DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(3)mbt and L3MBTL1

DIOPT Version :9

Sequence 1:	NP_733209.1	Gene:	l(3)mbt / 43288	FlyBaseID:	FBgn0002441	Length:	1477	Species:	Drosophila melanogaster
Sequence 2:	NP_001364232.1	Gene:	L3MBTL1 / 26013	HGNCID:	15905	Length:	862	Species:	Homo sapiens

Alignment Length:	949	Identity:	264/949 - (27%)
Similarity:	399/949 - (42%)	Gaps:	228/949 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   551 YSDVEVVPTKK--TEKELSM-------------LPGIS-IIKAES----LPLSRED---FERS-- 590
            ::::|::.|.|  :..|:||             ||..: ||.|.|    ||.|..|   |.|.
Human     4 HAEMEMLRTLKGPSTGEVSMHLVAGDSPGSGPHLPATAFIIPASSATLGLPSSALDVSCFPREPI 68

  Fly   591 -LRCDEQV-----------PQTPPKSSSSSSSGSHASE----MSPPP------KLADPKP----- 628
             :...|||           ||.....:|||:|.....|    .:|||      ::::.||
Human    69 HVGAPEQVAGCEPVSATVLPQLSAGPASSSTSTVRLLEWTEAAAPPPGGGLRFRISEYKPLNMAG 133

  Fly   629 -SSPPAKNAKK------------ANDHDANPSPSSKTNDFKKSMMQNLNMLKWRGQQPANLQNST 680
             ..||:...::            |.|.:|.|   .:..|..::..::.|      |.|.. .:||
Human   134 VEQPPSPELRQEGVTEYEDGGAPAGDGEAGP---QQAEDHPQNPPEDPN------QDPPE-DDST 188

  Fly   681 VRFELNEFNFLQINERCQPRQ--GPAAYFERPLYDRPGRRPSACVHPLLY-----LCQRCNFHGP 738
            .:.           :.|.|.|  ||..          |.....|  |.|:     :.:..:....
Human   189 CQC-----------QACGPHQAAGPDL----------GSSNDGC--PQLFQERSVIVENSSGSTS 230

  Fly   739 AADFLAPHFCSVGCVRRSQKRRLPQSTQKESKISRTQLEQTAGTAPDLPQKRQTNYKPHKSLSAI 803
            |::.|.|        .:.:|||..||..:|.            :.|:..:|::....|....:|.
Human   231 ASELLKP--------MKKRKRREYQSPSEEE------------SEPEAMEKQEEGKDPEGQPTAS 275

  Fly   804 QEQLQQRQKDKP-----RKPFRWSEYLKSKGKDVAAPIHLFLNPFPI--SPNCFEIGMKLEAIDP 861
            ..:.::....:|     ::.:.|..||:.: |.:.||:.||.:...:  :.|.|::|||||.|||
Human   276 TPESEEWSSSQPATGEKKECWSWESYLEEQ-KAITAPVSLFQDSQAVTHNKNGFKLGMKLEGIDP 339

  Fly   862 ENCSLFCVCSIVEVRGYRLKLSFDGYSSMYDFWVNADSQDIFPPGWCDETARVLQAPKDYNSERF 926
            ::.|::.:.::.||.||||:|.|||||..:||||||:|.||.|.||.::|...||.||.|..|.|
Human   340 QHPSMYFILTVAEVCGYRLRLHFDGYSECHDFWVNANSPDIHPAGWFEKTGHKLQPPKGYKEEEF 404

  Fly   927 SWSRYLVKTGGKAAPRALFGHLNMQQQMDVRNGFAVGMHLEAEDLNDTGKICVATVTDILDERIR 991
            |||:||..|..:|||:.||   ..|.......||.|||.|||.|..:...:|||:|||::|.|..
Human   405 SWSQYLRSTRAQAAPKHLF---VSQSHSPPPLGFQVGMKLEAVDRMNPSLVCVASVTDVVDSRFL 466

