DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13978 and MCD4

DIOPT Version :9

Sequence 1:	NP_651562.2	Gene:	CG13978 / 43303	FlyBaseID:	FBgn0039518	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_012756.1	Gene:	MCD4 / 853690	SGDID:	S000001648	Length:	919	Species:	Saccharomyces cerevisiae

Alignment Length:	992	Identity:	246/992 - (24%)
Similarity:	429/992 - (43%)	Gaps:	185/992 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWK-----LQALVV--HILLMGAILNTYFQHTLLPNLVPQKTMRELGLEPPADRLVVFVTDGLRA 58
            ||.     |.|:.|  |:..:.:|.:.||...|:..:.|.::..    .|||.||.:.|.|||||
Yeast     1 MWNKTRTTLLAVGVLFHLFYLWSIFDIYFISPLVHGMSPYQSTP----TPPAKRLFLIVGDGLRA 61

  Fly    59 AT--------------FLANNGSDVPDLKDIYRQQGRIGISRTCAPTMTRPGHIAIFAGFHEDPA 109
            .|              |||      |.::.:.......|||.|..||.:||||:|:.|||:||.:
Yeast    62 DTTFDKVTHPVSGKTEFLA------PFIRSLVMNNATYGISHTRMPTESRPGHVAMIAGFYEDVS 120

  Fly   110 ASLMHLCYNPGDFDTVFNRSRNMIGWAHSYIVGY--FVKLSHGGA--PLRFDSYM-----ERDLP 165
            |.......||.:||:.||:|      .|:|..|.  .:.:...||  |.:.|::|     |....
Yeast   121 AVTKGWKSNPVNFDSFFNQS------THTYSFGSPDILPMFKDGASDPNKVDTWMYDHTFEDFTQ 179

  Fly   166 EKLTCDKWAFDKVENFLRN------VD-NVREWRNYKPAVFFVYLADMDIAAHRFKPLSKKFFAK 223
            ..:..|.:.|..::....|      :| .:|:..|    |||::|...|.|.|.::|.|.:::..
Yeast   180 SSIELDAFVFRHLDQLFHNSTLNSTLDYEIRQDGN----VFFLHLLGCDTAGHSYRPYSAEYYDN 240

  Fly   224 LQYTQRGIRNTYELFERVFNDSRTAYLMTSDHGMNNEGAHGSGSPLEVETPLFMWGAGVKR---D 285
            ::|....|....:...:.|.|.:||::.|:||||:..|:||.|.|....|||..||||:.:   :
Yeast   241 VKYIDDQIPILIDKVNKFFADDKTAFIFTADHGMSAFGSHGDGHPNNTRTPLVAWGAGLNKPVHN 305

  Fly   286 EIDAEANFPEKPNIS-----QVDQTQLAPLMSSLIGLPPPKNNLALMPVGYLNVSDEYQAVALHL 345
            ......|:.|...:|     .|.|..:|.|||.|||:..|||::..:|:.|::..:..:..||:.
Yeast   306 PFPVSDNYTENWELSSIKRNDVKQADIASLMSYLIGVNYPKNSVGELPIAYIDGKESDKLAALYN 370

  Fly   346 NVLQLLSQAEILIGRHE---KAIFYKWLPKFKE-LHIGVIDQYAAQFDIL---KSEGN---LTDA 400
            |...:|.|  .|:.:.|   ...|||...||.| .|    ..|..:.:.|   .|||.   ..:|
Yeast   371 NARSILEQ--YLVKQDEVIDSQFFYKEYFKFVEKSH----SHYLEEIETLIQRISEGENYLEQEA 429

  Fly   401 MEFCKEYGKLAKKCLTYYNQYYQTPLIVANSMSYMIW-FYCLLLQLTRLSKKEKMQRRGFMTVST 464
            :...:|..::..:.|.|...|....:....:..::.| |:..::.|.....:..:..:....:|.
Yeast   430 ITLTEELMQITLEGLHYLTTYNWRFIRTIVTFGFVGWIFFSFIIFLKSFILENVIDDQKASPLSH 494

