Protein Alignment l(3)mbt and Phc2

DIOPT Version :10

• Sequence 1: NP_733209.1
• Gene: l(3)mbt / 43288
• FlyBaseID: FBgn0002441
• Length: 1477
• Species: Drosophila melanogaster
• Sequence 2: NP_061244.1
• Gene: Phc2 / 54383
• MGIID: 1860454
• Length: 850
• Species: Mus musculus
• Alignment Length: 274
• Identity: 55/274 - (20%)
• Similarity: 87/274 - (31%)
• Gaps: 96/274 - (35%)

  Fly   306 RGTTLILAGTLFNM-VAMGALMRDPEWMIEESRL-----------------ESRAQSIQTFSNSS 352
            |....||..||..| |.|...:.:|| .:::.||                 |.|||
Mouse   127 RECACILFRTLSRMDVGMYGALPEPE-TVDQLRLLFTMGSLHPAFSFYQREELRAQ--------- 181

  Fly   353 VYLDEIKKLIETGIP------KEHVLD-TLVTNVNTEANQAIPPEDPAMTKKYSSEVALPTFFSE 410
              ||.:::..:...|      :|...| ||.:|.|...:.....|...:.|....|:::
Mouse   182 --LDRLQRWSQFSRPGFLCPHREDDGDWTLCSNANPHLSSTSQREVVHIEKIILKEISV------ 238

  Fly   411 QEQHGAGGGGPRAGGGNLHASHRSLRHNVLTKETFKRSGRLAQAK-ARLASTETLNSYEKLSD-- 472
                         ||...|.|.                    :.| :..:|:....|:.:|.|
Mouse   239 -------------GGDGRHYSF--------------------EVKWSDSSSSAVTKSHRELEDFL 270

  Fly   473 -EEEHEHHPDGVSLGIHASLKTLSVASLEDGYLSEKRAQELHVKAGGSTWSLDEVA--------L 528
             :...|..|.|...||        |..|..|...|.|..|.:::....:.|.|.:.        |
Mouse   271 LKLPKEQSPGGFEKGI--------VKLLSRGDQCESRDLERNLREKFLSLSQDVLRRCDISRFFL 327

  Fly   529 AGSLVVPSPHGDAA 542
            :.:.|:|..|..:|
Mouse   328 SDASVLPCSHCTSA 341

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(3)mbt	NP_733209.1	PRK10819	<332..>427	CDD:236768	20/118 (17%)
		MBT_L3MBTL1-like_rpt1	846..945	CDD:439091
		MBT_L3MBTL1-like_rpt2	957..1045	CDD:439092
		MBT_L3MBTL1-like_rpt3	1058..1130	CDD:439093
		SAM_PNT	1278..1367	CDD:460486
Phc2	NP_061244.1	Disordered. /evidence=ECO:0000269|PubMed:27827373	1..79
		Interaction with BMI1. /evidence=ECO:0000269|PubMed:27827373	33..56
		PHA03247	<216..540	CDD:223021	30/173 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	233..314		21/127 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	335..386		2/7 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	402..436
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	528..553
		HD1	550..579
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	597..624
		PHC2_SAM_assoc	662..781	CDD:465202
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	676..712
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	725..764
		SAM_Ph1,2,3	781..849	CDD:188976