Protein Alignment l(3)mbt and Phc1

DIOPT Version :10

• Sequence 1: NP_733209.1
• Gene: l(3)mbt / 43288
• FlyBaseID: FBgn0002441
• Length: 1477
• Species: Drosophila melanogaster
• Sequence 2: XP_006505561.1
• Gene: Phc1 / 13619
• MGIID: 103248
• Length: 1040
• Species: Mus musculus
• Alignment Length: 878
• Identity: 185/878 - (21%)
• Similarity: 296/878 - (33%)
• Gaps: 271/878 - (30%)

  Fly     7 ASAEAKQL----QRNISLSMSPANGGVISPSTANCNGVASASGGNPNPNSLLTLAPRKEELRFLP 67
            |||:..|:    |:.|....||.:|  :|.:::....||.||.|....:              |.
Mouse   245 ASAQGPQMPGSTQKAIPPGASPVSG--LSQTSSQALAVAQASSGASGQS--------------LN 293

  Fly    68 LAPMGGNKTCNITISNVQPMKSKLKSVNIVPNSIKSAGAGATVGSADAPLFQLVPSPSNPSQPLV 132
            |:..||.                  |.|.:|.|:...|.|...|.    |.||      ||..|.
Mouse   294 LSQAGGG------------------SGNSLPGSMGPGGGGQAPGG----LGQL------PSSGLT 330

  Fly   133 AILAPNRKTTLLGGGASNGQPVVIRSGTPLHKNSLTVETSNKPIQPGGSAAAAAVGGGTG----G 193
            ....|.:.|.::       ||:.......:.:.|.|...|        :||..|...|:|    |
Mouse   331 GGSCPRKGTGVV-------QPLPAAQTVTVSQGSQTEAES--------AAAKKAEADGSGQQSVG 380

  Fly   194 APLTLVGKTVVPPK----IQAATPVQIPSTGPGAQVSLLANP----LKPRAPLILSKVAVDKLRL 250
            ..||   :|..|..    |.:||..||...      ||:...    |:.:..:|..::|:.. :.
Mouse   381 MNLT---RTATPAPSQTLISSATYTQIQPH------SLIQQQQQIHLQQKQVVIQQQIAIHH-QQ 435

  Fly   251 KFSQVKSNPNALVLGKANHVKKLLTSPNPSGEDKTRSTQKNNKQNTSASQLKPVVAPKTAMPIAT 315
            :|...:|.    :|..|.|::  |.......:.:.:..|:..:|....:.|.....|:  :|...
Mouse   436 QFQHRQSQ----LLHTATHLQ--LAQQQQQQQQQQQQQQQQQQQQQQGTTLTAPQPPQ--VPPTQ 492

  Fly   316 EVPTADNNKMSLIKSKPVAIKAVPLPSQEAPIVPAVAPVV-TSPEKVDVKPTAKPSIKTAPKPTP 379
            :||                    |..||:......|.|:: :||..:..:||:||.|....||..
Mouse   493 QVP--------------------PSQSQQQAQTLVVQPMLQSSPLTLPPEPTSKPPIPIQSKPPV 537

  Fly   380 KPLEMSVNGPAKEKKAPAKEQKQKTMDKPPVVKEIAQHTP---CGPKELPKLKRSKSFVSNHPAS 441
            .|::....|.||         ...|...||       |.|   .|.::              |.|
Mouse   538 APIKPPQLGAAK---------MSATQQPPP-------HIPVQVVGTRQ--------------PGS 572

  Fly   442 PVANNERRHSVAIMAKEVDVIEQPSAAIET---ITIEDDDESEEEQQKPEIKKTPKQNQKPEKQE 503
            ..|             :...:.|.:||:.|   ||      ...:..:..:..:|     |..|.
Mouse   573 AQA-------------QALGLAQLAAAVPTPRGIT------GAVQPGQAHLASSP-----PSSQA 613

  Fly   504 APKKKQIPMPILPAGITIS----TTSTAKKKAVRKNSSVTTISSSSSDSSSYSDVEVVPTKKTEK 564
            ||...|...|.|.||:|::    |....|......:..|..:.::....|.:
Mouse   614 APGALQECPPALAAGMTLAPVQGTAHVVKGGPTASSPVVAQVPAAFYMQSVH------------- 665

  Fly   565 ELSMLPGISIIKAESLPLSREDFERSLRCD------------EQVPQTPPKSSSSSSSGSHASEM 617
                |||    ||::|.:.|:......|.|            ....::|......:|.|..|..:
Mouse   666 ----LPG----KAQTLAVKRKAESEEERDDLSALASVLPTKASPAAESPKVIEEKNSLGEKAEPV 722

  Fly   618 SP----PPK-----LADPKPSSPPAKNAKKAND-HDANP-----SPSSKTNDFKKSMMQNLNMLK 667
            :.    ||.     || |.||:||...|..:.. .|:.|     .|...|:..:..::|
Mouse   723 ASLNANPPNSDLVALA-PTPSAPPPTLALVSRQMGDSKPPQAIVKPQILTHIIEGFVIQ------ 780

  Fly   668 WRGQQPANLQNSTVRFELNEFNFLQINERCQPRQG--PAAYFE-RPLYDRPGRRPSACVHPL--L 727
             .|.:|         |.:....||:  |..:|.|.  |....| :|.....|..||..:...  |
Mouse   781 -EGAEP---------FPVGCSQFLK--ETKKPLQAGLPTGLNESQPSGPLGGDSPSVELEKKANL 833

  Fly   728 YLCQRCNFHGPAADFL-APHFCSVGCVRR-----SQKRRLPQSTQK---ESKISRTQLEQTAGTA 783
            ..|:.|..:.||..|. :..|||:.|.:|     |.:.||.:...|   |:..:|.:......::
Mouse   834 LKCEYCGKYAPAEQFRGSKRFCSMTCAKRYNVSCSHQFRLKRKKMKEFQEASYARVRRRGPRRSS 898

  Fly   784 PDLPQKRQTNYKPHKSLSAIQEQLQQRQKDKPR 816
            .|:.:.:            ||.:..:.|:|..|
Mouse   899 SDIARAK------------IQGKRHRGQEDSSR 919

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(3)mbt	NP_733209.1	PRK10819	<332..>427	CDD:236768	24/98 (24%)
		MBT_L3MBTL1-like_rpt1	846..945	CDD:439091
		MBT_L3MBTL1-like_rpt2	957..1045	CDD:439092
		MBT_L3MBTL1-like_rpt3	1058..1130	CDD:439093
		SAM_PNT	1278..1367	CDD:460486
Phc1	XP_006505561.1	PHA03247	<509..639	CDD:223021	41/183 (22%)
		PHC2_SAM_assoc	864..971	CDD:465202	12/68 (18%)
		SAM_Ph1,2,3	971..1039	CDD:188976