  Fly   465 LILAMIGILLIAMMELQKVPHIAAFYLILPVGMLIMAQAERPVRGYWIFHPLWNFGF----ILVP 525
            .:...|||||..::..|..|.....||:.|:              |:     |::.|    :|..
Yeast   495 AVFGSIGILLNWILFYQHSPFNFYMYLLFPL--------------YF-----WSYIFTNRSVLRS 540

  Fly   526 AV------------LIMSMTFIIRHLWVLYGI-----SVLLNNRRA-------LRKPSIKLFIWL 566
            .:            ::::::.|..:..::||.     ..|:.|..|       :|:.|:.: :|
Yeast   541 GIKEFFKGTSPWKRVLITISIISVYEGIVYGFFHRWTFTLITNILAFYPFICGVRELSVNI-LW- 603

  Fly   567 SLALIVTAILFMEQRTIKGLKTIPVKDYHVLYVSMVLAIIRPLILGHRHDPRVWTFNSLTLVVGA 631
                |:|::|.   .|......:.::|.:.::::.:|.|:......::...|:   ||.|..:.|
Yeast   604 ----IITSVLL---STFTLFDAVKIEDLNQIHLAGLLIILSAFYALYKIHSRI---NSYTRAIFA 658

  Fly   632 F--------------GVYQYKFYESVSSYVYVVTWSFLFFAF--LSIVYFAKSLPEARKRLELIT 680
            .              .|...:..:.:.....|..|...|.:.  :.|:::.|...:.:.||.:|.
Yeast   659 IQISLVAAMLAVTHRSVISLQLRQGLPRESQVAGWIIFFVSLFVMPILHYRKPNNDYKVRLLIIY 723

  Fly   681 INMITVLSLLTNSWGCLNFQIAITEFIFGLQIYEETKETKEIEDAKDEHTSLQNLK----GFYRY 741
            :.......:||.|:..| |....|.::  :|..|...:.||::..|||:. ||.|:    ||:
Yeast   724 LTFAPSFIILTISFESL-FYFLFTSYM--VQWIEIENKIKEMKTQKDENW-LQVLRVSVIGFF-- 782

  Fly   742 GYMILLYFYVSFFLAGH--WISSFLFKPTTARLFYPHFSLYIAGSLVLLKIFIP-SVIFIC--AL 801
                  ...|:||..|:  .||||..: :..||. |.|..::.|:|::||:.|| .::..|  .|
Yeast   783 ------LLQVAFFGTGNVASISSFSLE-SVCRLL-PIFDPFLMGALLMLKLIIPYGLLSTCLGIL 839

  Fly   802 YAMVPFVRKNARSILISIFMISNAMGLYQYYFIRNRGSWRKIRMFLDQILLTHAVN-FMLLLGIS 865
            ...:.|......|::||   :|:.:.|..:|.:|..|||..|.:.:....|....: |||:|.:
Yeast   840 NLKLNFKDYTISSLIIS---MSDILSLNFFYLLRTEGSWLDIGITISNYCLAILSSLFMLILEV- 900

  Fly   866 LAKIFLANTTMERPGQK 882
            |..:.|.|..::...:|
Yeast   901 LGHVLLKNVIIQDKTKK 917

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13978	NP_651562.2	GPI_EPT_1	42..328	CDD:293744	102/323 (32%)
CG13978	NP_651562.2	PigN	414..839	CDD:282796	97/478 (20%)
MCD4	NP_012756.1	GPI_EPT_1	46..353	CDD:293744	102/322 (32%)
MCD4	NP_012756.1	PigN	443..874	CDD:398585	97/478 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346535
Domainoid	1	1.000	42	1.000	Domainoid score	I3219
eggNOG	1	0.900	-	-		E1_COG1524
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1579
OMA	1	1.010	-	-		QHG55072
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46576
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12250
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2480
TreeFam	1	0.960	-	-
	10	9.760