Protein Alignment CG13978 and ENPP5

DIOPT Version :10

• Sequence 1: NP_651562.2
• Gene: CG13978 / 43303
• FlyBaseID: FBgn0039518
• Length: 898
• Species: Drosophila melanogaster
• Sequence 2: NP_067547.1
• Gene: ENPP5 / 59084
• HGNCID: 13717
• Length: 477
• Species: Homo sapiens
• Alignment Length: 607
• Identity: 118/607 - (19%)
• Similarity: 194/607 - (31%)
• Gaps: 231/607 - (38%)

  Fly     7 LVVHILLMGAILNTYFQHTLLPNLVPQKTMRELGLEPPADRLVVFVTDGLR------AAT----F 61
            |:|..:|....|:|.|                 .|:|...::::...||.|      ..|    :
Human     6 LLVSFILAALSLSTTF-----------------SLQPDQQKVLLVSFDGFRWDYLYKVPTPHFHY 53

  Fly    62 LANNGSDVPDLKDIYRQQGRIGISRTCAPTMTRPGHIAIFAG-FHE----------DP----AAS 111
            :...|..|..:.:::             .|.|.|.|..:..| |.|          ||    :.|
Human    54 IMKYGVHVKQVTNVF-------------ITKTYPNHYTLVTGLFAENHGIVANDMFDPIRNKSFS 105

  Fly   112 LMHLCYNPGDFDTVFNRSRNMIGWAHSYIVGYF----------VKLSHGGAPLRFDSYMERDLPE 166
            |.|:    ..:|:.|......| |..:...|:.          ||: |...|..:..|.|.
Human   106 LDHM----NIYDSKFWEEATPI-WITNQRAGHTSGAAMWPGTDVKI-HKRFPTHYMPYNES---- 160

  Fly   167 KLTCDKWAFDKVENFLRNVDNVREWRNYKPAV--FFVYLADMDIAAHRFKP-----------LSK 218
                        .:|...|..:.||...|..:  ..:|..|.|...|...|           :.|
Human   161 ------------VSFEDRVAKIIEWFTSKEPINLGLLYWEDPDDMGHHLGPDSPLMGPVISDIDK 213

  Fly   219 KFFAKLQYTQRG-IRNTYELFERVFNDSRTAYLMTSDHGMNNEGAHGSGSPLEVETPLFMWGAGV 282
            |....:|..::. :.||..|            ::||||||....          |..|.
Human   214 KLGYLIQMLKKAKLWNTLNL------------IITSDHGMTQCS----------EERLI------ 250

  Fly   283 KRDEIDAEANFPEKPNISQVDQTQLAPLMSSLIGLPPPKNNLALMPVGYLNVSDEYQAVA-LHLN 346
               |:|   .:.:|.:.:.:||:.:|.::        ||..         ...:.|:|:. .|.|
Human   251 ---ELD---QYLDKDHYTLIDQSPVAAIL--------PKEG---------KFDEVYEALTHAHPN 292

  Fly   347 VLQLLSQAEILIGRHEKAIFYKWLPKFKELHIGVIDQYAAQFDILKSE------GN--------- 396
             |.:..:.::....|     ||:..:.:.: |.|.|:   .:.||:::      ||
Human   293 -LTVYKKEDVPERWH-----YKYNSRIQPI-IAVADE---GWHILQNKSDDFLLGNHGYDNALAD 347

  Fly   397 -----LTDAMEFCKEYGKLAKKCLTYYNQYYQTPLIVANSMSYMIWFYCLLLQLTRLSKKEKMQR 456
                 |.....|.|.:.|.|......|      ||:            |.||.:|      .|..
Human   348 MHPIFLAHGPAFRKNFSKEAMNSTDLY------PLL------------CHLLNIT------AMPH 388

  Fly   457 RG-FMTVSTLILAMIGILLIAMMELQKVPHIAAFYLILPVGMLIMAQAERPVRG---YWIFHPLW 517
            .| |..|..|:.:       ||..:  ||:..: .::||..   :..||....|   |:|
Human   389 NGSFWNVQDLLNS-------AMPRV--VPYTQS-TILLPGS---VKPAEYDQEGSYPYFI----- 435

  Fly   518 NFGFILVPAVLIMSMTFIIRHL 539
              |..|...::|:.....|:||
Human   436 --GVSLGSIIVIVFFVIFIKHL 455

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG13978	NP_651562.2	GPI_EPT_1	42..328	CDD:293744	62/334 (19%)
		PigN	413..839	CDD:461508	29/131 (22%)
ENPP5	NP_067547.1	Enpp	28..382	CDD:293742	86/467 (18%)