DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp1 and Usp1

DIOPT Version :9

Sequence 1:	NP_001263061.1	Gene:	Usp1 / 43462	FlyBaseID:	FBgn0028476	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	NP_001015015.1	Gene:	Usp1 / 313387	RGDID:	1306461	Length:	784	Species:	Rattus norvegicus

Alignment Length:	902	Identity:	199/902 - (22%)
Similarity:	340/902 - (37%)	Gaps:	224/902 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   229 ARSSRKRTNTMSL--YDRR-------FQTTTEERRVANGYGGNAARSVTGSSSNEIESQEPQSHQ 284
            :|.|..:.|.:||  :.::       |..:.|:...|:.|.|:....|..::.:...|.|.:.
  Rat    13 SRGSPSKKNRLSLKFFQKKETKRALDFTDSQEDEEKASEYRGSEIDQVVPAAQSSPVSCEKRE-- 75

  Fly   285 YYGPNGGSNAAGAGAGLNGSAAALNHAPSMGTLCNIGNSCYLNSVVYTLRFAPHFLHNLHHLIQD 349
                                    |..|.:| |.|:||:|||||::..|.|.|.|...:.||
  Rat    76 ------------------------NLLPFVG-LNNLGNTCYLNSILQVLYFCPGFKAGVKHL--- 112

  Fly   350 LNVVQQTIVRQQTARSASLGKNVSAAQLEHARSW----SSKDLATSTDQYSGQNGGVNSGNGGSG 410
            .|::.:   :::..:..|:.|:..:.:.:...|:    |.:.|..|.:|.             ..
  Rat   113 FNIISR---KKEALKDDSIQKDKGSCKEDPLASYELICSLQSLIISVEQL-------------QA 161

  Fly   411 SSKSTHQSVTEKLHELYNNLHGNEMADSTEPYHADTLLHAIQDVNATFEGNQQQDAHEFLMCVLN 475
            |.....:..|::|              :|:|..   ||:.::::|..:||..|.||.|.|.|:|.
  Rat   162 SFLLNPEKYTDEL--------------ATQPRR---LLNTLRELNPMYEGYLQHDAQEVLQCILG 209

  Fly   476 CIRETNQSL----IKAIGECPEVIANGYIANPDEVDTGEGQDRTDSTAS-----QNLNAGN---- 527
            .|:||.|.|    ||.:.|....:....:..  |...|.....||||.:     :.|..||
  Rat   210 NIQETCQLLKKEEIKNLTEFSSKVEEKSLQK--EETGGISSTETDSTRNLDDLKEQLPKGNWKRK 272

  Fly   528 -----GSL-------------------------ATSQTTTTKTSFFSRKSKRKDEVKPS-KSTRV 561
                 |::                         ||..|.........:.....:..||| |.::|
  Rat   273 SDGESGNMKKKVKLSRESQPLEENQRQTRSKRKATGDTLEASPKIIPKCVSENESAKPSQKKSKV 337

  Fly   562 Q----SPLKENSPTAGGITGAG--TAHATANSLFYLNTVDLSGASSTSGSAST-SASGVVSTSAA 619
            :    .|..:...........|  |.:..:.....:|..||.......|..:| :.||..|..::
  Rat   338 KINWLKPATKQPSILSKFCSLGKITTNQRSKGQPKVNEGDLEEDLEKDGRDNTVNGSGPASPGSS 402

  Fly   620 LPTPPQATKYSSDDEMNSATVLKDKMRLEERIRELNLNFFSSDFEGIVVLTTKCLSCETITRQKQ 684
            : ||..:::..|               :.:...::........|:|.:||.|:||.||::|.:::
  Rat   403 V-TPVDSSEAKS---------------INKGAEQIGFELVEKLFQGQLVLRTRCLECESLTERRE 451

  Fly   685 GMLDISVPVPISGY----DNADLQDKPSTYIQ------NSCITKEYFRGENKYSCNQCTGYTEAI 739
            ...||||||.....    :::::..:|.|.::      :...:.|...||:||.|..|..||||.
  Rat   452 DFQDISVPVQEDELSKVEESSEISPEPKTEMKTLRWAISQFASVERIVGEDKYFCENCHHYTEAE 516

  Fly   740 RSISYEVLPRLLVIQLNRFS----------GGMEKVSTYVPTTFTLPCFCATCCELGEGNKLHV- 793
            ||:.::.:|.::.|.|..|:          ||:.|::|.:.|...|        .|.|.:....
  Rat   517 RSLLFDKMPEVITIHLKCFAASGLEFDCYGGGLSKINTPLLTPLKL--------SLEEWSTKPTN 573

  Fly   794 --YKLYSVITHVGATLTVGHYIAYTCFLDLASDYVNCPKDRRNTMTNSQTMASQAVPSNENAAPN 856
              |.|::|:.|.|.|::.|||.|.....||.|    ...|:.|.:.:......:..|.||..|
  Rat   574 DSYGLFAVVMHSGITISSGHYTASVKVTDLNS----LELDKGNFVVDQMCEIGKPEPLNEEEA-- 632

  Fly   857 NGSSSVASTPVIAAASALASSGNILMKKM-----KFGRSKASSSGDMSKNVKQVNGIISKNITNG 916
            .|::......|.......|....:|.||.     ..|..|:.:..::.........::....|:.
  Rat   633 RGTAENYDDEVSIRVGGNAQPSKVLNKKNVEGIGLLGGQKSKADYELCSKASNPEKVVGTPFTDS 697

  Fly   917 IGKLSISTTCQGVNCCAMRLCCTQQTSSSNSTSCSDFSEESL-QNGSNSNLSFGGSGSTYPTGYG 980
                                 ...:|:.:|.|..||.|:||. |.|.|.      ||......|
  Rat   698 ---------------------RNSETNDTNGTQESDRSKESSDQTGINV------SGLENKISY- 734

  Fly   981 STGRGGVRANYAHGGPDPIWYMCDDDKIKAMTQREFEELLSPTRKITITPYLLFYAR 1037
                 .|::...:.|.   |.:.||.::|...:::|...|||:...|.|||||||.:
  Rat   735 -----VVQSLKEYEGK---WLLFDDSEVKVTEEKDFLNSLSPSTSPTSTPYLLFYKK 783

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp1	NP_001263061.1	Peptidase_C19	308..819	CDD:271592	136/588 (23%)
Usp1	NP_001015015.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21		2/7 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	33..54		5/20 (25%)
		Peptidase_C19	82..>253	CDD:271592	39/174 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	232..341		35/152 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	363..411		12/50 (24%)
		Peptidase_C19O	<424..599	CDD:239136	52/197 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	686..723		1/36 (3%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1864
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	135	1.000	Inparanoid score	I4478
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D210538at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto98051
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5721
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.870