DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dgt1 and LOC110440037

DIOPT Version :9

Sequence 1:	NP_001287595.1	Gene:	dgt1 / 43529	FlyBaseID:	FBgn0039710	Length:	589	Species:	Drosophila melanogaster
Sequence 2:	XP_021334490.1	Gene:	LOC110440037 / 110440037	-ID:	-	Length:	922	Species:	Danio rerio

Alignment Length:	765	Identity:	151/765 - (19%)
Similarity:	236/765 - (30%)	Gaps:	306/765 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 EQIH-SELVKIKYCANPTYECSLMRIEGYEYCIRHILRDPRSNFRQCSHVYS-NGRKCINAVAKY 92
            :.|| ||:.....|:.....|...|:.||.:||||:|.|..:.|:||.:|.. |.::|.|.:.|.
Zfish     5 KHIHFSEVDNKPLCSYSPKLCKQRRLNGYAFCIRHVLEDKTAPFKQCEYVAKYNSQRCTNPIPKA 69

  Fly    93 DNKKELILTTLCFEHNR------QTQLQKTHMNVGRIRSRVETNETLLHSLSSHINVED-----I 146
            :.::      .|..|.:      :.:.:|....:..:|||.......|:.....:.:.|     .
Zfish    70 EERR------YCNSHLQVLGFIPKKERKKKQDGLEEVRSRAHVESVALNITVPSLALRDTNGLPA 128

  Fly   147 KPEVKKIE----RDDDEIDVVSPHVTPFVTQDHRNSIGHVVESSRKRRRILDYASDSSSNDADPP 207
            .|...::.    .|.|.:|       ||...:..:.    ||.|..:|.....:|...::.....
Zfish   129 SPPCSRLTPMPLLDSDLLD-------PFAFYEEDSD----VEESLLQRPAQRSSSKRKASSTPVI 182

  Fly   208 CLRNTAQ----DIEFYESDHESI-----------------------------------------D 227
            .||.||:    |||.:.:..||.                                         :
Zfish   183 GLRVTARDLEPDIEHFSAVTESCTLPSSPPPPPPSPPQPSQHTERPTYAPLGTVQTLLCKPAPPE 247

  Fly   228 SEDDDPLKHAG--------------------------VFTRAEAVKIAETKLIKLQGLYR----- 261
            |....||..||                          |..|..|.......|::||.|.:
Zfish   248 SASSVPLPPAGLQNQPVIWRPASPRPLSAHDCPQPRSVALRPAAFTAPPVCLLRLQHLVQLYANR 312

  Fly   262 -------------------------------------------EQISYLQNVLRQRRR------- 276
                                                       .|.|.....|.:|.|
Zfish   313 QREHGDLFPHLGLDWSEDSADDEDTEELVPLLPQAWRLQERSPHQSSSSDKPLSRRARLAQLCSY 377

  Fly   277 ---KYLHDIRRERELYCSIHDQLKDTPHERKLYEQLKA-LNSYHRRQGVEAVLYKKLKEKRARDA 337
               :|.|..||:|..          :.|.|..|...|| |::..:.....|.|.:||  .|:...
Zfish   378 LQERYKHLCRRDRAA----------SRHSRYRYAFRKALLHAASKDPDCTAQLIQKL--SRSSQT 430

  Fly   338 LYAAKSSSNPK-----CVFTEGGVKCGERTLPCCKHCRKHILEDKRQVLFRACGVE-RSGVVCQE 396
            ...::|::..|     |..:..|..|....||..:||.:|||.::.|.||.:|... ..|..|..
Zfish   431 SSCSRSAAPHKYERTACTGSTKGQSCSNTALPFSRHCFQHILLNRSQQLFSSCTARFADGQQCSV 495

  Fly   397 PVASILEDSSCVLHLTVAPAKRQYIQKFYEVPSTPPVESIFAAGRGLDNFVGED----------- 450
            ||..|       .|.|  |...::.:|                   :|||:..|
Zfish   496 PVFDI-------THQT--PLCDEHAKK-------------------MDNFLRGDGHRRSQQQQQR 532

  Fly   451 -PRNE--------------------PQ-------PEGDDLLDFAN-----------GIFDFDLDG 476
             ||.:                    ||       |:|:.|:...:           ...:...|.
Zfish   533 RPRKKTKPPALTKKHKKKRRRGPRRPQKPIPPAVPQGNLLMPSLSLPTHHAHVRSPSTPELSADE 597

  Fly   477 V-DDLANSLDDDYSMFLDMDSDLGLAIED--DGVESDPVDLGLEEEGDGGSNDSVGPAESQAQDN 538
            : ||:||.:.       |:.:||.|..||  |.:...|.||                     ||
Zfish   598 LPDDIANEMP-------DIPNDLELNQEDFSDVLPRLPDDL---------------------QD- 633

  Fly   539 LIADNFELEEPSVQDNNELNFDIDESESNVNEVLRLLEGIEHMPWFDALM 588
                 |:|.|..   |.||....:|:|    |::|.|:.:...|  |:|:
Zfish   634 -----FDLFEGK---NGELLPTTEEAE----ELVRALQAMGSYP--DSLV 669

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dgt1	NP_001287595.1	zf-C3Hc3H	42..107	CDD:290602	20/65 (31%)
dgt1	NP_001287595.1	zf-C3Hc3H	349..411	CDD:290602	19/62 (31%)
LOC110440037	XP_021334490.1	zf-C3Hc3H	18..79	CDD:316414	20/66 (30%)
LOC110440037	XP_021334490.1	zf-C3Hc3H	450..511	CDD:316414	21/69 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	49	1.000	Domainoid score	I11822
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	92	1.000	Inparanoid score	I5078
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172254at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.060