DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(3)mbt and Phc3

DIOPT Version :9

Sequence 1:	NP_733209.1	Gene:	l(3)mbt / 43288	FlyBaseID:	FBgn0002441	Length:	1477	Species:	Drosophila melanogaster
Sequence 2:	XP_006232288.1	Gene:	Phc3 / 310258	RGDID:	1307998	Length:	1011	Species:	Rattus norvegicus

Alignment Length:	1021	Identity:	191/1021 - (18%)
Similarity:	340/1021 - (33%)	Gaps:	337/1021 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PLSMASAEAKQLQRNISLSMSPANGGVISPSTANCNGVASASG---------GNPNPNSLLTLAP 58
            |....:.::...|.:|:||.||....::|.|.|:    :|.||         |:.:|....:.|.
  Rat   123 PTGSVTQQSSMSQTSINLSTSPTPAQLMSRSQAS----SSTSGSITQQTMLLGSTSPTLTASQAQ 183

  Fly    59 ---RKEELRF------------LPLAPMGGNKTCNITISNVQPMKSKLKSVNIVPNS----IKSA 104
               |.:.|.|            :|:.....:.:|....:.||.:..:.:.:.::.:|    .|||
  Rat   184 MYLRAQMLIFTPATTVAAVQSDIPVVSSSPSPSCQSAAAQVQNLTLRSQKLGVLSSSQNGPPKSA 248

  Fly   105 GA---------GATVGSADAPLFQLVPSPSNP----------------SQPLVAILAPNRKTTLL 144
            |.         ..||.|  :.:.|..|||.:.                :..:..::||...:.:.
  Rat   249 GQTQSLTICHNKTTVTS--SKISQRDPSPESKKGGSPGLESRSTAVTRTSSIHQLIAPASYSPIQ 311

  Fly   145 GGGASNGQPVVIRSGTP-LHKNSLTVETSNKPIQPGGSAAAAAVGGGTGGAPLTLVGKTVVPPKI 208
            .......|.:.:.|..| :..:.|.::...:.||                 |:||...:..||..
  Rat   312 PHSLIKHQQIPLHSPPPKVSHHQLILQQQQQQIQ-----------------PITLQSPSQDPPPS 359

  Fly   209 QAATPVQIPSTG-----PGAQVSLLANPLKPRAPLILSKVAVDKLRLKFSQVKSNPNALVLGKAN 268
            |...|  :|:.|     ..||.....:|::...|         .|.:..||.:|...::|:
  Rat   360 QHCIP--LPNHGLSPASSNAQSQQHCSPIQSHPP---------PLTVSPSQAQSAQQSVVV---- 409

  Fly   269 HVKKLLTSPNPSGEDKTRSTQKNNKQNTSASQLKPVVAPKTAMPIATEVPTADNNKMSLIKSKPV 333
                   ||.|:.......|...:.|  :..|..|:|:.........:..|||..:.:...:.|
  Rat   410 -------SPPPAHSPSQSPTIIIHPQ--ALVQPHPLVSSALHTGPNLQQATADQVQSTAQLNLP- 464

  Fly   334 AIKAVPLPSQEAPIV---PAVAPVVTSPEKVDVKPTAK---PSIKTAPKPTPKPLEMSVNGPAKE 392
              ..:|||:  :|:|   |.....:.||.:..|.||:.   .:::::|.|...|.:||.:.||:.
  Rat   465 --SHLPLPA--SPVVHIGPVQQSALVSPGQQIVSPTSHQQYSTLQSSPIPIATPPQMSASPPAQI 525

  Fly   393 KKAPAKEQKQKTMDKPPVVKE---IAQHTPCGPKELPKLKR--SKSFVSNHPASPVANNERRHSV 452
            ...|. :..|....:|.::.:   :.|:.....:|||..:.  ...|.:..|...||
  Rat   526 PPLPL-QSMQSLQVQPEILSQGQVLVQNALVSEEELPAAEALVQLPFQTLPPPQTVA-------- 581

  Fly   453 AIMAKEVDVIEQPSAAIE----------------TITI-EDDDESEEEQQKPEIKKTPKQNQKPE 500
                  |::..||.|.::                ::.: :.:|..|||  :||           |
  Rat   582 ------VNLQVQPPAPVDPPVGMHLNQCHLHKVFSLKVYQVEDVCEEE--RPE-----------E 627

  Fly   501 KQEAPKKKQIPMP--ILPAGITISTTS--TAKKKAVRKNSSVTTISSSSSDSSSYSDVEVVPTKK 561
            ..|..:..:.|.|  :.||.||:....  |::...:.:.......|.|:|...|.||    ||.
  Rat   628 SDECARMDRTPPPPTLSPAAITVGRGEDLTSEHPLLEQVELPAVASVSASVIKSPSD----PTH- 687

  Fly   562 TEKELSMLPGISIIKAESLPLSREDFERSLRCDEQVPQTPPKSSSSSSSGSHASEMSPPPKLADP 626
                         :.|.:.||             .:|....:|||:|.:.|..|..:.||:
  Rat   688 -------------VSAPAPPL-------------LMPAASTRSSSTSLASSTPSLENKPPQ---- 722

  Fly   627 KPSSPPAKNAKKANDHDANPSPSSKTNDFKKSMMQNLNMLKWRGQQPANLQNSTVRFELNEFNFL 691
                             |...|...|:..:..::|       .|.:|..:..|::..|
  Rat   723 -----------------AIVKPQILTHVIEGFVIQ-------EGLEPFPVSRSSLLIE------- 756

  Fly   692 QINERCQPRQGPAAYFERPLYDRPGRRPSACVHP------------------------------- 725
                  ||.:      :|||.|..... |.||.|
  Rat   757 ------QPVK------KRPLLDNQVVN-SVCVQPELQNNTKHADNSSDTEMEDMIAEETLEEMDS 808

  Fly   726 LLYLCQRCNFHGPAADFL-APHFCSVGCVRR-----SQKRRL---------------------PQ 763
            .|..|:.|...|...:|| :..||::.|.:|     |:|..|                     |:
  Rat   809 ELLKCEFCGKMGYPNEFLRSKRFCTMSCAKRYNVSCSKKFALSRWNRKPDNQSLGHRGRRPSGPE 873

  Fly   764 STQKESKISRTQL------EQTAGTAPDLPQ------KRQTNYKPHKSLSAIQEQLQQRQKD--- 813
            ...:|..:.:..:      |..|.....:|.      :||:..:..:.|..::.:......|
  Rat   874 GAAREHILRQLPITYPSAEEDLASRDDPVPSAMTTRLRRQSERERERELRDVRIRKMPENSDLLP 938

  Fly   814 -KPRKPFRWSEYLKSKGKDVAAPIHLFLNPFPISPNCFEIGMKLEA 858
             ...:|..|:.      .||.|.||..       |.|.::..:..|
  Rat   939 VAQTEPSIWTV------DDVWAFIHSL-------PGCQDVADEFRA 971

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)mbt	NP_733209.1	MBT	822..918	CDD:214723	8/37 (22%)
		MBT	929..1028	CDD:214723
		MBT	1038..1130	CDD:214723
		SAM_PNT	1279..1366	CDD:280377
Phc3	XP_006232288.1	SAM_Ph1,2,3	942..1010	CDD:188976	10/43 (23%)
Phc3	XP_006232288.1	SAM	944..1011	CDD:197735	10/41 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910