Protein Alignment Tace and adam11

DIOPT Version :8

• Sequence 1: NP_733334.1
• Gene: Tace / 43558
• FlyBaseID: FBgn0039734
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: XP_021335948.1
• Gene: adam11 / 567145
• ZFINID: ZDB-GENE-070808-3
• Length: 788
• Species: Danio rerio
• Alignment Length: 603
• Identity: 139/604 (23%)
• Similarity: 226/604 (37%)
• Gaps: 143/604 (24%)

  Fly    57 TNPFNTIKEVEF--TTLGKNFRLILHPHRDVLHSKFRAYAVDADGNETVVHMDHDSFYSGRVFGE 119
            |:|.: :.::.|  ...|..|.|.|..:.|:|.|.:.....:.||...........:|.|.|.|.
Zfish    75 THPIH-LAQITFLVKAFGIPFVLDLELNHDLLSSNYVERHFEKDGQSFQTLGGEHCYYHGHVRGV 138

  Fly   120 LES--------SVRAHIEDGTMTMSIHLPEETYHIEPSWRHLPEAK--------KDT--MVAYKA 166
            ..|        .::....||..:..|    |..|......|  ::|        ||.  .|.|:.
Zfish   139 PRSWAALSTCHGLQGMFSDGNFSYGI----EPLHNSSDQTH--DSKIIEEDASIKDANIHVVYRM 197

  Fly   167 SDVKVHKNEAGATPKTC-----GYIKEGLELEDKEHGDTLDNELHTREKRQSDQYEYT-PTKTR- 224
            :|:::..:.:|:|..:.     ......:|....|..|.|     .|.|||..:...| .::|:
Zfish   198 ADIRLMPHFSGSTRNSSDSDINNDYPVSMETSQLELTDGL-----RRAKRQVRRGPRTVQSETKY 257

  Fly   225 CPLLLVADYRFFQEMGGGNTKTTINYLISLIDRVHKIYNDTVWQDRSDQEGFKGMGFVIKKIVVH 289
            ..||:|.||..|.:|...:.:|. |:..::::....||.:.                :..:||:
Zfish   258 VELLVVNDYDLFVQMRRSSPQTR-NFAKAVVNMADAIYKEQ----------------LNTRIVL- 304

  Fly   290 SEPTRLRGGEAHYNMIREKWDVRNLLEV-------------FSREYSHKDFCLAHLFTDLKFEGG 341
                          :..|.|..:|::.|             :.:|...:....|||.:...|:..
Zfish   305 --------------VAMETWSTQNMVSVGDDPLVTLRDFMKYRKENIKEKSDTAHLLSGRTFQSS 355

  Fly   342 ILGLAYVGSPRRNSVGGICTPEYFKNGYTLYLNSGLSSSRNHYGQRVITREADLVTAHEFGHNWG 406
            ..|.||        :.|||:|          ...|..:...:.|...||      .....|.|.|
Zfish   356 RSGTAY--------IEGICSP----------TRGGGVNEYGNVGPMAIT------LCQSLGQNLG 396

  Fly   407 SEHDPDIPECSPSASQG-----GSFLMYTYSVSGYDVNNKKFSPCSLRSIRKVLQAKSGRC-FSE 465
            ...:.|      .|:.|     ..:|......:||.: .:|||.||:....:.||...|.| |::
Zfish   397 MMWNKD------RATAGDCRCPDPWLGCIMEDTGYYL-PRKFSRCSIEEYIQFLQQGGGSCLFNK 454

  Fly   466 PEESF----CGNLRVEGDEQCDAG--LLGTEDNDSCCDKNCKLRRNQGAMCSDKNSPCCQNCQFM 524
            |.:..    |||..||..|:||.|  :..:....:|| |.|.|..:  ||||  |..||..|::.
Zfish   455 PNKLLDPPECGNGFVEQGEECDCGSQVDCSRAGGACC-KKCTLTHD--AMCS--NGLCCNRCKYE 514

  Fly   525 ASGMKCREAQYATCEQEARCTGAHAECPKSPAMADGTTCQE-RGQCRNGKCVPYCETQGLQSCMC 588
            ..|:.||:| ...|:....|:|..::||.:....||..|.. .|:|..|:    |:|:..|   |
Zfish   515 QRGVICRDA-VNDCDVPETCSGDSSKCPHNVHKLDGYMCDAGLGRCYGGR----CKTRDAQ---C 571

  Fly   589 DII--ADACKRCCRMSIN 604
            ..:  .:|..|.|...:|
Zfish   572 QALWGHNAADRMCYEKLN 589

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tace	NP_733334.1	Pep_M12B_propep	50..162	CDD:279848	26/125 (21%)
		ZnMc_TACE_like	223..470	CDD:239798	54/267 (20%)
		Reprolysin_2	244..456	CDD:290307	41/230 (18%)
		Disintegrin	477..552	CDD:278623	26/77 (34%)
		ADAM17_MPD	576..633	CDD:271205	8/32 (25%)
adam11	XP_021335948.1	Pep_M12B_propep	68..195	CDD:307618	27/127 (21%)
		Reprolysin	256..455	CDD:307535	52/262 (20%)
		Disintegrin	470..543	CDD:306668	27/79 (34%)
		ACR	547..688	CDD:214743	14/51 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030		avgDist	Average_Evolutionary_Distance	R4147
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.030