DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(3)mbt and Phc1

DIOPT Version :9

Sequence 1:	NP_733209.1	Gene:	l(3)mbt / 43288	FlyBaseID:	FBgn0002441	Length:	1477	Species:	Drosophila melanogaster
Sequence 2:	XP_006505561.1	Gene:	Phc1 / 13619	MGIID:	103248	Length:	1040	Species:	Mus musculus

Alignment Length:	878	Identity:	185/878 - (21%)
Similarity:	296/878 - (33%)	Gaps:	271/878 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ASAEAKQL----QRNISLSMSPANGGVISPSTANCNGVASASGGNPNPNSLLTLAPRKEELRFLP 67
            |||:..|:    |:.|....||.:|  :|.:::....||.||.|....:              |.
Mouse   245 ASAQGPQMPGSTQKAIPPGASPVSG--LSQTSSQALAVAQASSGASGQS--------------LN 293

  Fly    68 LAPMGGNKTCNITISNVQPMKSKLKSVNIVPNSIKSAGAGATVGSADAPLFQLVPSPSNPSQPLV 132
            |:..||.                  |.|.:|.|:...|.|...|.    |.||      ||..|.
Mouse   294 LSQAGGG------------------SGNSLPGSMGPGGGGQAPGG----LGQL------PSSGLT 330

  Fly   133 AILAPNRKTTLLGGGASNGQPVVIRSGTPLHKNSLTVETSNKPIQPGGSAAAAAVGGGTG----G 193
            ....|.:.|.::       ||:.......:.:.|.|...|        :||..|...|:|    |
Mouse   331 GGSCPRKGTGVV-------QPLPAAQTVTVSQGSQTEAES--------AAAKKAEADGSGQQSVG 380

  Fly   194 APLTLVGKTVVPPK----IQAATPVQIPSTGPGAQVSLLANP----LKPRAPLILSKVAVDKLRL 250
            ..||   :|..|..    |.:||..||...      ||:...    |:.:..:|..::|:.. :.
Mouse   381 MNLT---RTATPAPSQTLISSATYTQIQPH------SLIQQQQQIHLQQKQVVIQQQIAIHH-QQ 435

  Fly   251 KFSQVKSNPNALVLGKANHVKKLLTSPNPSGEDKTRSTQKNNKQNTSASQLKPVVAPKTAMPIAT 315
            :|...:|.    :|..|.|::  |.......:.:.:..|:..:|....:.|.....|:  :|...
Mouse   436 QFQHRQSQ----LLHTATHLQ--LAQQQQQQQQQQQQQQQQQQQQQQGTTLTAPQPPQ--VPPTQ 492

  Fly   316 EVPTADNNKMSLIKSKPVAIKAVPLPSQEAPIVPAVAPVV-TSPEKVDVKPTAKPSIKTAPKPTP 379
            :||                    |..||:......|.|:: :||..:..:||:||.|....||..
Mouse   493 QVP--------------------PSQSQQQAQTLVVQPMLQSSPLTLPPEPTSKPPIPIQSKPPV 537

  Fly   380 KPLEMSVNGPAKEKKAPAKEQKQKTMDKPPVVKEIAQHTP---CGPKELPKLKRSKSFVSNHPAS 441
            .|::....|.||         ...|...||       |.|   .|.::              |.|
Mouse   538 APIKPPQLGAAK---------MSATQQPPP-------HIPVQVVGTRQ--------------PGS 572

  Fly   442 PVANNERRHSVAIMAKEVDVIEQPSAAIET---ITIEDDDESEEEQQKPEIKKTPKQNQKPEKQE 503
            ..|             :...:.|.:||:.|   ||      ...:..:..:..:|     |..|.
Mouse   573 AQA-------------QALGLAQLAAAVPTPRGIT------GAVQPGQAHLASSP-----PSSQA 613

  Fly   504 APKKKQIPMPILPAGITIS----TTSTAKKKAVRKNSSVTTISSSSSDSSSYSDVEVVPTKKTEK 564
            ||...|...|.|.||:|::    |....|......:..|..:.::....|.:
Mouse   614 APGALQECPPALAAGMTLAPVQGTAHVVKGGPTASSPVVAQVPAAFYMQSVH------------- 665

  Fly   565 ELSMLPGISIIKAESLPLSREDFERSLRCD------------EQVPQTPPKSSSSSSSGSHASEM 617
                |||    ||::|.:.|:......|.|            ....::|......:|.|..|..:
Mouse   666 ----LPG----KAQTLAVKRKAESEEERDDLSALASVLPTKASPAAESPKVIEEKNSLGEKAEPV 722

  Fly   618 SP----PPK-----LADPKPSSPPAKNAKKAND-HDANP-----SPSSKTNDFKKSMMQNLNMLK 667
            :.    ||.     || |.||:||...|..:.. .|:.|     .|...|:..:..::|
Mouse   723 ASLNANPPNSDLVALA-PTPSAPPPTLALVSRQMGDSKPPQAIVKPQILTHIIEGFVIQ------ 780

  Fly   668 WRGQQPANLQNSTVRFELNEFNFLQINERCQPRQG--PAAYFE-RPLYDRPGRRPSACVHPL--L 727
             .|.:|         |.:....||:  |..:|.|.  |....| :|.....|..||..:...  |
Mouse   781 -EGAEP---------FPVGCSQFLK--ETKKPLQAGLPTGLNESQPSGPLGGDSPSVELEKKANL 833

  Fly   728 YLCQRCNFHGPAADFL-APHFCSVGCVRR-----SQKRRLPQSTQK---ESKISRTQLEQTAGTA 783
            ..|:.|..:.||..|. :..|||:.|.:|     |.:.||.:...|   |:..:|.:......::
Mouse   834 LKCEYCGKYAPAEQFRGSKRFCSMTCAKRYNVSCSHQFRLKRKKMKEFQEASYARVRRRGPRRSS 898

  Fly   784 PDLPQKRQTNYKPHKSLSAIQEQLQQRQKDKPR 816
            .|:.:.:            ||.:..:.|:|..|
Mouse   899 SDIARAK------------IQGKRHRGQEDSSR 919

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)mbt	NP_733209.1	MBT	822..918	CDD:214723
		MBT	929..1028	CDD:214723
		MBT	1038..1130	CDD:214723
		SAM_PNT	1279..1366	CDD:280377
Phc1	XP_006505561.1	PHA03247	<509..639	CDD:223021	41/183 (22%)
		PHC2_SAM_assoc	864..970	CDD:374673	12/68 (18%)
		SAM_Ph1,2,3	971..1039	CDD:188976
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839861
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840