Protein Alignment l(3)mbt and Phc2

DIOPT Version :10

• Sequence 1: NP_733209.1
• Gene: l(3)mbt / 43288
• FlyBaseID: FBgn0002441
• Length: 1477
• Species: Drosophila melanogaster
• Sequence 2: NP_001013187.2
• Gene: Phc2 / 313038
• RGDID: 1307912
• Length: 850
• Species: Rattus norvegicus
• Alignment Length: 752
• Identity: 161/752 - (21%)
• Similarity: 261/752 - (34%)
• Gaps: 250/752 - (33%)

  Fly     5 SMASAEAKQLQRNISLSMSPANGGVI----SPSTANCNGVASAS---GGNPNPNSLLTLAP---R 59
            |..|::|.....:::|:.|||...:|    |.::|..:|:|..:   |...:|....:.|.   |
  Rat   125 SSVSSQAPAQSSSLNLAASPAAAQLINRAQSVNSATASGLAQQAVLLGNTSSPALTASQAQMYLR 189

  Fly    60 KEELRFLPLAPMGGNKTCNITISNVQ-----------PMKSKLKSVNIVPNSIKSAGAGATVGSA 113
            .:.|.|.|.|          |::.||           |..::::::.:......:|.|.|....
  Rat   190 AQMLIFTPTA----------TVATVQPELGTGSPARPPTPAQVQNLTLRTQQTPAAAAAAAASG- 243

  Fly   114 DAPLFQLVPSPSNPSQPLVAILAPNRKTTLLGGGASNGQPV-------VIRSGTPLHKNSLTVET 171
                    |:|:.|..|.:|:     |.|     .|:.||:       .:..|:|:.......:.
  Rat   244 --------PAPTQPVLPSLAL-----KPT-----PSSSQPLPPTPQGRTVVQGSPVGAKPSVTDN 290

  Fly   172 SNKPIQPGGSAAAAAVGGGTGGAPLTLVGKTVVPPKIQAATPVQI---PST-GPGAQVSLLANPL 232
            ..:|::..|::...|..|.......|:....:..|......|.|:   ||: .|..|......|.
  Rat   291 VTEPLKTDGNSNMEARPGPDRATVPTVATHQLTAPAYTQLQPHQLLPQPSSKHPQPQFVAQQQPQ 355

  Fly   233 KPR-APLILSKVAVDKLRLKFS-QVKSNPNALVLGKAN----------HVKKLLTS-----PNP- 279
            .|| .|.:.|:..:..:....: |.....:|:.||...          ||.|..:|     |.|
  Rat   356 PPRPTPQVQSQPQLAAVSPSLALQPSPEGHAMPLGPVTQALPLQCSTAHVHKPGSSQQCHLPTPD 420

  Fly   280 SG------EDKTRSTQKNNKQNTSA--SQLKPV------VAP---KTAMPIATEVPTADNNKMSL 327
            ||      |..:.:.|: ..|:|||  .||:|.      .||   |..:|....||.   .:..|
  Rat   421 SGSQNGHPEGVSHAPQR-RFQHTSAVILQLQPASPVPQQCAPDDWKEVVPAEKSVPV---TRPGL 481

  Fly   328 IKSKPVAIKAVP--LPSQEAP-------------IVPAV----APVVTS-------------PEK 360
            ...:...|.|:|  ||..::|             ||.|:    :|.:||             |:.
  Rat   482 SPHQQAIITAIPGGLPGPKSPNIQQCPAHETGQGIVHALTDLSSPGMTSGNGNSASSITGTAPQN 546

  Fly   361 VDVKP---TAKPSIKT----------APKPTPKPLEMSVNGPAKEK--------KAPAKEQKQKT 404
            .:.||   ..||.|.|          ..:|.|......:.|..|:|        |.|.::....|
  Rat   547 GENKPPQAIVKPQILTHVIEGFVIQEGAEPFPVGRSSLLVGNLKKKYAQGFLPEKLPQQDHTTTT 611

  Fly   405 ---MDKPPVVKEIAQHTP-------CGPKELP-KLKRSKSFVSNHPASPVANNERRHSVAIMAKE 458
               |::|.:.:...:.||       ||..:.. |.||||.|.|...|       :|::|. ..|.
  Rat   612 DSEMEEPYLQESKEEGTPLKLKCELCGRVDFAYKFKRSKRFCSMACA-------KRYNVG-CTKR 668

  Fly   459 VDVIEQPSAAIETITIEDDDESEEEQQKPEIKKTPKQNQKPEKQEAPKKKQIPMPILPAGITIST 523
            |.:..             .|.|:.::                                ||.|...
  Rat   669 VGLFH-------------SDRSKLQK--------------------------------AGTTTHN 688

  Fly   524 TSTAKKKAVRKNSSVTTISSSSSDSSSYSDVEVVPTKKTEKELSMLPGISIIKAESLPLSREDFE 588
            ...|.|      :|:.|:                 ||.|:|:.|....:|:..|..|..|:||
  Rat   689 RRRASK------ASLPTL-----------------TKDTKKQPSGTVPLSVTAALQLAHSQED-- 728

  Fly   589 RSLRCDE----QVPQTPPKSSSSSS---SGSHASEMS 618
             |.||.:    :.|.:|..:|||:|   .|....|:|
  Rat   729 -SSRCSDNSSYEEPLSPISASSSTSRRRQGQRDLELS 764

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(3)mbt	NP_733209.1	PRK10819	<332..>427	CDD:236768	33/158 (21%)
		MBT_L3MBTL1-like_rpt1	846..945	CDD:439091
		MBT_L3MBTL1-like_rpt2	957..1045	CDD:439092
		MBT_L3MBTL1-like_rpt3	1058..1130	CDD:439093
		SAM_PNT	1278..1367	CDD:460486
Phc2	NP_001013187.2	Herpes_BLLF1	<141..559	CDD:282904	96/450 (21%)
		PHC2_SAM_assoc	662..781	CDD:465202	35/175 (20%)
		SAM_Ph1,2,3	781..849	CDD:188976