Protein Alignment superdeath and ERAP2

DIOPT Version :10

• Sequence 1: NP_651674.3
• Gene: superdeath / 43444
• FlyBaseID: FBgn0039640
• Length: 999
• Species: Drosophila melanogaster
• Sequence 2: NP_071745.1
• Gene: ERAP2 / 64167
• HGNCID: 29499
• Length: 960
• Species: Homo sapiens
• Alignment Length: 960
• Identity: 313/960 - (32%)
• Similarity: 490/960 - (51%)
• Gaps: 98/960 - (10%)

  Fly    89 VCTSYHLRRLKAGHDDTPKYDR----DVRLPHSIRPLKYNITIEPQLSGNFTFAGSVQIRIRVLE 149
            |.:|||..............:|    ::|||..:.||.|::.:.|.|: :..|..|.:|.:.|..
Human    40 VPSSYHFTEDPGAFPVATNGERFPWQELRLPSVVIPLHYDLFVHPNLT-SLDFVASEKIEVLVSN 103

  Fly   150 DCYNITMHAEELNISRSDASVHRVQNNGEPEGDGLRI-----HKQYLVGAKQFFVIELYDKLLKD 209
            ....|.:|:::|.|:.:...........:| |..|::     |:|        ..:.:.:||...
Human   104 ATQFIILHSKDLEITNATLQSEEDSRYMKP-GKELKVLSYPAHEQ--------IALLVPEKLTPH 159

  Fly   210 VEYVVHLRFDGIIEDYLQGFYRSSYE-VHNETRWVASTQFQATDARRAFPCFDEPALKANFTLHI 273
            ::|.|.:.|...:.|..:|||:|:|. :..|||.:|.|.|:.|.||.||||||||..||||::.|
Human   160 LKYYVAMDFQAKLGDGFEGFYKSTYRTLGGETRILAVTDFEPTQARMAFPCFDEPLFKANFSIKI 224

  Fly   274 ARPRNMTTISNMPIVSSNDHATMPSYVWDHFAESLPMSTYLVAYAISDFTHI----SSG-NFAVW 333
            .|......:||||.|.:.:  .....:.|||..::.||||||||.:.||..:    ||| ..:::
Human   225 RRESRHIALSNMPKVKTIE--LEGGLLEDHFETTVKMSTYLVAYIVCDFHSLSGFTSSGVKVSIY 287

  Fly   334 ARADAIKSAEYALSVGPRILTFLQDFFNVTFPLPKIDMIALPEFQAGAMENWGLITFRETAMLYD 398
            |..|......|||....::|.|.:.:|::.:||.|:|:||:|:|..||||||||||:|||::|:|
Human   288 ASPDKRNQTHYALQASLKLLDFYEKYFDIYYPLSKLDLIAIPDFAPGAMENWGLITYRETSLLFD 352

  Fly   399 PGVATANNKQRVASVVGHELAHQWFGNLVTPSWWSDIWLNEGFASYMEYLTADAVAPEWKQLDQF 463
            |..::|::|..|..|:.|||||||||||||..||:||||.||||.|||.:..:|..|| .|.|.:
Human   353 PKTSSASDKLWVTRVIAHELAHQWFGNLVTMEWWNDIWLKEGFAKYMELIAVNATYPE-LQFDDY 416

  Fly   464 VVNELQAVFQLDALSTSHKISHEVFNPQEISEIFDRISYAKGSTIIRMMAHFLTNPIFRRGLSKY 528
            .:|....|...|:|::|..||.....|.:|.|:||.:||.||:.|:.|:..||....|::|:.:|
Human   417 FLNVCFEVITKDSLNSSRPISKPAETPTQIQEMFDEVSYNKGACILNMLKDFLGEEKFQKGIIQY 481

  Fly   529 LQEMAYNSATQDDLWHFLTVEAKSS-------------------GLLDDSRSVKEIMDTWTLQTG 574
            |::.:|.:|..||||..|:.....|                   ..|.::..|||:|.|||||.|
Human   482 LKKFSYRNAKNDDLWSSLSNSCLESDFTSGGVCHSDPKMTSNMLAFLGENAEVKEMMTTWTLQKG 546

  Fly   575 YPVVKVSRHPNSDVIRLEQVRFVYTNTTRED-------ESLLWYIPITFTTDSELNFANTRPTTW 632
            .|::.|.:...|  :||:|.||: ....:||       |..||:||:|::|.|. |..:..  ..
Human   547 IPLLVVKQDGCS--LRLQQERFL-QGVFQEDPEWRALQERYLWHIPLTYSTSSS-NVIHRH--IL 605

  Fly   633 MPRTKLYELENRELSLAKWFIFNVQQTGYYRVNYDLENWMAITEHLMDVDNFEDIAPANRAQLID 697
            ..:|...:|..:    ..|..|||...|||.|:|:...|..:...|.  .|...:.|.:|..||.
Human   606 KSKTDTLDLPEK----TSWVKFNVDSNGYYIVHYEGHGWDQLITQLN--QNHTLLRPKDRVGLIH 664

  Fly   698 DVMNLARGSYLSYETAMNLTRYLGHELGHVPWKAAISNFIFIDSMF-----VNSGDY-DLLKNYL 756
            ||..|.....|:.:.|:::|.||.||...   .|.:....:::|.:     .|..|. :.||.||
Human   665 DVFQLVGAGRLTLDKALDMTYYLQHETSS---PALLEGLSYLESFYHMMDRRNISDISENLKRYL 726

  Fly   757 LKQLKKVYDQVGFKDSQDESEDILVKLKRADILSMACHLGHQECIAEASRHFQNWMQTPNPDSNN 821
            |:..|.|.|    :.|..:...:..::.|:.:|.:||.|.|..||.:|:..|..||::    |..
Human   727 LQYFKPVID----RQSWSDKGSVWDRMLRSALLKLACDLNHAPCIQKAAELFSQWMES----SGK 783

  Fly   822 PIVP-NLRGVVYCSAIQYGTEYEWDFAFERFLKTNVPGEKDLLLNALGCSKEPWLLYRFLRRGIS 885
            ..:| ::..:||....|  |...|::..|::..:....|::.:|.||..||....|.:.:..|:.
Human   784 LNIPTDVLKIVYSVGAQ--TTAGWNYLLEQYELSMSSAEQNKILYALSTSKHQEKLLKLIELGME 846

  Fly   886 GQHIRKQDLFRVFAAVSTTVVGQNIAFDFLRNNWQEI--KTYMGSQMSSIHTLFKFATKGFNSKF 948
            |:.|:.|:|..:..|::....||.:|:||:|.||..:  |..:||.  .|..:....|..|:||.
Human   847 GKVIKTQNLAALLHAIARRPKGQQLAWDFVRENWTHLLKKFDLGSY--DIRMIISGTTAHFSSKD 909

  Fly   949 QLGEFENF-----VKDAHWDYDRPVQQIVEHIETSVDWMNKNYKSIVRWL 993
            :|.|.:.|     .:.:|.|.   .|.::|.|..::.|:.||..::..||
Human   910 KLQEVKLFFESLEAQGSHLDI---FQTVLETITKNIKWLEKNLPTLRTWL 956

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
superdeath	NP_651674.3	M1_APN-Q_like	121..571	CDD:341064	178/479 (37%)
		ERAP1_C	651..976	CDD:463368	95/338 (28%)
ERAP2	NP_071745.1	M1_APN-Q_like	76..543	CDD:341064	178/479 (37%)
		ERAP1_C	620..938	CDD:463368	95/337 (28%)