse   166 KCITFSWLLSIIYSFSLLYTGANEAGLEDLVSVLTCVGGCQIAV--NQSWVFI-----NFLLFL- 222

  Fly   204 FATIITPALLMLAFYTHIYRVIIKQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLRVL 268
                 .|.|:|:..|:.|:.:..:|.:.|..|  :...:|.|.:...:|.
Mouse   223 -----IPTLVMMTVYSKIFLIAKQQAQNIEKM--SKQTARASESYKDRVA--------------- 265

  Fly   269 GAARKRDVKATQNLSIIVLFFMICWIPLYTINCIKA---FCPDCYVHPKLTLFCIILSHLNSAVN 330
                ||:.||.:.|.|.|..|::.|:|.:..:.|.|   |....||:..|    :.:::.|||:|
Mouse   266 ----KRERKAAKTLGIAVAAFLLSWLPYFIDSIIDAFLGFITPTYVYEIL----VWIAYYNSAMN 322

  Fly   331 PVLYAYHLKDFRAALK 346
            |::||:....||.|:|
Mouse   323 PLIYAFFYPWFRKAIK 338

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tmA_Adenosine_R	42..345	CDD:341316	91/331 (27%)
		TM helix 1	43..69	CDD:341316	8/25 (32%)
		TM helix 2	76..103	CDD:341316	11/26 (42%)
		TM helix 3	112..142	CDD:341316	14/29 (48%)
		TM helix 4	156..174	CDD:341316	4/17 (24%)
		TM helix 5	196..225	CDD:341316	9/28 (32%)
		TM helix 6	273..303	CDD:341316	10/29 (34%)
		TM helix 7	313..338	CDD:341316	8/24 (33%)
Taar7a	NP_001010829.1	7tm_GPCRs	49..337	CDD:475119	91/331 (27%)
		TM helix 1	50..74	CDD:320439	8/24 (33%)
		TM helix 2	83..105	CDD:320439	11/21 (52%)
		TM helix 3	121..143	CDD:320439	9/26 (35%)
		TM helix 4	166..182	CDD:320439	4/15 (27%)
		TM helix 5	210..233	CDD:320439	10/33 (30%)
		TM helix 6	272..294	CDD:320439	6/21 (29%)
		TM helix 7	305..330	CDD:320439	10/28 (36%)