Protein Alignment: l(3)mbt and PHC2

• Sequence 1: NP_733209.1
• Gene: l(3)mbt
• FlyBaseID: FBgn0002441
• Length: 1477
• Species: Drosophila melanogaster
• Sequence 2: NP_932157.1
• Gene: PHC2
• HGNCID: 3183
• Length: 858
• Species: Homo sapiens
• Alignment Length: 990
• Identity: 187/991 (19%)
• Similarity: 318/991 (32%)
• Gaps: 309/991 (31%)

  Fly     2 LPLSMASAEAKQLQRNISLSMSPANGGVISPSTANCNGVASASGGNPNPN----SLLTLAPRKEE 62
            ||:...|:.|        .:.|..:|   :.|::.||.  |:|||:..|.    |:.:..|.::.
Human     5 LPVPHTSSSA--------CATSSTSG---ASSSSGCNN--SSSGGSGRPTGPQISVYSGIPDRQT 56

  Fly    63 LRFLPLAPMGGNKTCNITISNV---QPMKSKLKSVNIVPNSIKSAGAGATVGSADAPLFQLVPSP 124
            ::.:..|......|....:..:   |.....|::..:....:.||              ||
Human    57 VQVIQQALHRQPSTAAQYLQQMYAAQQQHLMLQTAALQQQHLSSA--------------QL---- 103

  Fly   125 SNPSQPLVAI----LAPNRKTTLLGGGASNGQPVVIRSGTPLHKNSLTVETS-------NKPIQP 178
                |.|.|:    |..||:      |:::|..|..::  |...:|:.:..|       |: .|.
Human   104 ----QSLAAVQQASLVSNRQ------GSTSGSNVSAQA--PAQSSSINLAASPAAAQLLNR-AQS 155

  Fly   179 GGSAAAAAVG------GGTGGAPLTL--------VGKTVVPPKIQAATPVQIPSTGPGAQVSLLA 229
            ..||||:.:.      |.|....||.        ....:..|....|| || |..|.|
Human   156 VNSAAASGIAQQAVLLGNTSSPALTASQAQMYLRAQMLIFTPTATVAT-VQ-PELGTG------- 211

  Fly   230 NPLKPRAPLILSKVAVDKLRLKFSQVKSNPNALVLGKANH---VKKLLTSPNPSGEDKTRS-TQK 290
            :|.:|..|     ..|..|.|:..|   .|.|...|....   :..|...|.|.|.....: .|.
Human   212 SPARPPTP-----AQVQNLTLRTQQ---TPAAAASGPTPTQPVLPSLALKPTPGGSQPLPTPAQS 268

  Fly   291 NNKQNTSASQLKPVVAPKTAMPIA-----TEVPTADNNKMSLIKSKPVAIKAVPLPSQEAPIVPA 350
            .|....|.:..||.:|.....|..     :.||.:...:..|.::.| |:.|.||      |.||
Human   269 RNTAQASPAGAKPGIADSVMEPHKKGDGNSSVPGSMEGRAGLSRTVP-AVAAHPL------IAPA 326

  Fly   351 VAPVVTSPEKVDVKPTAK---PSIKTAPKPTPKPLEMSVNGPAKEKKAP---AKEQKQKTMDKPP 409
            .|.:  .|.::..:|::|   |......:|.|:..:     |..::..|   |:...|.....|.
Human   327 YAQL--QPHQLLPQPSSKHLQPQFVIQQQPQPQQQQ-----PPPQQSRPVLQAEPHPQLASVSPS 384

  Fly   410 VVKE---------IAQHTPCGPKELPKLKRSKSFVSN--HPASPVANNERRHSVAIMAKEVDVIE 463
            |..:         :...||..|.:.|.....|...|.  ||.:|....:..|...:........:
Human   385 VALQPSSEAHAMPLGPVTPALPLQCPTANLHKPGGSQQCHPPTPDTGPQNGHPEGVPHTPQRRFQ 449

