Protein Alignment Usp1 and USP46

DIOPT Version :10

• Sequence 1: NP_651687.3
• Gene: Usp1 / 43462
• FlyBaseID: FBgn0028476
• Length: 1078
• Species: Drosophila melanogaster
• Sequence 2: NP_073743.2
• Gene: USP46 / 64854
• HGNCID: 20075
• Length: 366
• Species: Homo sapiens
• Alignment Length: 564
• Identity: 96/564 - (17%)
• Similarity: 151/564 - (26%)
• Gaps: 280/564 - (49%)

  Fly   269 GSSSNEIE-----SQEPQSHQYYGPNGGSNAAGAGAGLNGSAAALNHAPSMGTLCNIGNSCYLNS 328
            |::::.:|     .|.|.:..|:|                             |.|.||:||.||
Human    13 GTNASALEKDIGPEQFPINEHYFG-----------------------------LVNFGNTCYCNS 48

  Fly   329 VVYTLRFAPHFLHNLHHLIQDLNVVQQTIVRQQTARSASLGKNVSAAQLEHARSWSSKDLATSTD 393
            |:..|.|...|..|:                                            ||....
Human    49 VLQALYFCRPFRENV--------------------------------------------LAYKAQ 69

  Fly   394 QYSGQNGGVNSGNGGSGSSKSTHQSVTEKLHELYNNLHGNEMADSTEPYHADTLLHAIQDVNATF 458
            |...:|                   :...|.:|::::...:......|  ....:..::..|..|
Human    70 QKKKEN-------------------LLTCLADLFHSIATQKKKVGVIP--PKKFISRLRKENDLF 113

  Fly   459 EGNQQQDAHEFLMCVLNCIRETNQSLIKAIGECPEVIANGYIANPDEVDTGEGQDRTDSTASQNL 523
            :...||||||||..:||.|.:..|...|                         |::.
Human   114 DNYMQQDAHEFLNYLLNTIADILQEEKK-------------------------QEKQ-------- 145

  Fly   524 NAGNGSLATSQTTTTKTSFFSRKSKRKDEVKPSKSTRVQSPLKENSPTAGGITGAGTAHATANSL 588
               ||.|                          |:..:..|.:.|.|
Human   146 ---NGKL--------------------------KNGNMNEPAENNKP------------------ 163

  Fly   589 FYLNTVDLSGASSTSGSASTSASGVVSTSAALPTPPQATKYSSDDEMNSATVLKDKMRLEERIRE 653
                                                                             
Human   164 ----------------------------------------------------------------- 163

  Fly   654 LNLNFFSSDFEGIVVLTTKCLSCETITRQKQGMLDISVPVPISGYDNADLQDKPSTYIQNSCIT- 717
             .|.:....|:|.:...|:||:|||::.:.:..||:||.|.                 ||:.||
Human   164 -ELTWVHEIFQGTLTNETRCLNCETVSSKDEDFLDLSVDVE-----------------QNTSITH 210

  Fly   718 -------KEYFRGENKYSCNQCTGYTEAIRSISYEVLPRLLVIQLNRFSGGMEKVSTYVPTTF-- 773
                   .|....|.||.|..|....||.:.:..:.||.:|.:.|.||. .||::..|...::
Human   211 CLRDFSNTETLCSEQKYYCETCCSKQEAQKRMRVKKLPMILALHLKRFK-YMEQLHRYTKLSYRV 274

  Fly   774 ----TLPCFCATCCELGEGNKLHVYKLYSVITHVGATLTVGHYI 813
                .|..|..:...:   |...:|.|.:|:.|.|:....||||
Human   275 VFPLELRLFNTSSDAV---NLDRMYDLVAVVVHCGSGPNRGHYI 315

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp1	NP_651687.3	Peptidase_C19	308..819	CDD:470612	90/520 (17%)
USP46	NP_073743.2	Peptidase_C19G	36..363	CDD:239128	91/541 (17%)