Protein Alignment l(3)mbt and Sfmbt

DIOPT Version :10

• Sequence 1: NP_733209.1
• Gene: l(3)mbt / 43288
• FlyBaseID: FBgn0002441
• Length: 1477
• Species: Drosophila melanogaster
• Sequence 2: NP_001137821.1
• Gene: Sfmbt / 34709
• FlyBaseID: FBgn0032475
• Length: 1243
• Species: Drosophila melanogaster
• Alignment Length: 1221
• Identity: 249/1221 - (20%)
• Similarity: 409/1221 - (33%)
• Gaps: 442/1221 - (36%)

  Fly   468 AIETITIED-----------DDESEEEQQKPEI-------------------------KKTPKQN 496
            |:|.:..:|           ||...|.:.|.||                         .|...|:
  Fly   130 AMEAVVDDDDQVYGQRDNNFDDNGSELEPKQEIINIDDFVMMNEDNNSYDGTDFMTSSDKDISQS 194

  Fly   497 ------QKPEKQEAPKKKQ---IPMP------------ILPA----------GITISTTSTAKKK 530
                  |.|.....|..:.   :|:|            ::||          .|.:||.:|:.|:
  Fly   195 SSSCMAQMPGSLGVPGVEHDLLVPLPDGLLHHKLLGTTLVPAMGTLNGNAFGNIMVSTENTSSKQ 259

  Fly   531 AVR-------KNSSVTTISSSSSDSSSYSDVEVVPTKKTEK-ELSMLPGISI---------IKAE 578
            ..|       .||:.||.:.|:|.||:...     .:||.| |....||:.:         |...
  Fly   260 MQRTYSTAKGANSTATTATCSASTSSALRS-----QRKTRKIEPVNRPGLVLKTPIAYRGNIDPS 319

  Fly   579 SLPLSREDFERSLRCDE-QVPQT-PPKS----SSSSSSGSHASEMSPPPKLADPKPSSPPAKNAK 637
            .:|:.::......||.. .|..| ..||    |.:.:.|...|.:.......|...:|.|
  Fly   320 VIPIQKDGMAVCKRCGAIGVKHTFYTKSRRFCSMACARGELYSLVLNTKMEGDQATTSSP----- 379

  Fly   638 KANDHDANPSPSSKTNDFKKSMMQNLNMLKWRGQQPANLQNSTVRFEL-NEFNFLQINERCQPRQ 701
                   :|...|::.|......|:.:.:: .....|:::|:..||.: ::....|:|...:|..
  Fly   380 -------DPGAGSESADLPGDQQQSQSDIE-LDLHAAHIKNANYRFRITDQSKITQLNSFGEPMS 436

  Fly   702 --GPAAYFERPLYDRPGRRPSACVHPLLYLCQRCNFHGPAAD--FLAPHFCSVGCVRRSQKRRLP 762
              |.||                           .|....|||  ..|.:..:||      ....|
  Fly   437 MGGDAA---------------------------ANNVQMAADETIAALNGGAVG------DATAP 468

  Fly   763 QSTQKESKISRTQLEQTAGTAP-------------DLPQKRQTNYKP------HKSLSAIQEQLQ 808
            .||::.:....:.|  :|...|             ||||..:....|      .|.:|     ::
  Fly   469 GSTEEGASTPNSYL--SAAPTPKALRLFKDIYPQDDLPQIPKYERLPVPCPQMEKIIS-----IR 526

  Fly   809 QRQKDKPRKPFRWSEYLKSKGKDVAAPIHLFLNPFPISPNC-----FEIGMK----------LEA 858
            :|..| |...:.|...| ||....|||:    ..||.:|.|     ..:|||          :|.
  Fly   527 RRMYD-PTHSYDWLPRL-SKENFNAAPV----TCFPHAPGCEVWDNLGVGMKVEVENTDCDSIEV 585

  Fly   859 IDP-ENCSLFCVCSIVEVRGYRLKLSFDGY-SSMYDFWVNADSQDIFPPGWCDETARVLQAPKDY 921
            |.| :..:.|.|.:|:|::||:..:|::|: :..:|||||..:.::...|||....:.|..|:..
  Fly   586 IQPGQTPTSFWVATILEIKGYKALMSYEGFDTDSHDFWVNLCNAEVHSVGWCATRGKPLIPPRTI 650

  Fly   922 NSERFSWSRYLV--KTGGKAAPRALFGHLNMQQQMDVRNGFAVGMHLEAEDLNDTGKICVATVTD 984
            ..:...|..:||  .:|.:..|...:..:|...|    :.|.:|::||..|.:...::.:||||.
  Fly   651 EHKYKDWKDFLVGRLSGARTLPSNFYNKINDSLQ----SRFRLGLNLECVDKDRISQVRLATVTK 711

