Protein Alignment Bicra and BICRAL

DIOPT Version :10

• Sequence 1: NP_001263051.1
• Gene: Bicra / 43435
• FlyBaseID: FBgn0039633
• Length: 3003
• Species: Drosophila melanogaster
• Sequence 2: XP_047274498.1
• Gene: BICRAL / 23506
• HGNCID: 21111
• Length: 1183
• Species: Homo sapiens
• Alignment Length: 1510
• Identity: 279/1510 - (18%)
• Similarity: 489/1510 - (32%)
• Gaps: 528/1510 - (34%)

  Fly  1135 AAPSVAPTITSDSTGFKLSSDGRQMQLVAIPQATPPSPAASSAQPPVPTPTPALTAGGATILPPQ 1199
            |||.....::...:|.:::...|              |.|.:.:||.|.|.|.        .||.
Human    43 AAPRPGAGVSERESGARVAGAAR--------------PGAPALRPPAPRPPPP--------PPPP 85

  Fly  1200 LTGMPANVSVSVGSPASAAALVPQLTGSLTLTVSEQCERLILRHDPNNPQDHQSQLILQALLKGA 1264
            |.....|                            ..::.:|.||.....|..|.|:
Human    86 LLRWRRN----------------------------PVDKALLFHDVVMDDDDDSCLL-------- 114

  Fly  1265 LPNVTIINEPTRVDPNKQTTPMLQPQQQVIQIPQPLTQPQQILQQQPKVSTAPKIEVKVANNRKL 1329
                .:|.:|             |.....:..|                           :|:..
Human   115 ----DLIGDP-------------QALNYFLHGP---------------------------SNKSS 135

  Fly  1330 SGQVTHPASSMLGMTSTTTTMSTMKPPANLPAKQNEVVSFPQ--LPLNSQVLIQQQPMISAQLQP 1392
            :..:|:...|.....|.....|...|.::|....|::...|.  |||:|.:...:..:.|:.| |
Human   136 NDDLTNAGYSAANSNSIFANSSNADPKSSLKGVSNQLGEGPSDGLPLSSSLQFLEDELESSPL-P 199

  Fly  1393 QL---QPVTVPVSLPTQPVPIPSPAPAPQL---ANNGQQRYIALPPIDPTTQQLFC-LNSVTNQI 1450
            .|   ||..: :....|...|.....|.:.   |:.|..:..|...:.|::...|. .::|:|.
Human   200 DLTEDQPFDI-LQKSLQEANITEQTLAEEAYLDASIGSSQQFAQAQLHPSSSASFTQASNVSNY- 262

  Fly  1451 TAMSAGQTAASIGPTERLLIAPAGINAQQLAQCLQLGQLHFNDVNPLPAQQQQQQVATTSSSMTL 1515
                :|||...||.|.    .|.|.:.......:|.|.:....:: :|:|........:.|.
Human   263 ----SGQTLQPIGVTH----VPVGASFASNTVGVQHGFMQHVGIS-VPSQHLSNSSQISGSG--- 315

  Fly  1516 SMPLRPQPPQQQIV-----HPIQPITNGLAITTTASSTLTTTTSTTSLTTVTKQVANVAPIIDQS 1575
                     |.|::     ||                         |:.|:..        :|.|
Human   316 ---------QIQLIGSFGNHP-------------------------SMMTINN--------LDGS 338

  Fly  1576 KAKLE-PAKAATSGAGGGAVVKKKPVRKPKATPTNASELANLKNASVVKP-------------MP 1626
            :..|: ..:.|.|...||.:|.::       ||...|...|..::.|.:|             :|
Human   339 QIILKGSGQQAPSNVSGGLLVHRQ-------TPNGNSLFGNSSSSPVAQPVTVPFNSTNFQTSLP 396

  Fly  1627 KLDPLSQK---PNNNPVQI-VQPN-VASGKQMIVVGSSSCTTTTTTTMSASIQPFQTTSGTKLVG 1686
            ..:.:.|:   ||:|.|.| :||. :..|:|           .|....:..||......|.....
Human   397 VHNIIIQRGLAPNSNKVPINIQPKPIQMGQQ-----------NTYNVNNLGIQQHHVQQGISFAS 450

  Fly  1687 VTVPM-QQQQPTGTAAILQQQQQQR--TSFSLTAT--TVATPAPMPSPTVASGVSQLQMQQLPSQ 1746
            .:.|. ....|..:..|:.||..::  ||.::::|  ::...:||..|
Human   451 ASSPQGSVVGPHMSVNIVNQQNTRKPVTSQAVSSTGGSIVIHSPMGQP----------------- 498

  Fly  1747 QAQQQLQPQQQQQLHAPKQQQPQP-------NTVSRVQTI--QL--TPQMQQIFKQVQMQIQFLT 1800
                          |||:.|...|       |:|..||||  ||  |...|.|..||..:...|.
Human   499 --------------HAPQSQFLIPTSLSVSSNSVHHVQTINGQLLQTQPSQLISGQVASEHVMLN 549

  Fly  1801 IKLQNKSTFLPVSPEIDSATIAAYNKPMTDAE---INLALQRLFAEQHRILASGKEV----PTPE 1858
               :|.|..|        .|...|..||.:.:   ::|...:.||      |||..|    .:|:
Human   550 ---RNSSNML--------RTNQPYTGPMLNNQNTAVHLVSGQTFA------ASGSPVIANHASPQ 597

