Protein Alignment l(3)mbt and SAMD11

DIOPT Version :10

• Sequence 1: NP_733209.1
• Gene: l(3)mbt / 43288
• FlyBaseID: FBgn0002441
• Length: 1477
• Species: Drosophila melanogaster
• Sequence 2: NP_001372569.1
• Gene: SAMD11 / 148398
• HGNCID: 28706
• Length: 845
• Species: Homo sapiens
• Alignment Length: 1187
• Identity: 207/1187 - (17%)
• Similarity: 341/1187 - (28%)
• Gaps: 485/1187 - (40%)

  Fly   311 MP-IATEVPTADNNKMSLIKSKPVAIKAVPLPSQEAPIVPAVAPVVTSPEKVDVKPTAKPSIKTA 374
            || :..|.|..::..::|....| .:.|:|||    |:...:||:   |....:.|.|
Human     1 MPAVKKEFPGREDLALALATFHP-TLAALPLP----PLPGYLAPL---PAAAALPPAA------- 50

  Fly   375 PKPTPKPLEMSVNGPAKEKKAPAKEQKQKTMDKPPVVKEIAQHTPCGPKELPKLKRSKSFVSNHP 439
                               ..||.....:.:..||                  |:..::::|.|.
Human    51 -------------------SLPASAAGYEALLAPP------------------LRPPRAYLSLHE 78

  Fly   440 ASPVAN-------NERRHSVAIMAKEVD-VIEQPSAAIETITIEDDDESEEEQQKPEIKKTPKQN 496
            |:|..:       .||..:.|..|.:.. :::.....||.       |....:....::|..:.:
Human    79 AAPHLHLPRDPLALERFSATAAAAPDFQPLLDNGEPCIEV-------ECGANRALLYVRKLCQGS 136

  Fly   497 QKPEKQE-----APKKKQIPMPILPAGITISTTSTAK--KKAVR-KNSSVTTISSSSSDSSSYSD 553
            :.|..:.     .|.:.|.          :|...|||  |:::| |..|:.|:.|...
Human   137 KGPSIRHRGEWLTPNEFQF----------VSGRETAKDWKRSIRHKGKSLKTLMSKGI------- 184

  Fly   554 VEVVPTKKTEKELSMLPGISIIKAESLPLSREDFERSLRCDEQVPQTPPKSSSSSSSGSHASEMS 618
            ::|.|      .:...||..|    |.|::|
Human   185 LQVHP------PICDCPGCRI----SSPVNR---------------------------------- 205

  Fly   619 PPPKLADPKP-SSPPAKNAKK-------ANDHDANPS-------PSSKTND------FKKSMMQ- 661
              .:|||.:. :.|.|:|.||       |:|.|::.|       |..|..|      .|:.:..
Human   206 --GRLADKRTVALPAARNLKKERTPSFSASDGDSDGSGPTCGRRPGLKQEDGPHIRIMKRRVHTH 268

  Fly   662 ---NLNMLKWRGQQPANLQNSTVRFELNEFNFLQINE---RCQPRQGPAAYFERPLYD----RPG 716
               |::..:....|..||  .|:...::....|.:.|   ||:.::|......||..|    |.|
Human   269 WDVNISFREASCSQDGNL--PTLISSVHRSRHLVMPEHQSRCEFQRGSLEIGLRPAGDLLGKRLG 331

  Fly   717 RRP---SACVHPLLYLCQRCNFHGPAAD-FLAPHFCSVGCVRRSQKRRLPQSTQKES-------- 769
            |.|   |.|     :..:|.....|.|: .|.|.............|||..:..:.|
Human   332 RSPRISSDC-----FSEKRARSESPQAEALLLPRELGPSMAPEDHYRRLVSALSEASTFEDPQRL 391

  Fly   770 ---------------KISRTQLEQTAGTAPDLP-----QKRQTNYKPHKSLSAIQEQLQQRQKDK 814
                           :::...|...:|....||     |:|:.....|:..:|........:::.
Human   392 YHLGLPSHDLLRVRQEVAAAALRGPSGLEAHLPSSTAGQRRKQGLAQHREGAAPAAAPSFSEREL 456

