Protein Alignment l(3)mbt and L3MBTL1

DIOPT Version :10

• Sequence 1: NP_733209.1
• Gene: l(3)mbt / 43288
• FlyBaseID: FBgn0002441
• Length: 1477
• Species: Drosophila melanogaster
• Sequence 2: NP_001364232.1
• Gene: L3MBTL1 / 26013
• HGNCID: 15905
• Length: 862
• Species: Homo sapiens
• Alignment Length: 949
• Identity: 264/949 - (27%)
• Similarity: 399/949 - (42%)
• Gaps: 228/949 - (24%)

  Fly   551 YSDVEVVPTKK--TEKELSM-------------LPGIS-IIKAES----LPLSRED---FERS-- 590
            ::::|::.|.|  :..|:||             ||..: ||.|.|    ||.|..|   |.|.
Human     4 HAEMEMLRTLKGPSTGEVSMHLVAGDSPGSGPHLPATAFIIPASSATLGLPSSALDVSCFPREPI 68

  Fly   591 -LRCDEQV-----------PQTPPKSSSSSSSGSHASE----MSPPP------KLADPKP----- 628
             :...|||           ||.....:|||:|.....|    .:|||      ::::.||
Human    69 HVGAPEQVAGCEPVSATVLPQLSAGPASSSTSTVRLLEWTEAAAPPPGGGLRFRISEYKPLNMAG 133

  Fly   629 -SSPPAKNAKK------------ANDHDANPSPSSKTNDFKKSMMQNLNMLKWRGQQPANLQNST 680
             ..||:...::            |.|.:|.|   .:..|..::..::.|      |.|.. .:||
Human   134 VEQPPSPELRQEGVTEYEDGGAPAGDGEAGP---QQAEDHPQNPPEDPN------QDPPE-DDST 188

  Fly   681 VRFELNEFNFLQINERCQPRQ--GPAAYFERPLYDRPGRRPSACVHPLLY-----LCQRCNFHGP 738
            .:.           :.|.|.|  ||..          |.....|  |.|:     :.:..:....
Human   189 CQC-----------QACGPHQAAGPDL----------GSSNDGC--PQLFQERSVIVENSSGSTS 230

  Fly   739 AADFLAPHFCSVGCVRRSQKRRLPQSTQKESKISRTQLEQTAGTAPDLPQKRQTNYKPHKSLSAI 803
            |::.|.|        .:.:|||..||..:|.            :.|:..:|::....|....:|.
Human   231 ASELLKP--------MKKRKRREYQSPSEEE------------SEPEAMEKQEEGKDPEGQPTAS 275

  Fly   804 QEQLQQRQKDKP-----RKPFRWSEYLKSKGKDVAAPIHLFLNPFPI--SPNCFEIGMKLEAIDP 861
            ..:.::....:|     ::.:.|..||:.: |.:.||:.||.:...:  :.|.|::|||||.|||
Human   276 TPESEEWSSSQPATGEKKECWSWESYLEEQ-KAITAPVSLFQDSQAVTHNKNGFKLGMKLEGIDP 339

  Fly   862 ENCSLFCVCSIVEVRGYRLKLSFDGYSSMYDFWVNADSQDIFPPGWCDETARVLQAPKDYNSERF 926
            ::.|::.:.::.||.||||:|.|||||..:||||||:|.||.|.||.::|...||.||.|..|.|
Human   340 QHPSMYFILTVAEVCGYRLRLHFDGYSECHDFWVNANSPDIHPAGWFEKTGHKLQPPKGYKEEEF 404

  Fly   927 SWSRYLVKTGGKAAPRALFGHLNMQQQMDVRNGFAVGMHLEAEDLNDTGKICVATVTDILDERIR 991
            |||:||..|..:|||:.||   ..|.......||.|||.|||.|..:...:|||:|||::|.|..
Human   405 SWSQYLRSTRAQAAPKHLF---VSQSHSPPPLGFQVGMKLEAVDRMNPSLVCVASVTDVVDSRFL 466

