DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(3)mbt and mbtd1

DIOPT Version :9

Sequence 1:	NP_733209.1	Gene:	l(3)mbt / 43288	FlyBaseID:	FBgn0002441	Length:	1477	Species:	Drosophila melanogaster
Sequence 2:	XP_005169539.2	Gene:	mbtd1 / 568340	ZFINID:	ZDB-GENE-060810-138	Length:	705	Species:	Danio rerio

Alignment Length:	763	Identity:	178/763 - (23%)
Similarity:	280/763 - (36%)	Gaps:	235/763 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   617 MSPPPKLADPKPSSPPAKNAKKAND------------HDANPSPSSK-TNDFKKSMMQNLNMLKW 668
            |..|..:|:..|     ::.:|..|            .|::.|.||: |.|...|:..:|.::|.
Zfish     1 MENPRDMAEHTP-----RSERKRRDSFGMFDGYDSCSEDSSSSSSSEDTEDEVPSIPASLPIIKN 60

  Fly   669 RGQQPANLQNSTVRFELNEFNFLQINERCQPRQGPAAYFERPLYDRPGRRPSACVHPLLYLCQRC 733
            .||                                       :|..|..:..      :..|:.|
Zfish    61 NGQ---------------------------------------VYTYPDGKAG------MATCEMC 80

  Fly   734 NFHGPAADFLA--PHFCSVGCVRRSQKRRLPQSTQKESKISRTQLEQTAGTAPDLPQKRQTNYKP 796
            ...|....|.:  ..||||.|     .|....:::|.|.::|.|      ..|...:.:....:|
Zfish    81 GMVGVRDAFYSKTKRFCSVSC-----SRSYSSNSKKASILARLQ------GKPPTKKAKVLQKQP 134

  Fly   797 HKSLSAIQEQLQQRQKDK-------PRKPFRWSEYLKSKGKDVAAPIHLFLN-PFPISPNCFEIG 853
            ..:..|...|.|..|:::       |.:.|.|.:|:.|... |.||:..|.: |..:.......|
Zfish   135 LMAKLAAYAQYQASQQNQAKSKSVVPVEGFDWGQYICSNNL-VGAPVSCFKHVPMGMCWGDIAEG 198

  Fly   854 MKLEAIDPE---NCSLFCVCSIVEVRGYRLKLSFDGY--SSMYDFWVNADSQDIFPPGWCDETAR 913
            :::|..:.:   :..::.|..||::.|::..|.::|:  .|..|||.|....:|.|.|||..:.:
Zfish   199 LRVEVFNSDTNLSTKVYWVAEIVKLAGFKALLRYEGFDNDSSRDFWCNLCIPEIHPVGWCASSGK 263

  Fly   914 VLQAPKDYNSERFSWSRYLVK--TGGKAAP----------------------------------- 941
            .|..||....:..:|..:|||  ||.|..|
Zfish   264 PLVPPKSIQHKYSNWKAFLVKRLTGAKTLPPEFATKVQENMQYPFKKLMRVEVVDKTHLCRTRVA 328

  Fly   942 ---RALFGHLNM-------------------------------------------QQQMDV---- 956
               :.:.|.|.:                                           :.|||.
Zfish   329 LVEQVIGGRLRLVYEESQDGTDDFWCHMLSPLIHSIGWSRSIGHRFKRSEVSKKIEGQMDAPSQL 393

  Fly   957 --------RNG--FAVGMHLEAEDLNDTGKICVATVTDIL-DERIRVHFDG--------WDDCYD 1002
                    :||  |..||.|||.|..:...||||||..:| |..:.:..||        | .||
Zfish   394 FLKIKDVDQNGDWFKDGMKLEAIDPLNLSAICVATVRKVLADGYLMIGIDGSEAADGSDW-FCY- 456

  Fly  1003 LWVHITSPYIHPCGWHEGRQQLIVPP-DYQKSAFIWDDYISEVGGMAASKELFTPRQPME-YQER 1065
               |.|||.|.|.|:.|.....:.|| ...|..|.|.||:.|:|.:||..:||....|.. ::..
Zfish   457 ---HSTSPSIFPVGFCEINSIELTPPRGCTKLPFKWFDYLREIGSIAAPVKLFNKDVPNHGFRVG 518

  Fly  1066 MKLEVVDQRNPCLIRPATVVTRKGYR-VQLHLDCWPTEYYFWLEDDSPDLHPIGWCEATSHELET 1129
            ||||.||...|.|:..|| |||..:| :::|.|.|..||..|::.:||||:|||||:.|.::|:.
Zfish   519 MKLEAVDLMEPRLVCVAT-VTRIVHRLLRIHFDGWEDEYDQWVDCESPDLYPIGWCQLTGYQLQP 582

  Fly  1130 PPGYL---QPKSVMPCDVEGCRGFGNAKRFNLNV--------HALRECC-----PYAPENWRQWR 1178
            |....   .|.:|.....:..:..|..|:..:.|        ..||...     ...|.::....
Zfish   583 PAAQTTREAPPNVSKQKKKAAQYKGQKKKRKIPVGRRPIGLGGPLRRRSFSGDEEQTPPHYLSHF 647

  Fly  1179 SKTVKPPRVAPENIRRGWAKKTKRACSEAKQAIKEDSQQEIVYPKVAE 1226
            |.:.:||....|        :.:...|||...:||::      |::.|
Zfish   648 SGSRRPPASGVE--------RDRSLNSEASLQVKEET------PEIDE 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)mbt	NP_733209.1	MBT	822..918	CDD:214723	26/101 (26%)
		MBT	929..1028	CDD:214723	42/204 (21%)
		MBT	1038..1130	CDD:214723	40/93 (43%)
		SAM_PNT	1279..1366	CDD:280377
mbtd1	XP_005169539.2	MBT	169..268	CDD:214723	26/99 (26%)
		MBT	285..375	CDD:214723	6/89 (7%)
		MBT	384..479	CDD:214723	33/99 (33%)
		MBT	491..583	CDD:214723	40/92 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000