DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(3)mbt and SCML2

DIOPT Version :9

Sequence 1:	NP_733209.1	Gene:	l(3)mbt / 43288	FlyBaseID:	FBgn0002441	Length:	1477	Species:	Drosophila melanogaster
Sequence 2:	NP_006080.1	Gene:	SCML2 / 10389	HGNCID:	10581	Length:	700	Species:	Homo sapiens

Alignment Length:	750	Identity:	185/750 - (24%)
Similarity:	271/750 - (36%)	Gaps:	240/750 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   788 QKRQTNYKPHKSLSAIQEQLQQRQKDKPRKPFRWSEYLKSKGKDVAAPIHLFLNPFPISP-NCFE 851
            :|......|..|.|::|           |..|.|.||||..| .::||...| ....|.| |.|:
Human    13 KKENQEKTPQSSTSSVQ-----------RDDFHWEEYLKETG-SISAPSECF-RQSQIPPVNDFK 64

  Fly   852 IGMKLEAIDPENCSLFCVCSIVEVRGYRLKLSFDGYSSMYDFWVNADSQDIFPPGWCDETARVLQ 916
            :||||||.||.|.:..|:.:::.:.|.||:|..||..:..|||...||.||.|.|.|::...:||
Human    65 VGMKLEARDPRNATSVCIATVIGITGARLRLRLDGSDNRNDFWRLVDSPDIQPVGTCEKEGDLLQ 129

  Fly   917 APKDYNSERFSWSRYLVKT--GGKAAPRALFGHLNMQQQMDVRNGFAVGMHLEAEDLNDTGKICV 979
            .|..|.....||..:|:||  |.:.|...||   ..:......|.|.|||.|||.|..:...||.
Human   130 PPLGYQMNTSSWPMFLLKTLNGSEMASATLF---KKEPPKPPLNNFKVGMKLEAIDKKNPYLICP 191

  Fly   980 ATVTDILDERIRVHFDGWDDCYDLWVHITSPYIHPCGWHEGRQQLIVPP---------------- 1028
            ||:.|:..:.:.:.||||...:|.|....|..|.|.||......::.||
Human   192 ATIGDVKGDEVHITFDGWSGAFDYWCKYDSRDIFPAGWCRLTGDVLQPPGTSVPIVKNIAKTESS 256

  Fly  1029 ----------DYQKSAFIW-------DDYISEVGGMAASK-----ELFTPRQ--PMEYQERMKLE 1069
                      ..||:..|.       ...|...|..|..|     :..|||:  |...::...|.
Human   257 PSEASQHSMQSPQKTTLILPTQQVRRSSRIKPPGPTAVPKRSSSVKNITPRKKGPNSGKKEKPLP 321

  Fly  1070 VVDQRN---------------------PCLIRPATV---VTRKGYRVQLHLDCWPTEYYFWLEDD 1110
            |:...:                     ||.|..:||   |.:.| ....|||  |...     ..
Human   322 VICSTSAASLKSLTRDRGMLYKDVASGPCKIVMSTVCVYVNKHG-NFGPHLD--PKRI-----QQ 378

  Fly  1111 SPDLH----PIG--------WCEATSHELETPPGYLQPKS----VMPCDVEG---------CRGF 1150
            .|| |    |:.        .|...:.|.:|..|||:|.:    |:....:|         ....
Human   379 LPD-HFGPGPVNVVLRRIVQACVDCALETKTVFGYLKPDNRGGEVITASFDGETHSIQLPPVNSA 442

  Fly  1151 GNAKRFNLN-VHALRECC-------PY------------------APENWRQWRSKTVKP----P 1185
            ..|.||..| .|:|:  |       |:                  |.|:..:.:|....|    |
Human   443 SFALRFLENFCHSLQ--CDNLLSSQPFSSSRGHTHSSAEHDKNQSAKEDVTERQSTKRSPQQTVP 505

  Fly  1186 RVAPENIRRGWAKKTKRACSEA------------KQAIKEDSQQE----------------IVYP 1222
            .|.|.:.:   ..|||...||.            ::.:.|||:..                .::.
Human   506 YVVPLSPK---LPKTKEYASEGEPLFAGGSAIPKEENLSEDSKSSSLNSGNYLNPACRNPMYIHT 567

  Fly  1223 KVAE--------------VVQAKRKTSPCEEKVVKKQKQMQKEEDAEQ---VPDERSLAIARSFV 1270
            .|::              |.....|:||.|.|.     |||::.:|..   |||..  .:.:.|.
Human   568 SVSQDFSRSVPGTTSSPLVGDISPKSSPHEVKF-----QMQRKSEAPSYIAVPDPS--VLKQGFS 625

  Fly  1271 KDYGPQFLPNYRLWQLNSAFKLDDVRTNPLHWTSWDVCEYIERALDSTD------IAKVIFEQDI 1329
            ||                          |..|:..:|.::::.    ||      :|.:..:.:|
Human   626 KD--------------------------PSTWSVDEVIQFMKH----TDPQISGPLADLFRQHEI 660

  Fly  1330 DGRALLMLGRKELDTYLKLKVGPAVKLYSLILNLR 1364
            ||:||.:|....:..|:.||:|||:||...|..|:
Human   661 DGKALFLLKSDVMMKYMGLKLGPALKLCYYIEKLK 695

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)mbt	NP_733209.1	MBT	822..918	CDD:214723	40/96 (42%)
		MBT	929..1028	CDD:214723	32/100 (32%)
		MBT	1038..1130	CDD:214723	27/134 (20%)
		SAM_PNT	1279..1366	CDD:280377	22/91 (24%)
SCML2	NP_006080.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33		6/30 (20%)
		MBT 1	33..131		42/99 (42%)
		MBT	36..131	CDD:214723	40/96 (42%)
		MBT 2	139..240		34/103 (33%)
		MBT	142..240	CDD:214723	32/100 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	253..320		11/66 (17%)
		DUF3588	356..465	CDD:288954	28/119 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	466..550		16/86 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	575..594		2/18 (11%)
		SAM_Scm	625..696	CDD:188977	24/100 (24%)
		SAM	628..696	CDD:197735	22/71 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149816
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840