  Fly   985 ILDERIRVHFDGWDDCYDLWVHITSPYIHPCGW-----HE-------------GRQQLI------ 1025
            |:.:|:.:.:...||.:  |.|..||.|||.||     |.             ||:.:|
  Fly   712 IVGKRLFLRYFDSDDGF--WCHEDSPIIHPVGWATTVGHNLAAPQDYLERMLAGREAMIEVHEDD 774

  Fly  1026 ----------------------------------------------------------------- 1025
                                                                             
  Fly   775 ATIELFKMNFTFDEYYSDGKTNSFVEGMKLEAVDPLNLSSICPATVMAVLKFGYMMIRIDSYQPD 839

  Fly  1026 -----------------------------VPPD-YQKSAFIWDDYISEVGGMAASKELFTPRQPM 1060
                                         .||: |....|.|:.|:.:.|.:||.:.||....|.
  Fly   840 ASGSDWFCYHEKSPCIFPAGFCSVNNISVTPPNGYDSRTFTWEGYLRDTGAVAAGQHLFHRIIPD 904

  Fly  1061 E-YQERMKLEVVDQRNPCLIRPATVVTRKGYRVQLHLDCWPTEYYFWLEDDSPDLHPIGWCEATS 1124
            . ::..|.||..|..:|.|:..|||....|..:::|.|.|..||..||:.:|.|::|:|||...:
  Fly   905 HGFEVGMSLECADLMDPRLVCVATVARVVGRLLKVHFDGWTDEYDQWLDCESADIYPVGWCVLVN 969

  Fly  1125 HELETPPGYLQPKSVMPCDVEGCRGFGNAKRFNLNVHALRECCPYAPENWRQWRSKTVKPPRVAP 1189
            |:||.||                                              |....:.|:.||
  Fly   970 HKLEGPP----------------------------------------------RVAHQQAPKPAP 988

  Fly  1190 E-NIRRGWAKKTKRACSEAK-------QAIKEDSQQEIVYPKVAEVVQAKRKTSPCEEKVVKKQK 1246
            : .|:|  .:|.|:..:..|       |::|..:......|.:.: :..|.:..|........:.
  Fly   989 KPKIQR--KRKPKKGAAGGKTPTDNNTQSVKSRTIALKTTPHLPK-LSIKLELKPEHHNAAFYEN 1050

  Fly  1247 QMQKEEDAEQVPD-------------ERSL-----------------------------AIARSF 1269
            ...:||..|:.||             |:|.                             .:.:|.
  Fly  1051 NQPEEEGDEEDPDADGDGDGSTSHISEQSTTQSSSDLIAGSGSGSGSASLVTLATGSNKTVKKST 1115

  Fly  1270 VKDYGP--------QFLPNYRLWQLNSAFKLDDVRTNPLH-------WTSWDVCEYIERALDSTD 1319
            .|...|        .::.|..........:|.|:.::..|       |..:||.::: |..|.|.
  Fly  1116 TKSPAPPTVGRKATSYIANSSATNNKYIPRLADIDSSEPHLELVPDTWNVYDVSQFL-RVNDCTA 1179

  Fly  1320 IAKVIFEQDIDGRALLMLGRKELDTYLKLKVGPAVKLYSLILNLRIAVVCK 1370
            .........|||:.||.|.:.::...|.:|||||:|:..||..|:    ||
  Fly  1180 HCDTFSRNKIDGKRLLQLTKDDIMPLLGMKVGPALKISDLIAQLK----CK 1226

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(3)mbt	NP_733209.1	PRK10819	<332..>427	CDD:236768
		MBT_L3MBTL1-like_rpt1	846..945	CDD:439091	31/117 (26%)
		MBT_L3MBTL1-like_rpt2	957..1045	CDD:439092	32/206 (16%)
		MBT_L3MBTL1-like_rpt3	1058..1130	CDD:439093	27/72 (38%)
		SAM_PNT	1278..1367	CDD:460486	26/95 (27%)
Sfmbt	NP_001137821.1	MBT_dSfmbt_rpt1	564..672	CDD:439109	28/107 (26%)
		MBT_dSfmbt_rpt2	674..753	CDD:439112	25/84 (30%)
		MBT_dSfmbt_rpt3	798..904	CDD:439115	11/105 (10%)
		MBT_dSfmbt_rpt4	905..976	CDD:439118	26/70 (37%)
		SAM_Scm-like-4MBT	1160..1226	CDD:188979	22/70 (31%)