  Fly   815 PRKPFRWSEYLKSKGKDVAAPIHLFLNPFPISPNCFEIGMKLEAIDPENCSLFCVCSIVEVRGYR 879
            |:.|                         |:             :.|:|.....:       |..
Human   457 PQPP-------------------------PL-------------LSPQNAPHVAL-------GPH 476

  Fly   880 LKLSFDGYSSM------YDFWVNADSQDIFPPGWCDETARVLQAPKDYNSERFSWSRYLVKTGGK 938
            |:..|.|..|.      |.|         .||.               .:|.|:|.:.|::. ..
Human   477 LRPPFLGVPSALCQTPGYGF---------LPPA---------------QAEMFAWQQELLRK-QN 516

  Fly   939 AAPRALFGHLNMQQQMD------VRNGFAVGMHLEAEDLNDTGKICVATVTDILDERIRVHFDGW 997
            .|...|...|..|::::      :....|:..:..||:|...|.:.|..
Human   517 LARLELPADLLRQKELESARPQLLAPETALRPNDGAEELQRRGALLVLN---------------- 565

  Fly   998 DDCYDLWVHITSPYIHPCGWHEGRQQLIVPPDYQKSAFIWDDYISEVGGMAASKELF--TPRQ-- 1058
                                |.....|.:||.....:          |....|::..  .||:
Human   566 --------------------HGAAPLLALPPQGPPGS----------GPPTPSRDSARRAPRKGG 600

  Fly  1059 PMEYQERMKLEVVDQRNPCLIRPATVVTRKGYRVQLHLDCWPTEYYFWLEDDSPDLHPIGWCEAT 1123
            |               .|...||:......|.|:             |.:|.|.|..|   .::.
Human   601 P---------------GPASARPSESKEMTGARL-------------WAQDGSEDEPP---KDSD 634

  Fly  1124 SHELETPPGYLQPKSVMPCDVEGCRGFGNAKRFNLNVHALRECCPYAPENWRQWRSKTVKPPRVA 1188
            ..:.||.             ..||||                                 ..|..|
Human   635 GEDPETA-------------AVGCRG---------------------------------PTPGQA 653

  Fly  1189 PENIRRGWAKKTKRACSEAKQAIKEDSQQEIVYPKVAEVVQAKRKTSPCEEKVVKKQKQMQKEED 1253
            |..          .|.:|.| .:...|...:.:|..         .||...........|    |
Human   654 PAG----------GAGAEGK-GLFPGSTLPLGFPYA---------VSPYFHTGAVGGLSM----D 694

  Fly  1254 AEQVPDERSLAIARSFVKDYGPQFLPNYRLWQLNSAFKLDDVRTNPLHWTSWDVCEYIERALDST 1318
            .|:.|               .|                 :||    ..||..|||.::.......
Human   695 GEEAP---------------AP-----------------EDV----TKWTVDDVCSFVGGLSGCG 723

  Fly  1319 DIAKVIFEQDIDGRALLMLGRKELDTYLKLKVGPAVKLYSLILNL--RIAVVCKFDSKNIELESN 1381
            :..:|..||.|||..|.:|..:.|.|.:.||:|||:|:.:.:...  |:..|..|... :.|:..
Human   724 EYTRVFREQGIDGETLPLLTEEHLLTNMGLKLGPALKIRAQVARRLGRVFYVASFPVA-LPLQPP 787

  Fly  1382 TAGPIQREMDT---PVS 1395
            |....:||:.|   |:|
Human   788 TLRAPERELGTGEQPLS 804

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(3)mbt	NP_733209.1	PRK10819	<332..>427	CDD:236768	15/94 (16%)
		MBT_L3MBTL1-like_rpt1	846..945	CDD:439091	16/104 (15%)
		MBT_L3MBTL1-like_rpt2	957..1045	CDD:439092	10/87 (11%)
		MBT_L3MBTL1-like_rpt3	1058..1130	CDD:439093	12/73 (16%)
		SAM_PNT	1278..1367	CDD:460486	24/90 (27%)
SAMD11	NP_001372569.1	SAND	110..185	CDD:460167	17/98 (17%)
		SAM_Samd7,11	704..771	CDD:188978	22/70 (31%)