  Fly   992 VHFDGWDDCYDLWVHITSPYIHPCGWHEGRQQLIVPP-DY-QKSAFIWDDYISEVGGMAASKELF 1054
            ||||.|||.||.|...:||||||.||.:.:.:.:.|| || ....|.|:.|:.|.|..|.....|
Human   467 VHFDNWDDTYDYWCDPSSPYIHPVGWCQKQGKPLTPPQDYPDPDNFCWEKYLEETGASAVPTWAF 531

  Fly  1055 TPRQPMEYQERMKLEVVDQRNPCLIRPATVVTRKGYRVQLHLDCWPTEYYFWLEDDSPDLHPIGW 1119
            ..|.|..:...||||.||:|||.|||.|:|...:.:|:::|.|.|...|.||::.|.||:||.||
Human   532 KVRPPHSFLVNMKLEAVDRRNPALIRVASVEDVEDHRIKIHFDGWSHGYDFWIDADHPDIHPAGW 596

  Fly  1120 CEATSHELETPPGYLQPKSVMP-------------------------CDVEGCRGFGNAKRFNLN 1159
            |..|.|.|:.|.|..:|.|..|                         |...||.|.|:... ...
Human   597 CSKTGHPLQPPLGPREPSSASPGGCPPLSYRSLPHTRTSKYSFHHRKCPTPGCDGSGHVTG-KFT 660

  Fly  1160 VHALRECCPYAPENWRQW-----------RSKTVK--PPRVAPENIRR-GWAKKTKRACSEAKQA 1210
            .|.....||.|..|..:.           |.|.:.  .||..|.:..| |...|.::...|..|.
Human   661 AHHCLSGCPLAERNQSRLKAELSDSEASARKKNLSGFSPRKKPRHHGRIGRPPKYRKIPQEDFQT 725

  Fly  1211 IKEDSQQEIVYPKVAEVVQAKRKTSPCEEKVVKKQKQMQKEEDAEQVPDERSLAIARSFVKDYGP 1275
            :..|...:.::.. |......|..|.|            .|:..:.:|....:: |.:..|
Human   726 LTPDVVHQSLFMS-ALSAHPDRSLSVC------------WEQHCKLLPGVAGIS-ASTVAK---- 772

  Fly  1276 QFLPNYRLWQLNSAFKLDDVRTNPLHWTSWDVCEYIERALDSTDIAKVIFEQDIDGRALL----M 1336
                    |.::..|......|.         ||  ::|....|.|:::....:.|:.|:    .
Human   773 --------WTIDEVFGFVQTLTG---------CE--DQARLFKDEARIVRVTHVSGKTLVWTVAQ 818

  Fly  1337 LGRKELDTYLK-----LKVGPAVKLYSLILNLRIAVVCK 1370
            ||......:|:     |:.|    ::||:.:|...::.|
Human   819 LGDLVCSDHLQEGKGILETG----VHSLLCSLPTHLLAK 853

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(3)mbt	NP_733209.1	PRK10819	<332..>427	CDD:236768
		MBT_L3MBTL1-like_rpt1	846..945	CDD:439091	52/98 (53%)
		MBT_L3MBTL1-like_rpt2	957..1045	CDD:439092	43/89 (48%)
		MBT_L3MBTL1-like_rpt3	1058..1130	CDD:439093	33/71 (46%)
		SAM_PNT	1278..1367	CDD:460486	18/97 (19%)
L3MBTL1	NP_001364232.1	PRK07764	<27..188	CDD:236090	37/170 (22%)
		MBT_L3MBTL1_rpt1	315..423	CDD:439121	53/107 (50%)
		MBT_L3MBTL1_rpt2	430..522	CDD:439124	43/91 (47%)
		MBT_L3MBTL1_rpt3	535..609	CDD:439127	34/73 (47%)
		zf-C2HC	643..671	CDD:460240	8/28 (29%)
		SAM_superfamily	770..>798	CDD:472832	7/50 (14%)