DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(3)mbt and phc2a

DIOPT Version :9

Sequence 1:	NP_733209.1	Gene:	l(3)mbt / 43288	FlyBaseID:	FBgn0002441	Length:	1477	Species:	Drosophila melanogaster
Sequence 2:	NP_694490.2	Gene:	phc2a / 171465	ZFINID:	ZDB-GENE-020312-1	Length:	827	Species:	Danio rerio

Alignment Length:	688	Identity:	143/688 - (20%)
Similarity:	236/688 - (34%)	Gaps:	214/688 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 QLQRNISLSMSPANGGVISPSTANCNGVASASGGNPNPNSLLTLAPRKEELRFLPLAPMGGNKTC 77
            |:.|::..:: |.:..:|...||:...:...:   |.| |:.|| |...:::.|.|....|..|.
Zfish   195 QVARSLGRAV-PLSSQLIFTPTASVTAIQPEA---PAP-SINTL-PTSGQVQNLALRSQQGALTS 253

  Fly    78 NITISNVQPMKSKLKSVNIVPNSI-KSAGAGATVGSADAPLFQLVPSP------SNPSQPLVAIL 135
            .::.|.:|.:..|....::...|: :..|.||.            |||      ::|::......
Zfish   254 TLSQSQLQSLSVKQSVASVTGQSVARLKGLGAE------------PSPQGTAAKASPAETSSETT 306

  Fly   136 APNRKTTLLGGG------ASNGQPVVIRSGTPL--------HKNSLTVETSNKPIQPGGS--AAA 184
            |.|.||:.|...      :..|.|.:..:.|.:        ||....::...:.:|.|.:  ..|
Zfish   307 AKNDKTSDLTTSVCPSVTSVAGHPFISTAYTQIQTHQLLQQHKQQFVIQQQPQILQRGQAQLLEA 371

  Fly   185 AAVGGGTGGAPLTLVGKTVVPPKIQAATPVQIPSTGPGAQVSLLANPLKPRAPLILSKVAVDKLR 249
            ||:.           ..||....||:|.|.| |...|        .||.|:.|:...:..:
Zfish   372 AAIH-----------PHTVQAVAIQSALPAQ-PQQCP--------IPLLPKVPVTCQQATI---- 412

  Fly   250 LKFSQVKSNPNALVLGKANHVKKLLTSP-----------NPSGEDKTRSTQKNNKQNTSASQLKP 303
              |.....:..||......|:.....:|           :|....:..::|....::|      |
Zfish   413 --FHSTTVSQQALAQNGQAHILTNTKAPPLQLTAVKCQIHPVQIQQGVASQNVPDKDT------P 469

  Fly   304 VVAPKTAMPIATEVPT----ADNNKMSLIKSK---PVAIKA-VPLPSQEAPIVPAV-------AP 353
            |:.....:.|..:.||    ..::|.|.:|..   .|.:|| |..|       ||:       ||
Zfish   470 VLLEPQLLSIPIQEPTRTELRQSDKESQVKENTQGSVNVKAGVGSP-------PAMTSGSGNNAP 527

  Fly   354 VVT--SPEKVDVKP----TAKPSIKT------------APKPTPKPLEMSVNGPAKEKKAPAKEQ 400
            .||  :|:..:.||    ..||.|.|            .|.|..:|..:..|...|:..|.:..|
Zfish   528 TVTGSAPQNGESKPPPQAVVKPQILTHVIEGFVIQEGAEPFPVERPSLLIENLKQKQHHAYSDLQ 592

  Fly   401 K------------QKTMDKPPVVKEIAQHTPCGPKELP-KLKRSKSFVSNHPASPVANNERRHSV 452
            |            |:..::|..|:....   ||..:.. ..||||.|.|...|       :|::|
Zfish   593 KHNADSEMEDLSLQELNNQPEPVRTCEF---CGNVDFAFNFKRSKRFCSTVCA-------KRYNV 647

  Fly   453 AIMAKEVDVIEQPSAAIETITIEDDDESEEEQQKPEIKKTPK-QNQKPEKQEAPKKKQIPMPILP 516
            . ..|.:.:....|:                   ||..|.|| .::.|:......:|:.|
Zfish   648 G-CTKRMGLFPGKSS-------------------PEDTKKPKASDESPKNCSTETRKRNP----- 687

  Fly   517 AGITISTTSTAKKKAVRKNSSVTTISSSSSDSSSYSDVEVVPTKKTEKELSMLPGISIIKAESLP 581
               :|.||:.|...:...:......||..||.|||           |:.:|             |
Zfish   688 ---SIQTTTGASLLSPHPSHPSHGESSQCSDMSSY-----------EEPIS-------------P 725

  Fly   582 LSREDFERSLRCDEQVPQTPPKSSSSSSSGSHASEMSP 619
            ||...|...:..:|              |..|:.|::|
Zfish   726 LSNSSFGAPIEHEE--------------SFDHSRELTP 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)mbt	NP_733209.1	MBT	822..918	CDD:214723
		MBT	929..1028	CDD:214723
		MBT	1038..1130	CDD:214723
		SAM_PNT	1279..1366	CDD:280377
phc2a	NP_694490.2	Disordered. /evidence=ECO:0000250\|UniProtKB:Q9QWH1	1..78
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	282..316		11/45 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	482..545		19/69 (28%)
		HD1	540..570		7/29 (24%)
		PHC2_SAM_assoc	646..756	CDD:293222	33/170 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	653..730		25/127 (20%)
		SAM_Ph1,2,3	758..826	CDD:188976
		SAM	760..827	CDD:197735
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910