Protein Alignment betaTub97EF and TUBA3C

DIOPT Version :10

• Sequence 1: NP_651606.2
• Gene: betaTub97EF / 43359
• FlyBaseID: FBgn0003890
• Length: 457
• Species: Drosophila melanogaster
• Sequence 2: NP_005992.1
• Gene: TUBA3C / 7278
• HGNCID: 12408
• Length: 450
• Species: Homo sapiens
• Alignment Length: 453
• Identity: 177/453 - (39%)
• Similarity: 273/453 - (60%)
• Gaps: 14/453 - (3%)

  Fly     1 MREIVHLQAGQCGNQIGSKFWEIISDEHGIDPNGYYHGESAL--QHERIDVYYNEASSGKYVPRA 63
            |||.:.:..||.|.|||:..||:...||||.|:|....:..:  ..:..:.:::|..:||:||||
Human     1 MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRA 65

  Fly    64 VLIDLEPGTMDSVRQSPVGQLFRPDNFVYGQSGAGNNWAKGHYTEGAELIDSVLEVLRKESEGCD 128
            |.:||||..:|.||.....|||.|:..:.|:..|.||:|:||||.|.|::|.||:.:||.::.|.
Human    66 VFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIVDLVLDRIRKLADLCT 130

  Fly   129 CLQGFQLAHSLGGGTGSGLGTLLISKIREEYPDRIMNSFSVVPSPKVSEVVVEPYNATLSLHQLI 193
            .||||.:.||.|||||||..:||:.::..:|..:....|::.|:|:||..||||||:.|:.|..:
Human   131 GLQGFLIFHSFGGGTGSGFASLLMERLSVDYGKKSKLEFAIYPAPQVSTAVVEPYNSILTTHTTL 195

  Fly   194 VDTDETFCIDNEALYDICYQSLRICSPTYQDLNHLVSVTMSGVTTCLRFPGQLNADLRKLAVNMV 258
            ..:|..|.:||||:||||.::|.|..|||.:||.|:...:|.:|..|||.|.||.||.:...|:|
Human   196 EHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLV 260

  Fly   259 PFPRLHFFMPGFAPLTAKGSQQYRALTVAELTQQMFDAKNMMTACDPRHGRYLTVACIFRGPMSM 323
            |:||:||.:..:||:.:.....:..|:|||:|...|:..|.|..||||||:|:....::||.:..
Human   261 PYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCMLYRGDVVP 325

  Fly   324 KEVDTQMYNVQSKNSSYFVEWIPNNVKVAVCDIPP--------RGLKMSATFIGNSTAIQEIFKR 380
            |:|:..:..:::|.:..||:|.|...||.:...||        ..::.:...:.|:|||.|.:.|
Human   326 KDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWAR 390

  Fly   381 ISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLISEYQQYQEATADDEVEFDDEQAEQ 443
            :..:|..|:.::||:|||.||||:|.||:||..::..|..:|    |....|.||.:.|:.|:
Human   391 LDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDY----EEVGVDSVEAEAEEGEE 449

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
betaTub97EF	NP_651606.2	PLN00220	1..444	CDD:215107	177/453 (39%)
TUBA3C	NP_005992.1	PTZ00335	1..440	CDD:185562	173/442 (39%)
		MREC motif. /evidence=ECO:0000250|UniProtKB:P68363	1..4		2/2 (100%)