DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(3)mbt and L3MBTL3

DIOPT Version :9

Sequence 1:	NP_733209.1	Gene:	l(3)mbt / 43288	FlyBaseID:	FBgn0002441	Length:	1477	Species:	Drosophila melanogaster
Sequence 2:	XP_006715639.1	Gene:	L3MBTL3 / 84456	HGNCID:	23035	Length:	815	Species:	Homo sapiens

Alignment Length:	904	Identity:	271/904 - (29%)
Similarity:	414/904 - (45%)	Gaps:	178/904 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   543 SSSSDSSSYSDVEVVPTKKTEKELSMLPG------------ISIIKAES---------------L 580
            :.|:.|:|..:.:|......:..:..|||            :.:|..|:               :
Human     2 TESASSTSGQEFDVFSVMDWKDGVGTLPGSDLKFRVNEFGALEVITDENEMENVKKATATTTWMV 66

  Fly   581 PLSRE----DFERSLRCDEQVPQTPPKSSSSSSSGSHASEMSPPPKLADPKPSSPPAKNAKKAND 641
            |.::|    |..:||          |...||:......:.|...||...|.|:|||:........
Human    67 PTAQEAYTGDLAKSL----------PLFFSSTPMVVTNTYMLMTPKSTSPAPTSPPSSRPVFPPA 121

  Fly   642 HDANPSPSSKTNDFKKSMMQNLNMLKWRGQQPANLQNSTVRFELNEFNFLQINERCQPRQGPAAY 706
            :..:| |...|...:|:.|      .:|.:.|..::.
Human   122 YWTSP-PGCPTVFSEKTGM------PFRLKDPVKVEG---------------------------- 151

  Fly   707 FERPLYDRPGRRPSACVHPLLYLCQRCNFHGPAADFLA-PHFCSVGCVR------RSQKRRLPQS 764
                                |..|:.|..:|...:.|: .::||..|.|      :.::|.:.:.
Human   152 --------------------LQFCENCCQYGNVDECLSGGNYCSQNCARHIKDKDQKEERDVEED 196

  Fly   765 TQKE----SKISRTQLEQTAGTAPDLPQK--RQTNYKPHKSLSAIQEQLQQRQKD---------- 813
            .::|    |:..:.:|...|.|..|..::  ...|.:..:.|...|...::|:.|
Human   197 NEEEDPKCSRKKKPKLSLKADTKEDGEERDDEMENKQDVRILRGSQRARRKRRGDSAVLKQGLPP 261

  Fly   814 KPRKPFRWSEYLKSKGKDVAAPIHLFL--NPFPISPNCFEIGMKLEAIDPENCSLFCVCSIVEVR 876
            |.:|.:.|:.||:.: |.||.|..||.  ..||.:.|.|::|||||.:|||:.|::||.::.||.
Human   262 KGKKAWCWASYLEEE-KAVAVPAKLFKEHQSFPYNKNGFKVGMKLEGVDPEHQSVYCVLTVAEVC 325

  Fly   877 GYRLKLSFDGYSSMYDFWVNADSQDIFPPGWCDETARVLQAPKDYNSERFSWSRYLVKTGGKAAP 941
            |||:||.|||||..||||||||:.||.|.|||::|...|..||.|..|.|:|..||.....:|||
Human   326 GYRIKLHFDGYSDCYDFWVNADALDIHPVGWCEKTGHKLHPPKGYKEEEFNWQTYLKTCKAQAAP 390

  Fly   942 RALFGHLNMQQQMDVRNGFAVGMHLEAEDLNDTGKICVATVTDILDERIRVHFDGWDDCYDLWVH 1006
            ::||.:.|:..   :.:||.|||.|||.|..:...||||||||::|.|..||||.||:.||.|..
Human   391 KSLFENQNITV---IPSGFRVGMKLEAVDKKNPSFICVATVTDMVDNRFLVHFDNWDESYDYWCE 452

  Fly  1007 ITSPYIHPCGW-HEGRQQLIVPPDYQK-SAFIWDDYISEVGGMAASKELFTPRQPMEYQERMKLE 1069
            .:||:|||.|| .|.|:.||.||.|.. ..|.||.|:.|...:.|....|..:.|..:|::||||
Human   453 ASSPHIHPVGWCKEHRRTLITPPGYPNVKHFSWDKYLEETNSLPAPARAFKVKPPHGFQKKMKLE 517

  Fly  1070 VVDQRNPCLIRPATVVTRKGYRVQLHLDCWPTEYYFWLEDDSPDLHPIGWCEATSHELETPPGYL 1134
            |||:|||..||.|||.....:||::|.|.|...|.:|::.||||:||:|||..|.|.|:.|   |
Human   518 VVDKRNPMFIRVATVADTDDHRVKVHFDGWNNCYDYWIDADSPDIHPVGWCSKTGHPLQPP---L 579

  Fly  1135 QPKSVMP------CDVEGCRGFGNAKRF-NLNVHALRECCPYAPENWRQWRSKTVKPPRVA---- 1188
            .|..:|.      |...||:|.|:.||. :|..|:... |||:..|..:.|   :.|.|::
Human   580 SPLELMEASEHGGCSTPGCKGIGHFKRARHLGPHSAAN-CPYSEINLNKDR---IFPDRLSGEMP 640

  Fly  1189 ------PENIRRGWAKKTKRACSEAKQAIKEDSQQEIVYPKVAEVVQAKRKTSPCEEKVVKKQKQ 1247
                  |.|      |:|....|.:...|: |...:.|.....|..:::.:||        .:.:
Human   641 PASPSFPRN------KRTDANESSSSPEIR-DQHADDVKEDFEERTESEMRTS--------HEAR 690

  Fly  1248 MQKEEDAEQVPDERSLAIARSFVKDYGPQFLPNYRL-WQLNSAFKLDDVRTNPL----HWTSWDV 1307
            ..:||...|....|| |:..||...     :|...| |:..|.. |..|...|.    .|::.:|
Human   691 GAREEPTVQQAQRRS-AVFLSFKSP-----IPCLPLRWEQQSKL-LPTVAGIPASKVSKWSTDEV 748

  Fly  1308 CEYIERALDSTDIAKVIFEQDIDGRALLMLGRKELDTYLKLKVGPAVKLYSLILNLRIA 1366
            .|:|:......:..||..::.|||.|.|::.:.::...:.:|:|||:|:::.||..:.|
Human   749 SEFIQSLPGCEEHGKVFKDEQIDGEAFLLMTQTDIVKIMSIKLGPALKIFNSILMFKAA 807

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)mbt	NP_733209.1	MBT	822..918	CDD:214723	51/97 (53%)
		MBT	929..1028	CDD:214723	47/99 (47%)
		MBT	1038..1130	CDD:214723	41/91 (45%)
		SAM_PNT	1279..1366	CDD:280377	25/91 (27%)
L3MBTL3	XP_006715639.1	MBT	271..367	CDD:214723	51/96 (53%)
		MBT	380..474	CDD:214723	47/96 (49%)
		MBT	486..578	CDD:214723	41/91 (45%)
		zf-C2HC	592..619	CDD:279824	9/27 (33%)
		SAM	740..806	CDD:197735	18/65 (28%)
		SAM_Scm-like-3MBT3,4	740..805	CDD:188981	18/64 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149806
Domainoid	1	1.000	97	1.000	Domainoid score	I7260
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H18226
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002225
OrthoInspector	1	1.000	-	-		otm41370
orthoMCL	1	0.900	-	-		OOG6_104389
Panther	1	1.100	-	-	O	PTHR12247
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5341
SonicParanoid	1	1.000	-	-		X1471
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.870