DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42534 and ESPN

DIOPT Version :10

Sequence 1:NP_651560.2 Gene:CG42534 / 43298 FlyBaseID:FBgn0260487 Length:1555 Species:Drosophila melanogaster
Sequence 2:XP_011540533.1 Gene:ESPN / 83715 HGNCID:13281 Length:1341 Species:Homo sapiens


Alignment Length:1035 Identity:225/1035 - (21%)
Similarity:335/1035 - (32%) Gaps:360/1035 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   240 GEVESLRAVLAA---GASVAKP-DANGGTPLHYAAQMCGASKQDSKQQASSSNSSRLSLEILGIL 300
            ||::.||::.||   |.|:..| ||   .|:|:||:   |.|                |..|..|
Human    13 GELDVLRSLHAAGLLGPSLRDPLDA---LPVHHAAR---AGK----------------LHCLRFL 55

  Fly   301 LSHPQSSVDVQDKDGRQPLLWAASAGSAKAVIALV-KAGARVESSDKDGLTALHCAGSRGHTECI 364
            :.........:.::|..|...|::.|....:..|: :.|.||:..|..|.|.||.|...||.|.:
Human    56 VEEAALPAAARARNGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVV 120

  Fly   365 DTLI---GLCGAPTDLIDSNGCTALHYAVTLGHADATARLLDLEADP---NRQDRKGRTPAHCGC 423
            :.|:   |  |.||...|. |...:|||...|  |..:..|.:|..|   |.|.:.|.||.:..|
Human   121 NWLLHHGG--GDPTAATDM-GALPIHYAAAKG--DFPSLRLLVEHYPEGVNAQTKNGATPLYLAC 180

  Fly   424 SKGQFE-TLKLLKERGANLWLRNAKGDLPLHEAAASGRRELLEWLLAQRPKQVNTTSNDGRSLLH 487
            .:|..| |..|::|.||:...|...|..|||.||..|...::.||::.....::....||.:.:|
Human   181 QEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMH 245

  Fly   488 IAAANDYTDMCKLLLDYGADVNAVYRNSRGLVLTPLDGALQRGHRSTAKFLQANGGQPANKVRLS 552
            .||:..:|.:...||.:|.:::|.....     |||..|.:.|.....:.|..||.         
Human   246 FAASRGHTKVLSWLLLHGGEISADLWGG-----TPLHDAAENGELECCQILVVNGA--------- 296

  Fly   553 SRRTGNPFHETNATDMVRPLKYVEKEELHDLRSSKKYVVYLKRSDSDNGNENGKADVGDGDCSCS 617
                                      || |:|....|..      :|..:.||            
Human   297 --------------------------EL-DVRDRDGYTA------ADLSDFNG------------ 316

  Fly   618 EQTYRKEQRLRHVCRRHKRRQLRRRTSSCGESKHERCSEICRSKSNIEIRRR-KSRERYASSSEW 681
                                             |..|:...|:..|:.:..| .||:   .|:|.
Human   317 ---------------------------------HSHCTRYLRTVENLSVEHRVLSRD---PSAEL 345

  Fly   682 EEESAEDSCENCCYHKRQKDRVVNRKRSTSSRKSKNRDSSDPDE--KNH---SENHSSPEKGSRK 741
            |              .:|.|..::...:|.|.:..|.|.|.|..  .|:   |.:||| .||...
Human   346 E--------------AKQPDSGMSSPNTTVSVQPLNFDLSSPTSTLSNYDSCSSSHSS-IKGQHP 395

  Fly   742 PLAVNGDHQAD---------------NGKDQTSTKERPPSASRHQTPPTKEGTFIKSPTQSAKSE 791
            |..::....||               .|.....|...||.:  ...||...||.:..|.....:.
Human   396 PCGLSSARAADIQSYMDMLNPELGLPRGTIGKPTPPPPPPS--FPPPPPPPGTQLPPPPPGYPAP 458