  Fly   464 QPSAAIETITIEDDDESEEEQQKPEIKK--TPKQNQKPEKQEAPK-KKQIPMPILPAGITISTTS 525
            ..||.|    ::....|..:|..|:..|  .|.:...||.:..|. .:|..:..:|.|:.:.|:.
Human   450 HTSAVI----LQLQPASPPQQCVPDDWKEVAPGEKSVPETRSGPSPHQQAIVTAMPGGLPVPTSP 510

  Fly   526 TAKKKAVRKNSSVTTISSSSSDSSSYSDVEVVPTKKTEKELSMLPGISIIKAESLPLSREDFERS 590
            ..:.....:...  .|..:.:|.||                   ||::.....|
Human   511 NIQPSPAHETGQ--GIVHALTDLSS-------------------PGMTSGNGNS----------- 543

  Fly   591 LRCDEQVPQTPPKSSSSSSSGSHASEMSPPPKLADPKPSSPPAKNAKKANDHDANPSPSSKTNDF 655
                         :||.:.:.....|..||..:..|:..:...:..  .....|.|.|..:::
Human   544 -------------ASSIAGTAPQNGENKPPQAIVKPQILTHVIEGF--VIQEGAEPFPVGRSS-- 591

  Fly   656 KKSMMQNLNMLKWRGQQPANL--QNSTVRFELNEFNFLQINERCQPRQGPAAYFERPLYDRPGRR 718
              .::.||.....:|..|..|  |:.|...:                    :..|.| |.:..:.
Human   592 --LLVGNLKKKYAQGFLPEKLPQQDHTTTTD--------------------SEMEEP-YLQESKE 633

  Fly   719 PSACVHPLLYLCQRCNFHGPAADFL-----APHFCSVGCVR----------------RSQKRRLP 762
            ..|   ||...|:.|.    ..||.     :..|||:.|.:                ||:.::..
Human   634 EGA---PLKLKCELCG----RVDFAYKFKRSKRFCSMACAKRYNVGCTKRVGLFHSDRSKLQKAG 691

  Fly   763 QSTQKESKISRTQL--------EQTAGTAP-------DLPQKRQ--------TNY-KPHKSLSAI 803
            .:|....:.|:..|        :|..||.|       .|...::        ::| :|...:||.
Human   692 AATHNRRRASKASLPPLTKDTKKQPTGTVPLSVTAALQLTHSQEDSSRCSDNSSYEEPLSPISAS 756

  Fly   804 QEQLQQRQKDK--------------------PRKPFRWS-----EYLKSKGKDVAAPIHLFLNPF 843
            ....::||..:                    |.:|.:|:     |:::|
Human   757 SSTSRRRQGQRDLELPDMHMRDLVGMGHHFLPSEPTKWNVEDVYEFIRS---------------- 805

  Fly   844 PISPNCFEIGMKLEA 858
              .|.|.||..:..|
Human   806 --LPGCQEIAEEFRA 818

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(3)mbt	NP_733209.1	MBT	822..918	CDD:214723	7/43 (16%)
		MBT	929..1028	CDD:214723
		MBT	1038..1130	CDD:214723
		SAM_PNT	1279..1366	CDD:280377
PHC2	NP_932157.1	Intrinsically disordered. {ECO:0000250|UniProtKB:Q9QWH1}	1..76		18/84 (21%)
		Interaction with BMI1. {ECO:0000250|UniProtKB:Q9QWH1}	33..53		6/20 (30%)
		COG3416	53..>176	CDD:225950	28/154 (18%)
		HD1	558..587		6/31 (19%)
		PHC2_SAM_assoc	670..788	CDD:293222	16/118 (14%)
		SAM_Ph1,2,3	789..857	CDD:188976	9/49 (18%)
		SAM	791..858	CDD:197735	9/47 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100			O	PTHR12247
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100