Protein Alignment betaTub97EF and TUBA1B

DIOPT Version :10

• Sequence 1: NP_651606.2
• Gene: betaTub97EF / 43359
• FlyBaseID: FBgn0003890
• Length: 457
• Species: Drosophila melanogaster
• Sequence 2: NP_006073.2
• Gene: TUBA1B / 10376
• HGNCID: 18809
• Length: 451
• Species: Homo sapiens
• Alignment Length: 457
• Identity: 184/457 - (40%)
• Similarity: 275/457 - (60%)
• Gaps: 17/457 - (3%)

  Fly     1 MREIVHLQAGQCGNQIGSKFWEIISDEHGIDPNGYYHGESAL--QHERIDVYYNEASSGKYVPRA 63
            |||.:.:..||.|.|||:..||:...||||.|:|....:..:  ..:..:.:::|..:||:||||
Human     1 MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRA 65

  Fly    64 VLIDLEPGTMDSVRQSPVGQLFRPDNFVYGQSGAGNNWAKGHYTEGAELIDSVLEVLRKESEGCD 128
            |.:||||..:|.||.....|||.|:..:.|:..|.||:|:||||.|.|:||.||:.:||.::.|.
Human    66 VFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCT 130

  Fly   129 CLQGFQLAHSLGGGTGSGLGTLLISKIREEYPDRIMNSFSVVPSPKVSEVVVEPYNATLSLHQLI 193
            .||||.:.||.|||||||..:||:.::..:|..:....||:.|:|:||..||||||:.|:.|..:
Human   131 GLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTL 195

  Fly   194 VDTDETFCIDNEALYDICYQSLRICSPTYQDLNHLVSVTMSGVTTCLRFPGQLNADLRKLAVNMV 258
            ..:|..|.:||||:||||.::|.|..|||.:||.|:|..:|.:|..|||.|.||.||.:...|:|
Human   196 EHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLV 260

  Fly   259 PFPRLHFFMPGFAPLTAKGSQQYRALTVAELTQQMFDAKNMMTACDPRHGRYLTVACIFRGPMSM 323
            |:||:||.:..:||:.:.....:..|:|||:|...|:..|.|..||||||:|:....::||.:..
Human   261 PYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVP 325

  Fly   324 KEVDTQMYNVQSKNSSYFVEWIPNNVKVAVCDIPP--------RGLKMSATFIGNSTAIQEIFKR 380
            |:|:..:..:::|.|..||:|.|...||.:...||        ..::.:...:.|:|||.|.:.|
Human   326 KDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWAR 390

  Fly   381 ISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLISEYQQYQEATADDEVEFDDEQAEQEG 445
            :..:|..|:.::||:|||.||||:|.||:||..:|..|..:|    |....|.||   .:.|:||
Human   391 LDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDY----EEVGVDSVE---GEGEEEG 448

  Fly   446 YE 447
            .|
Human   449 EE 450

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
betaTub97EF	NP_651606.2	PLN00220	1..444	CDD:215107	181/452 (40%)
TUBA1B	NP_006073.2	PTZ00335	1..440	CDD:185562	178/442 (40%)
		MREC motif. /evidence=ECO:0000269|PubMed:31727855	1..4		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	432..451		9/26 (35%)