DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(3)mbt and phc1

DIOPT Version :9

Sequence 1:	NP_733209.1	Gene:	l(3)mbt / 43288	FlyBaseID:	FBgn0002441	Length:	1477	Species:	Drosophila melanogaster
Sequence 2:	XP_005158395.1	Gene:	phc1 / 403008	ZFINID:	ZDB-GENE-081022-39	Length:	901	Species:	Danio rerio

Alignment Length:	809	Identity:	155/809 - (19%)
Similarity:	257/809 - (31%)	Gaps:	288/809 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PLSMASAEAKQLQRNISLSMSPANGGV-----ISPSTANCNGVASAS---GGNPNPNSLLTL--- 56
            |.:.||......|..::||.:.|.|.:     |.|:|:..:...|.|   |||......:.|
Zfish    91 PNNSASQPTSSAQCTVNLSTTSAGGTMTNPRPIGPATSAASTALSQSVLLGGNSGGQGQMYLRVN 155

  Fly    57 ----APRKEELRFLPLAPMGGNKTCNI-TISNVQPMK------SKLKSVNIVPNSIKSAG----- 105
                ||...:|.|:|    ||..|..: |::..||.:      .:.:.....|.|..|..
Zfish   156 RSLRAPLTPQLIFMP----GGTATATVATVAQTQPQQQPQQQPQQQQQQEATPTSSSSQSDNDQV 216

  Fly   106 -----------AGATVGSADA---------PLFQLVPSP-------------------------- 124
                       ..|||.:..|         ||.|...:|
Zfish   217 QNLAMRCVSTPRAATVKTEFADRKETTGTFPLNQQTQTPQQFGQSTQQVQPQTQPLANAKLQSFS 281

  Fly   125 --SNPSQPLVAILAPNRKTTL-LGGGASNGQP-----------VVIRSGTPLHK----------- 164
              :|||.|.:.:...|:.... ...|||:..|           .::.|.:.||:
Zfish   282 NTANPSVPALNVKPTNQSAVAPQQAGASSNPPSSSPTPSLPLSQLLLSQSGLHQTRGVPGSTATV 346

  Fly   165 NSLTVETSNKP-----------------------IQP----GGSAAAAAVGGGTGGAPL---TLV 199
            ..:.|.|||.|                       :||    |.:.:...:..|||..|:   |..
Zfish   347 THILVPTSNVPTSTQGYPLGTVATKSNMTAQTLVVQPLQQTGANLSTEKLAHGTGHVPIQPKTAQ 411

  Fly   200 GKTV--------------VPPKIQAAT----PVQIPSTGPGAQVSLLANPLKPRAPLILSKVAVD 246
            |..|              .||....||    |..:|....||:.|.|.|.         ..:|:.
Zfish   412 GHRVPVQMSPRHPPPILPAPPNNGQATAGLHPPHVPVQLVGARQSTLGNS---------QALALA 467

  Fly   247 KLRLKFSQVKSNPNALVLGKANHVKKLLTSPNPSGEDKTRSTQKNNKQNTSASQLKPVVAPKTAM 311
            :.|...|| :....|:.:....:|..::|:.:.||......|                  .::|:
Zfish   468 QARTCCSQ-QDGTAAVGVNNPGNVVTMVTAMDTSGAGMCLKT------------------AQSAL 513

  Fly   312 PIATEVPTADNNKMSLIKSKPVAI-----------KAVPLPSQEAPIVPAVAPVVT--------- 356
            || :::.|  |....|.:..|.::           .::.:.|.:|.|.||:.|:..
Zfish   514 PI-SQMQT--NQSAVLSQGNPASVTHSMDGQNNSGDSLFVQSAQAQIKPAIGPIKRKSESDLTHE 575

  Fly   357 --------SPEKVDVKP--TAKPSIKTAPK---PTPKPLEMSV-----NGPAKEKKAPAKEQKQK 403
                    ||...|..|  :..||:.|.|:   .:|..|.:|:     .|..:..:||..:
Zfish   576 ISNEPISGSPSMQDSAPPLSPAPSLDTVPEIAFSSPPTLSLSLPLPLPRGAGQGDRAPVPQ---- 636

  Fly   404 TMDKPPVVKEIAQHTPCGPKELPKLKRSKSFVSNHPASPVANNERRHSVAIMAKEVDVIEQPSAA 468
            .:.||.|:..:.:                .||....|.|       ..|....||:      |.|
Zfish   637 AVVKPQVLTHLIE----------------GFVIQEGAEP-------FPVTGPLKEL------SGA 672

  Fly   469 IETITIEDDDESEEEQQKPEIKKTPKQNQKPEKQ----EAPKKKQIPM------------PILPA 517
            :..|...:|..|::.:.:..:...|....:..|:    ...|:..:..            ...||
Zfish   673 VPPILHPEDIRSDKLKCEYCLNFAPASQFRRSKRFCTISCSKRYNVSFRNHLRASRGLEGAERPA 737

  Fly   518 GITISTTSTAKKKAVRKNSSVTTISSSS---------SDSSSYSDVEVVPTKKTEKELSMLPGIS 573
            |..:.....|:::|.|::||....:..:         |:||...|:.....::.|..||:.|..:
Zfish   738 GGPVVQDVIARRRAPRRSSSEIACAKITGRHLPVKCRSESSRSDDISSCEGEEEEDFLSLSPSST 802

  Fly   574 IIKAESLPLSREDFERSLRCDEQVPQTPP 602
            .    |.|       |...|..|:..|.|
Zfish   803 F----SCP-------RPTHCGPQLDDTAP 820

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)mbt	NP_733209.1	MBT	822..918	CDD:214723
		MBT	929..1028	CDD:214723
		MBT	1038..1130	CDD:214723
		SAM_PNT	1279..1366	CDD:280377
phc1	XP_005158395.1	PHC2_SAM_assoc	<763..832	CDD:293222	15/69 (22%)
		SAM_Ph1,2,3	834..901	CDD:188976
		SAM	835..901	CDD:197735
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583953
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840