  Fly   992 VHFDGWDDCYDLWVHITSPYIHPCGWHEGRQQLIVPP-DY-QKSAFIWDDYISEVGGMAASKELF 1054
            ||||.|||.||.|...:||||||.||.:.:.:.:.|| || ....|.|:.|:.|.|..|.....|
Human   467 VHFDNWDDTYDYWCDPSSPYIHPVGWCQKQGKPLTPPQDYPDPDNFCWEKYLEETGASAVPTWAF 531

  Fly  1055 TPRQPMEYQERMKLEVVDQRNPCLIRPATVVTRKGYRVQLHLDCWPTEYYFWLEDDSPDLHPIGW 1119
            ..|.|..:...||||.||:|||.|||.|:|...:.:|:::|.|.|...|.||::.|.||:||.||
Human   532 KVRPPHSFLVNMKLEAVDRRNPALIRVASVEDVEDHRIKIHFDGWSHGYDFWIDADHPDIHPAGW 596

  Fly  1120 CEATSHELETPPGYLQPKSVMP-------------------------CDVEGCRGFGNAKRFNLN 1159
            |..|.|.|:.|.|..:|.|..|                         |...||.|.|:... ...
Human   597 CSKTGHPLQPPLGPREPSSASPGGCPPLSYRSLPHTRTSKYSFHHRKCPTPGCDGSGHVTG-KFT 660

  Fly  1160 VHALRECCPYAPENWRQW-----------RSKTVK--PPRVAPENIRR-GWAKKTKRACSEAKQA 1210
            .|.....||.|..|..:.           |.|.:.  .||..|.:..| |...|.::...|..|.
Human   661 AHHCLSGCPLAERNQSRLKAELSDSEASARKKNLSGFSPRKKPRHHGRIGRPPKYRKIPQEDFQT 725

  Fly  1211 IKEDSQQEIVYPKVAEVVQAKRKTSPCEEKVVKKQKQMQKEEDAEQVPDERSLAIARSFVKDYGP 1275
            :..|...:.::.. |......|..|.|            .|:..:.:|....:: |.:..|
Human   726 LTPDVVHQSLFMS-ALSAHPDRSLSVC------------WEQHCKLLPGVAGIS-ASTVAK---- 772

  Fly  1276 QFLPNYRLWQLNSAFKLDDVRTNPLHWTSWDVCEYIERALDSTDIAKVIFEQDIDGRALL----M 1336
                    |.::..|......|.         ||  ::|....|.|:::....:.|:.|:    .
Human   773 --------WTIDEVFGFVQTLTG---------CE--DQARLFKDEARIVRVTHVSGKTLVWTVAQ 818

  Fly  1337 LGRKELDTYLK-----LKVGPAVKLYSLILNLRIAVVCK 1370
            ||......:|:     |:.|    ::||:.:|...::.|
Human   819 LGDLVCSDHLQEGKGILETG----VHSLLCSLPTHLLAK 853

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)mbt	NP_733209.1	MBT	822..918	CDD:214723	45/97 (46%)
		MBT	929..1028	CDD:214723	45/98 (46%)
		MBT	1038..1130	CDD:214723	39/91 (43%)
		SAM_PNT	1279..1366	CDD:280377	18/95 (19%)
L3MBTL1	NP_001364232.1	PRK07764	<27..188	CDD:236090	37/170 (22%)
		MBT	299..396	CDD:214723	45/97 (46%)
		MBT	407..503	CDD:214723	45/98 (46%)
		MBT	515..607	CDD:214723	39/91 (43%)
		zf-C2HC	643..671	CDD:396216	8/28 (29%)
		SAM_superfamily	770..>798	CDD:417767	7/50 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149802
Domainoid	1	1.000	97	1.000	Domainoid score	I7260
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002225
OrthoInspector	1	1.000	-	-		otm41370
orthoMCL	1	0.900	-	-		OOG6_104389
Panther	1	1.100	-	-	O	PTHR12247
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5341
SonicParanoid	1	1.000	-	-		X1471
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.870