DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(3)mbt and sfmbt1

DIOPT Version :9

Sequence 1:	NP_733209.1	Gene:	l(3)mbt / 43288	FlyBaseID:	FBgn0002441	Length:	1477	Species:	Drosophila melanogaster
Sequence 2:	XP_005155896.2	Gene:	sfmbt1 / 100001629	ZFINID:	ZDB-GENE-030131-2592	Length:	868	Species:	Danio rerio

Alignment Length:	910	Identity:	170/910 - (18%)
Similarity:	281/910 - (30%)	Gaps:	378/910 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   799 SLSAIQEQLQQRQKDKPRKPFRWSEYLKSKGKDVAAPIHLF----------LNPFPISPNCFEIG 853
            ||.|::......|   ....|.|.:||:..|. ::.|.|.|          |.|          |
Zfish     2 SLEALESDADSGQ---DVSEFNWDDYLEESGA-LSVPHHAFKHVDQGLETGLTP----------G 52

  Fly   854 MKLE-AIDPENCSLFCVCSIVEVRGYRLKLSFDGYSS--MYDFWVNADSQDIFPPGWCDETARVL 915
            |||| .:..|:.|::.|.:|:...|..|.|.::||..  ..|||.:..:.|:.|.||..:..|::
Zfish    53 MKLEVCVRTESESVYWVATIITTCGQLLLLRYEGYQDDRRADFWCDIMTADLHPIGWSKQQGRMM 117

  Fly   916 QAPKDYNSERFSWSRYLVKTGGK--AAPRALFGHLNMQQQMDVRNGFAVGMHLEAEDLNDTGKIC 978
            :.|:....:...|...|.|...:  :.|.:|..  ..|:..:..:..:.|:::|..|..|.|.:.
Zfish   118 KPPEGVREKHQDWEALLEKALAESCSVPASLLE--GAQRGCNPIDLLSPGLNVELVDHQDAGVVW 180

  Fly   979 VATVTDILDERIRVHFDGWDDCYD----LWVHITSPYIHPCGW---------------------- 1017
            .|.:.:.:..|:|:.:.|.|...:    .||....|.:|..||
Zfish   181 SAVIEENIGGRLRLRYAGTDGLPENQSITWVFYLDPLLHLSGWAQEHNCTLRPPAALLPLRTEAE 245

  Fly  1018 ------------------------------H---EGRQ--------------------------- 1022
                                          |   ||.:
Zfish   246 WEEVKKSISSQEQDPSISEEFYRDRSAITPHCFTEGMKLEAVDPAAPFTISPATVAKVFNEQFFL 310

  Fly  1023 ---------------------------------------QLIVPPDYQKSAFIWDDYISEVGGMA 1048
                                                   :|..||.:|...|.|.||:.:....|
Zfish   311 VLMDDMRDEAQKEGGAHSFLCHRDSPGIFPTQWSLKNGVKLSPPPGFQGQDFDWADYLKQCEAEA 375

  Fly  1049 ASKELFTPRQPME--YQERMKLEVVDQRNPCLIRPATVVTRKGYRVQLHLD----CWPTEYYFWL 1107
            |.::.|.| .|.:  .:|.|.||.|:...|..|..|||...||..:.:.|:    ..|.   ..:
Zfish   376 APQQCFPP-DPSDQCIKESMMLEAVNPICPENIHVATVTKVKGQHMWIRLEGLKQAMPE---IIV 436

  Fly  1108 EDDSPDLHPIGWCEATSHELETP----------PGYLQP-------KSVMP-------------- 1141
            ..||.|:.|:.|||...:.|..|          ...:||       |...|
Zfish   437 HTDSMDIFPVSWCETNGYPLLHPCKPRVEKQRKVAVVQPEKHRVPSKDSSPDTTKQHMNSSQAEM 501

  Fly  1142 ------------------------------CDVEGCRGFGN------------------------ 1152
                                          .::..|.|.||
Zfish   502 AGQANGKYCCPKIYFNHRCFSGPYLNKGRIAELPQCVGPGNCVLVLKEVLTLLINSAYKPSRVLR 566

  Fly  1153 ----------------------AKRFNLNVHALR----------------ECCP--YAP------ 1171
                                  .|.:...|..:|                ||||  :.|
Zfish   567 ELQLDQEGRWQGHGETLKAKYKGKSYRATVEIVRTADQVADFCRKTCIKLECCPNLFGPRMVLER 631

  Fly  1172 --EN------------WRQWRSKTVKPPRVAPENI-----RRGWAKK--------TKRACS---- 1205
              ||            :.:.:|:.|..|.....|:     |||..:|        .||..|
Zfish   632 CSENCSVLTKTKYTYYYGKKKSRRVGRPPGGHSNLEGGVKRRGRRRKRRKQLFVHKKRRSSASVD 696

  Fly  1206 ----------------EAKQAIKEDSQQEIVYPKVAEVVQAKRKT-----SPCEEKVVKKQKQMQ 1249
                            :...::.||:..|:....:.:...:::|:     ||...:..:..::.:
Zfish   697 NTPAGSPQGSGDEEDLDEDDSLSEDTGSEMQDELMDDSEYSEKKSQPPTPSPSPPETPRPTRRRR 761

  Fly  1250 K------EEDAEQVPDERSLAIARSFVKDYGPQFLPNYRLWQLNSAFKLDDVRTNPLHWTSWDVC 1308
            |      .:|..:.|..:|   .|:.|    ||.|               .:.::||.|:..||.
Zfish   762 KARSPSCSDDENRPPSPKS---PRTEV----PQKL---------------CLESSPLEWSVTDVV 804

  Fly  1309 EYIERALDSTDIAKVIFEQDIDGRALLMLGRKELDTYLKLKVGPAVKLYSLILNLRIAVVCKFDS 1373
            .:| |..|...:|::..:|:|||:|||:|....:...:.||:|||:||...|..:::|...:|.|
Zfish   805 RFI-RTTDCAPLARIFMDQEIDGQALLLLNLPTVQECMDLKLGPAIKLCHHIERVKLAFYQQFAS 868

Fly 1374 1373
Zfish 869 868

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)mbt	NP_733209.1	MBT	822..918	CDD:214723	30/108 (28%)
		MBT	929..1028	CDD:214723	25/225 (11%)
		MBT	1038..1130	CDD:214723	29/97 (30%)
		SAM_PNT	1279..1366	CDD:280377	25/86 (29%)
sfmbt1	XP_005155896.2	MBT	22..120	CDD:214723	30/108 (28%)
		MBT	153..234	CDD:327428	17/80 (21%)
		MBT	255..354	CDD:214723	4/98 (4%)
		MBT	366..456	CDD:214723	28/93 (30%)
		SLED	511..626	CDD:314933	11/114 (10%)
		SAM_Scm-like-4MBT1,2	784..868	CDD:188980	31/103 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583965
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840