Protein Alignment l(3)mbt and L3MBTL3

DIOPT Version :10

• Sequence 1: NP_733209.1
• Gene: l(3)mbt / 43288
• FlyBaseID: FBgn0002441
• Length: 1477
• Species: Drosophila melanogaster
• Sequence 2: XP_006715639.1
• Gene: L3MBTL3 / 84456
• HGNCID: 23035
• Length: 815
• Species: Homo sapiens
• Alignment Length: 904
• Identity: 271/904 - (29%)
• Similarity: 414/904 - (45%)
• Gaps: 178/904 - (19%)

  Fly   543 SSSSDSSSYSDVEVVPTKKTEKELSMLPG------------ISIIKAES---------------L 580
            :.|:.|:|..:.:|......:..:..|||            :.:|..|:               :
Human     2 TESASSTSGQEFDVFSVMDWKDGVGTLPGSDLKFRVNEFGALEVITDENEMENVKKATATTTWMV 66

  Fly   581 PLSRE----DFERSLRCDEQVPQTPPKSSSSSSSGSHASEMSPPPKLADPKPSSPPAKNAKKAND 641
            |.::|    |..:||          |...||:......:.|...||...|.|:|||:........
Human    67 PTAQEAYTGDLAKSL----------PLFFSSTPMVVTNTYMLMTPKSTSPAPTSPPSSRPVFPPA 121

  Fly   642 HDANPSPSSKTNDFKKSMMQNLNMLKWRGQQPANLQNSTVRFELNEFNFLQINERCQPRQGPAAY 706
            :..:| |...|...:|:.|      .:|.:.|..::.
Human   122 YWTSP-PGCPTVFSEKTGM------PFRLKDPVKVEG---------------------------- 151

  Fly   707 FERPLYDRPGRRPSACVHPLLYLCQRCNFHGPAADFLA-PHFCSVGCVR------RSQKRRLPQS 764
                                |..|:.|..:|...:.|: .::||..|.|      :.::|.:.:.
Human   152 --------------------LQFCENCCQYGNVDECLSGGNYCSQNCARHIKDKDQKEERDVEED 196

  Fly   765 TQKE----SKISRTQLEQTAGTAPDLPQK--RQTNYKPHKSLSAIQEQLQQRQKD---------- 813
            .::|    |:..:.:|...|.|..|..::  ...|.:..:.|...|...::|:.|
Human   197 NEEEDPKCSRKKKPKLSLKADTKEDGEERDDEMENKQDVRILRGSQRARRKRRGDSAVLKQGLPP 261

  Fly   814 KPRKPFRWSEYLKSKGKDVAAPIHLFL--NPFPISPNCFEIGMKLEAIDPENCSLFCVCSIVEVR 876
            |.:|.:.|:.||:.: |.||.|..||.  ..||.:.|.|::|||||.:|||:.|::||.::.||.
Human   262 KGKKAWCWASYLEEE-KAVAVPAKLFKEHQSFPYNKNGFKVGMKLEGVDPEHQSVYCVLTVAEVC 325

  Fly   877 GYRLKLSFDGYSSMYDFWVNADSQDIFPPGWCDETARVLQAPKDYNSERFSWSRYLVKTGGKAAP 941
            |||:||.|||||..||||||||:.||.|.|||::|...|..||.|..|.|:|..||.....:|||
Human   326 GYRIKLHFDGYSDCYDFWVNADALDIHPVGWCEKTGHKLHPPKGYKEEEFNWQTYLKTCKAQAAP 390

  Fly   942 RALFGHLNMQQQMDVRNGFAVGMHLEAEDLNDTGKICVATVTDILDERIRVHFDGWDDCYDLWVH 1006
            ::||.:.|:..   :.:||.|||.|||.|..:...||||||||::|.|..||||.||:.||.|..
Human   391 KSLFENQNITV---IPSGFRVGMKLEAVDKKNPSFICVATVTDMVDNRFLVHFDNWDESYDYWCE 452

  Fly  1007 ITSPYIHPCGW-HEGRQQLIVPPDYQK-SAFIWDDYISEVGGMAASKELFTPRQPMEYQERMKLE 1069
            .:||:|||.|| .|.|:.||.||.|.. ..|.||.|:.|...:.|....|..:.|..:|::||||
Human   453 ASSPHIHPVGWCKEHRRTLITPPGYPNVKHFSWDKYLEETNSLPAPARAFKVKPPHGFQKKMKLE 517

  Fly  1070 VVDQRNPCLIRPATVVTRKGYRVQLHLDCWPTEYYFWLEDDSPDLHPIGWCEATSHELETPPGYL 1134
            |||:|||..||.|||.....:||::|.|.|...|.:|::.||||:||:|||..|.|.|:.|   |
Human   518 VVDKRNPMFIRVATVADTDDHRVKVHFDGWNNCYDYWIDADSPDIHPVGWCSKTGHPLQPP---L 579

  Fly  1135 QPKSVMP------CDVEGCRGFGNAKRF-NLNVHALRECCPYAPENWRQWRSKTVKPPRVA---- 1188
            .|..:|.      |...||:|.|:.||. :|..|:... |||:..|..:.|   :.|.|::
Human   580 SPLELMEASEHGGCSTPGCKGIGHFKRARHLGPHSAAN-CPYSEINLNKDR---IFPDRLSGEMP 640

  Fly  1189 ------PENIRRGWAKKTKRACSEAKQAIKEDSQQEIVYPKVAEVVQAKRKTSPCEEKVVKKQKQ 1247
                  |.|      |:|....|.:...|: |...:.|.....|..:::.:||        .:.:
Human   641 PASPSFPRN------KRTDANESSSSPEIR-DQHADDVKEDFEERTESEMRTS--------HEAR 690

  Fly  1248 MQKEEDAEQVPDERSLAIARSFVKDYGPQFLPNYRL-WQLNSAFKLDDVRTNPL----HWTSWDV 1307
            ..:||...|....|| |:..||...     :|...| |:..|.. |..|...|.    .|::.:|
Human   691 GAREEPTVQQAQRRS-AVFLSFKSP-----IPCLPLRWEQQSKL-LPTVAGIPASKVSKWSTDEV 748

  Fly  1308 CEYIERALDSTDIAKVIFEQDIDGRALLMLGRKELDTYLKLKVGPAVKLYSLILNLRIA 1366
            .|:|:......:..||..::.|||.|.|::.:.::...:.:|:|||:|:::.||..:.|
Human   749 SEFIQSLPGCEEHGKVFKDEQIDGEAFLLMTQTDIVKIMSIKLGPALKIFNSILMFKAA 807

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(3)mbt	NP_733209.1	PRK10819	<332..>427	CDD:236768
		MBT_L3MBTL1-like_rpt1	846..945	CDD:439091	52/98 (53%)
		MBT_L3MBTL1-like_rpt2	957..1045	CDD:439092	47/89 (53%)
		MBT_L3MBTL1-like_rpt3	1058..1130	CDD:439093	36/71 (51%)
		SAM_PNT	1278..1367	CDD:460486	26/94 (28%)
L3MBTL3	XP_006715639.1	MBT_L3MBTL3_rpt1	294..394	CDD:439122	52/99 (53%)
		MBT_L3MBTL3_rpt2	401..493	CDD:439125	47/94 (50%)
		MBT_L3MBTL3_rpt3	502..579	CDD:439128	38/79 (48%)
		SAM_Scm-like-3MBT3,4	740..805	CDD:188981	18/64 (28%)