  Fly  1859 ---GMLP-----------------TANGTGGFSLMPQPVQQQQQQQQQQLQSTVPEPLKTIVPAN 1903
               |.:|                 .:.|..||:.||.....           :.|.....:..|:
Human   598 LVGGQMPLQQASPTVLHLSPGQSSVSQGRPGFATMPSVTSM-----------SGPSRFPAVSSAS 651

  Fly  1904 VVQPNNHSSTPAGAATSGATTAANIQQNITQRIHIYPMQHQQQQQQQQQQQQQQPQHQQQQPQHQ 1968
            ...|:      .|:|....::.:|.
Human   652 TAHPS------LGSAVQSGSSGSNF---------------------------------------- 670

  Fly  1969 LQQTGAKPKQAQPKPPPQQEQQSQLQIKPKEPANRSKVTSQQLQQNPQPPNGTINMLPQKVSMMP 2033
               ||.:..|....|.|       :.:..:.|.:.||.||   ..:..|..||
Human   671 ---TGDQLTQPNRTPVP-------VSVSHRLPVSSSKSTS---TFSNTPGTGT------------ 710

  Fly  2034 VVQQQQQQQPQQHQQQPMLNKSGPPPLIFASSTN------MLSNSNSNNLHNSNSAMQVNNMLPL 2092
                  |||.....|:..||::.|   |.|..|.      .:....|..|...:|..:|.: ..|
Human   711 ------QQQFFCQAQKKCLNQTSP---ISAPKTTDGLRQAQIPGLLSTTLPGQDSGSKVIS-ASL 765

  Fly  2093 PPLQPQQQPQPQLQQPPTPILPPVAPTMAMGVAPGPMGNLVPSLPTIPSLPLYMPSKMDEMPTQK 2157
            ...||||:                              .:|.|.|..|::.:...|...:.|..|
Human   766 GTAQPQQE------------------------------KVVGSSPGHPAVQVESHSGGQKRPAAK 800

  Fly  2158 PKIARLSLFVRQLEVDQESCLKPDYVKPFRTKDEAVKRLIRYHCMHENDVELPSDE-----DEEF 2217
             ::.:.:..::||:.||...:.|| ...||:..:||:||:.||....:   :|::|     |.||
Human   801 -QLTKGAFILQQLQRDQAHTVTPD-KSHFRSLSDAVQRLLSYHVCQGS---MPTEEDLRKVDNEF 860

  Fly  2218 ESTALEFQDKFRQLNGKFQEILMQESTLPHRTSELLQMQQLMIDDLKGEINEIRTAEKEL----- 2277
            |:.|.:...:.:.:..|::.:|::::...:.::|::.:.::...:.:..::.    :|.|
Human   861 ETVATQLLKRTQAMLNKYRCLLLEDAMRINPSAEMVMIDRMFNQEERASLSR----DKRLALVDP 921

  Fly  2278 ------------------EQQL-KEEQTSEKSTAESDVLSEAKVKEEIK---QEPIDKSAQPDGV 2320
                              |.|. :.:|...|:::.....::|:.::..|   .||::.
Human   922 EGFQADFCCSFKLDKAAHETQFGRSDQHGSKASSSLQPPAKAQGRDRAKTGVTEPMNH------- 979

  Fly  2321 VDKFDLLKN----SADVNKA-----------FSK---SQPQQTTTVKQEESNESGEP--SVNGSV 2365
             |:|.|:.|    ||:.|.:           |.|   .|.|.|:    ||.....||  :...|.
Human   980 -DQFHLVPNHIVVSAEGNISKKTECLGRALKFDKVGLVQYQSTS----EEKASRREPLKASQCSP 1039

  Fly  2366 KSEGHDKESSKYIKKDYDNFDIESELTTSFIMKKVENKAALAKSAENRYQERNMMDQQQQQ---Q 2427
            ..|||.|.||:      .:...||:|::      :...:.|..:..|.:|::::.:..:.:   .
Human  1040 GPEGHRKTSSR------SDHGTESKLSS------ILADSHLEMTCNNSFQDKSLRNSPKNEVLHT 1092

  Fly  2428 HIKANGGDPVDQDDGWYCLQKELNLMNNDHMQQSQQQLNGNQQHLPINRQPAPQQSHFLDNSNSN 2492
            .|....|:|  |.|.......|....|...::::.:|...:         |....|..||..|.:
Human  1093 DIMKGSGEP--QPDLQLTKSLETTFKNILELKKAGRQPQSD---------PTVSGSVELDFPNFS 1146

  Fly  2493 NMMGNSNHMSDLFPN 2507
            .|....|.:....|:
Human  1147 PMASQENCLEKFIPD 1161

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Bicra	NP_001263051.1	PHA03247	<753..1222	CDD:223021	16/86 (19%)
		GLTSCR1	2173..2271	CDD:464589	22/102 (22%)
		SCP-1	<2212..2476	CDD:114219	56/318 (18%)
BICRAL	XP_047274498.1	GLTSCR1	815..915	CDD:464589	22/107 (21%)