Protein Alignment CG5003 and FBXL2

DIOPT Version :10

• Sequence 1: NP_651593.1
• Gene: CG5003 / 43344
• FlyBaseID: FBgn0039554
• Length: 713
• Species: Drosophila melanogaster
• Sequence 2: XP_054201991.1
• Gene: FBXL2 / 25827
• HGNCID: 13598
• Length: 479
• Species: Homo sapiens
• Alignment Length: 619
• Identity: 120/619 - (19%)
• Similarity: 184/619 - (29%)
• Gaps: 235/619 - (37%)

  Fly    75 ELLFEIFQYLDTSSILAVMHCSPRFENLLLDHRFYHHIDLSNGPLPMGILEEILGRATEKTHTIK 139
            |||..||.:||..::......|..:..|.||...:..|||.|      ...::.||..|  :..|
Human    43 ELLLRIFSFLDIVTLCRCAQISKAWNILALDGSNWQRIDLFN------FQTDVEGRVVE--NISK 99

  Fly   140 ICGPPSSQHVAGEFRQFTQTLSSVFPRVVQLKVLELEGVSLDFEYIHITEFPATLRRLKLKDCSV 204
            .||                                                 ..||:|.|:.| :
Human   100 RCG-------------------------------------------------GFLRKLSLRGC-I 114

  Fly   205 RVGDTPKSIFYSIELHLLDLEDLSIEDNSWFEPYYIMGLSKLPSLRRLSLKGCQALCKFVPYGSM 269
            .|||:....|                            .....::..|:|.||..:.....|.
Human   115 GVGDSSLKTF----------------------------AQNCRNIEHLNLNGCTKITDSTCYS-- 149

  Fly   270 AARFGFQKLESLDLRQ-TPINNSDLQCFS-AIENLKELLLE-SPQILHSKQAVAKKNTNGNATDE 331
            .:|| ..||:.|||.. ..|.||.|:..| ...||:.|.|. ..||  :|..:           |
Human   150 LSRF-CSKLKHLDLTSCVSITNSSLKGISEGCRNLEYLNLSWCDQI--TKDGI-----------E 200

  Fly   332 AASPQPDSLKVL-------SDDEPSTSRAAMEHLR-ACK--VAFNLDNCSDRKEEKSPVPTEPPS 386
            |.......||.|       .:||      |::|:: .|.  |:.||.:||           ....
Human   201 ALVRGCRGLKALLLRGCTQLEDE------ALKHIQNYCHELVSLNLQSCS-----------RITD 248

  Fly   387 EG--------QDLQAKRIRAPSESDDEDTSSTSGSSSDKLEVLSLPRNGHSNAAPLSGGVDLPPL 443
            ||        ..|||..:...|...|...::. |.:..:|::|...|..|...|   |...|...
Human   249 EGVVQICRGCHRLQALCLSGCSNLTDASLTAL-GLNCPRLQILEAARCSHLTDA---GFTLLARN 309

  Fly   444 PHAADAANAADAPIAVDAANIEAPGQSPGLDPRPPRAYIYVPDAENANPRQQRSVVAVFAQGTEQ 508
            .|..:..:..:..:..|:..|:.....|.|.
Human   310 CHELEKMDLEECILITDSTLIQLSIHCPKLQ---------------------------------- 340

  Fly   509 RYIYVNQQFSLPMNVLM---PTRRHRTHPRPNYDQVVQHPMFWNMLEPLDRDYARRVRPRPPSCQ 570
              ..|:..||..:::|.   |:..::.....::.:.:.|                        |:
Human   341 --ALVSLSFSDIIHLLKMKEPSHHNKKLFGFSFCKSLSH------------------------CE 379

  Fly   571 TTPQYYVTDRAMYSFGRADRPVQPDVVWIRNINRSP--DNKLERLSLRNYHLITNHTLEHLVQCS 633
                 .:||..                 |.:::.|.  ..:|..|.|.|..|||:..||||..|.
Human   380 -----LITDDG-----------------ILHLSNSTCGHERLRVLELDNCLLITDVALEHLENCR 422

  Fly   634 --PNLVYIDVSGTSITLPAIRRFKISKPKCEVVA 665
              ..|...|..  .:|...|:|.:...|..:|.|
Human   423 GLERLELYDCQ--QVTRAGIKRMRAQLPHVKVHA 454

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5003	NP_651593.1	F-box	69..111	CDD:425796	11/35 (31%)
		leucine-rich repeat	610..635	CDD:275381	12/26 (46%)
FBXL2	XP_054201991.1	F-box_FBXL2-like	34..78	CDD:438887	11/34 (32%)
		leucine-rich repeat	77..104	CDD:275381	10/83 (12%)
		AMN1	<101..248	CDD:187754	50/257 (19%)
		leucine-rich repeat	105..124	CDD:275381	8/19 (42%)
		leucine-rich repeat	131..156	CDD:275381	7/27 (26%)
		leucine-rich repeat	157..182	CDD:275381	9/24 (38%)
		leucine-rich repeat	183..208	CDD:275381	8/37 (22%)
		AMN1	193..423	CDD:187754	61/345 (18%)
		leucine-rich repeat	209..234	CDD:275381	8/30 (27%)
		leucine-rich repeat	235..260	CDD:275381	7/35 (20%)
		leucine-rich repeat	261..286	CDD:275381	6/25 (24%)
		leucine-rich repeat	287..312	CDD:275381	7/27 (26%)
		leucine-rich repeat	313..338	CDD:275381	2/24 (8%)
		leucine-rich repeat	339..389	CDD:275381	11/131 (8%)
		leucine-rich repeat	399..418	CDD:275381	9/18 (50%)