  Fly   792 K---SGQMDNLLVEESHAVELTDEEQEAAKSVVTQVDVHHDAEEIQTSKSSEEAPQAEENGKEKE 853
            |   ..|..::.::..:  :|...|.||.|..::..|.|                    :|..::
Human   459 KPPVGPQAADIYMQTKN--KLRHVETEALKKELSSCDGH--------------------DGLRRQ 501

  Fly   854 SEQEVKLQLSEEETQLVSKEVEQVIIIAATALSSESKSSSEEKSVEKELPKEGQAPGEN------ 912
            ..                              |.:.::.|::.|......:.|:.|||.      
Human   502 DS------------------------------SRKPRAFSKQPSTGDYYRQLGRCPGETLAARPG 536

  Fly   913 --HDEEVK----EH------QNPPTPYAPPAQPSTPPPPPKEEAAKPPSAAEQPQPNANTVEGME 965
              |.||..    .|      .:|......|..|..||||..|.|:.||.|...|..:|....|..
Human   537 MAHSEEAALLPGNHVPNGCAADPKASRELPPPPPPPPPPLPEAASSPPPAPPLPLESAGPGCGQR 601

  Fly   966 SAAAEPASV-----GKKTEQME-----------LAEAKPKPNTNPTP-----------IPPPTAA 1003
            .:::....|     .|.|:...           |||.|...:..|||           |..|...
Human   602 RSSSSTGKVRVLRHRKSTKSFNMMSPTGDNSELLAEIKAGKSLKPTPQSKGLTTVFSGIGQPAFQ 666

  Fly  1004 PPGP-PS-------AESKKPPAAP-QPR------PSTPQTPTP------------------PQPE 1035
            |..| ||       ..|..||||. ||.      |..|.||.|                  |.||
Human   667 PDSPLPSVSPALSPVRSPTPPAAGFQPLLNGSLVPVPPTTPAPGVQLDVEALIPTHDEQGRPIPE 731

  Fly  1036 ------------PPQREQETRRSFTLLPS---------DSADDDPVLNPNSNPPASASDEPAGER 1079
                        ..|.|:|.||..|...|         .|.:.:.:|.            |.||.
Human   732 WKRQVMVRKMQLKMQEEEEQRRKLTAASSCCYPREGWRYSREHNAILG------------PFGEL 784

  Fly  1080 KSSFHVLKSDDSLDESTKRPGRKVDYEAGNQVFQVVGEGASAVQLPSAAELEKMDYEYEE 1139
            .:...:|:.:..::.                 .||:.:....     .|.||:::.|.|:
Human   785 MTEADILRIEQQIEN-----------------LQVLHKAQKL-----EARLEQLELELEQ 822

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42534NP_651560.2 Ank_2 127..226 CDD:463710
ANK repeat 195..226 CDD:293786
ANKYR 209..514 CDD:440430 85/285 (30%)
ANK repeat 228..259 CDD:293786 9/22 (41%)
ANK repeat 314..345 CDD:293786 8/31 (26%)
ANK repeat 347..379 CDD:293786 13/34 (38%)
ANK repeat 381..412 CDD:293786 10/33 (30%)
ANK repeat 414..479 CDD:293786 21/65 (32%)
ANK repeat 419..445 CDD:293786 8/26 (31%)
ANK repeat 481..511 CDD:293786 9/29 (31%)
Ank_2 486..572 CDD:463710 16/85 (19%)
ANK repeat 516..542 CDD:293786 6/25 (24%)
ESPNXP_011540533.1 ANKYR 2..277 CDD:440430 87/295 (29%)
ANK repeat 39..67 CDD:293786 9/46 (20%)
ANK repeat 69..101 CDD:293786 8/31 (26%)
ANK repeat 103..135 CDD:293786 13/33 (39%)
ANK repeat 137..169 CDD:293786 10/34 (29%)
ANK repeat 171..203 CDD:293786 11/31 (35%)
PLN03192 <196..365 CDD:215625 52/277 (19%)
ANK repeat 239..269 CDD:293786 9/29 (31%)
ANK repeat 271..302 CDD:293786 11/71 (15%)
WH2 627..652 CDD:460490 7/24 (29%)
Blue background indicates that the domain is not in the aligned region.

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