Protein Alignment l(3)mbt and Phc3

DIOPT Version :10

• Sequence 1: NP_733209.1
• Gene: l(3)mbt / 43288
• FlyBaseID: FBgn0002441
• Length: 1477
• Species: Drosophila melanogaster
• Sequence 2: XP_006232288.1
• Gene: Phc3 / 310258
• RGDID: 1307998
• Length: 1011
• Species: Rattus norvegicus
• Alignment Length: 1021
• Identity: 191/1021 - (18%)
• Similarity: 340/1021 - (33%)
• Gaps: 337/1021 - (33%)

  Fly     3 PLSMASAEAKQLQRNISLSMSPANGGVISPSTANCNGVASASG---------GNPNPNSLLTLAP 58
            |....:.::...|.:|:||.||....::|.|.|:    :|.||         |:.:|....:.|.
  Rat   123 PTGSVTQQSSMSQTSINLSTSPTPAQLMSRSQAS----SSTSGSITQQTMLLGSTSPTLTASQAQ 183

  Fly    59 ---RKEELRF------------LPLAPMGGNKTCNITISNVQPMKSKLKSVNIVPNS----IKSA 104
               |.:.|.|            :|:.....:.:|....:.||.:..:.:.:.::.:|    .|||
  Rat   184 MYLRAQMLIFTPATTVAAVQSDIPVVSSSPSPSCQSAAAQVQNLTLRSQKLGVLSSSQNGPPKSA 248

  Fly   105 GA---------GATVGSADAPLFQLVPSPSNP----------------SQPLVAILAPNRKTTLL 144
            |.         ..||.|  :.:.|..|||.:.                :..:..::||...:.:.
  Rat   249 GQTQSLTICHNKTTVTS--SKISQRDPSPESKKGGSPGLESRSTAVTRTSSIHQLIAPASYSPIQ 311

  Fly   145 GGGASNGQPVVIRSGTP-LHKNSLTVETSNKPIQPGGSAAAAAVGGGTGGAPLTLVGKTVVPPKI 208
            .......|.:.:.|..| :..:.|.::...:.||                 |:||...:..||..
  Rat   312 PHSLIKHQQIPLHSPPPKVSHHQLILQQQQQQIQ-----------------PITLQSPSQDPPPS 359

  Fly   209 QAATPVQIPSTG-----PGAQVSLLANPLKPRAPLILSKVAVDKLRLKFSQVKSNPNALVLGKAN 268
            |...|  :|:.|     ..||.....:|::...|         .|.:..||.:|...::|:
  Rat   360 QHCIP--LPNHGLSPASSNAQSQQHCSPIQSHPP---------PLTVSPSQAQSAQQSVVV---- 409

  Fly   269 HVKKLLTSPNPSGEDKTRSTQKNNKQNTSASQLKPVVAPKTAMPIATEVPTADNNKMSLIKSKPV 333
                   ||.|:.......|...:.|  :..|..|:|:.........:..|||..:.:...:.|
  Rat   410 -------SPPPAHSPSQSPTIIIHPQ--ALVQPHPLVSSALHTGPNLQQATADQVQSTAQLNLP- 464

  Fly   334 AIKAVPLPSQEAPIV---PAVAPVVTSPEKVDVKPTAK---PSIKTAPKPTPKPLEMSVNGPAKE 392
              ..:|||:  :|:|   |.....:.||.:..|.||:.   .:::::|.|...|.:||.:.||:.
  Rat   465 --SHLPLPA--SPVVHIGPVQQSALVSPGQQIVSPTSHQQYSTLQSSPIPIATPPQMSASPPAQI 525

  Fly   393 KKAPAKEQKQKTMDKPPVVKE---IAQHTPCGPKELPKLKR--SKSFVSNHPASPVANNERRHSV 452
            ...|. :..|....:|.::.:   :.|:.....:|||..:.  ...|.:..|...||
  Rat   526 PPLPL-QSMQSLQVQPEILSQGQVLVQNALVSEEELPAAEALVQLPFQTLPPPQTVA-------- 581

  Fly   453 AIMAKEVDVIEQPSAAIE----------------TITI-EDDDESEEEQQKPEIKKTPKQNQKPE 500
                  |::..||.|.::                ::.: :.:|..|||  :||           |
  Rat   582 ------VNLQVQPPAPVDPPVGMHLNQCHLHKVFSLKVYQVEDVCEEE--RPE-----------E 627

  Fly   501 KQEAPKKKQIPMP--ILPAGITISTTS--TAKKKAVRKNSSVTTISSSSSDSSSYSDVEVVPTKK 561
            ..|..:..:.|.|  :.||.||:....  |::...:.:.......|.|:|...|.||    ||.
  Rat   628 SDECARMDRTPPPPTLSPAAITVGRGEDLTSEHPLLEQVELPAVASVSASVIKSPSD----PTH- 687

  Fly   562 TEKELSMLPGISIIKAESLPLSREDFERSLRCDEQVPQTPPKSSSSSSSGSHASEMSPPPKLADP 626
                         :.|.:.||             .:|....:|||:|.:.|..|..:.||:
  Rat   688 -------------VSAPAPPL-------------LMPAASTRSSSTSLASSTPSLENKPPQ---- 722

  Fly   627 KPSSPPAKNAKKANDHDANPSPSSKTNDFKKSMMQNLNMLKWRGQQPANLQNSTVRFELNEFNFL 691
                             |...|...|:..:..::|       .|.:|..:..|::..|
  Rat   723 -----------------AIVKPQILTHVIEGFVIQ-------EGLEPFPVSRSSLLIE------- 756

  Fly   692 QINERCQPRQGPAAYFERPLYDRPGRRPSACVHP------------------------------- 725
                  ||.:      :|||.|..... |.||.|
  Rat   757 ------QPVK------KRPLLDNQVVN-SVCVQPELQNNTKHADNSSDTEMEDMIAEETLEEMDS 808

  Fly   726 LLYLCQRCNFHGPAADFL-APHFCSVGCVRR-----SQKRRL---------------------PQ 763
            .|..|:.|...|...:|| :..||::.|.:|     |:|..|                     |:
  Rat   809 ELLKCEFCGKMGYPNEFLRSKRFCTMSCAKRYNVSCSKKFALSRWNRKPDNQSLGHRGRRPSGPE 873

  Fly   764 STQKESKISRTQL------EQTAGTAPDLPQ------KRQTNYKPHKSLSAIQEQLQQRQKD--- 813
            ...:|..:.:..:      |..|.....:|.      :||:..:..:.|..::.:......|
  Rat   874 GAAREHILRQLPITYPSAEEDLASRDDPVPSAMTTRLRRQSERERERELRDVRIRKMPENSDLLP 938

  Fly   814 -KPRKPFRWSEYLKSKGKDVAAPIHLFLNPFPISPNCFEIGMKLEA 858
             ...:|..|:.      .||.|.||..       |.|.::..:..|
  Rat   939 VAQTEPSIWTV------DDVWAFIHSL-------PGCQDVADEFRA 971

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(3)mbt	NP_733209.1	PRK10819	<332..>427	CDD:236768	25/103 (24%)
		MBT_L3MBTL1-like_rpt1	846..945	CDD:439091	3/13 (23%)
		MBT_L3MBTL1-like_rpt2	957..1045	CDD:439092
		MBT_L3MBTL1-like_rpt3	1058..1130	CDD:439093
		SAM_PNT	1278..1367	CDD:460486
Phc3	XP_006232288.1	Atrophin-1	311..>596	CDD:460830	69/345 (20%)
		SAM_Ph1,2,3	942..1010	CDD:188976	10/43 (23%)