Protein Alignment PolA2 and POL12

DIOPT Version :10

• Sequence 1: NP_733206.3
• Gene: PolA2 / 43278
• FlyBaseID: FBgn0005696
• Length: 609
• Species: Drosophila melanogaster
• Sequence 2: NP_009518.1
• Gene: POL12 / 852245
• SGDID: S000000131
• Length: 705
• Species: Saccharomyces cerevisiae
• Alignment Length: 687
• Identity: 158/687 - (22%)
• Similarity: 268/687 - (39%)
• Gaps: 198/687 - (28%)

  Fly    42 QWMAFSLSHLQGE-DPAIENLGDFERKVLQLRKDKAGYK-------------------------- 79
            :|..||....|.. |...:|:.:| ::.|||:.:|...:
Yeast    41 KWEQFSNQRRQTHTDLTSKNIDEF-KQFLQLQMEKRANQISSSSKVNTSTKKPVIKKSLNSSPLF 104

  Fly    80 -------ATGQKAKSYGSPSVQDTSSLATYGV---------------MEDDP-MLDDYVSESAVD 121
                   .|.:|.|.:|..|:.|  |..||.|               :|..| |.:|.|.:||..
Yeast   105 GLSIPKTPTLKKRKLHGPFSLSD--SKQTYNVGSEAETNEKGNSSLKLEFTPGMAEDAVGDSAPL 167

  Fly   122 SSALHTPKAKKQSDRTANLKGAALF-SPASYTPQSAKRKAGLETPSNSVAG--KPGDIVDTFGHP 183
            |.|       |.||  |...|::.| :|.:.||.::::    ..|:..:..  .|.:|..:.|:|
Yeast   168 SHA-------KSSD--AKTPGSSTFQTPTTNTPTTSRQ----NVPAGEILDSLNPENIEISSGNP 219

  Fly   184 K--LLAGSSWQSQMEHTVPVTQKLLHNDA---PLTIA----------NLGYMNDLLTDRCHNL-R 232
            .  ||:              |::..:|..   |...|          ||...:|:|.|:..:. :
Yeast   220 NVGLLS--------------TEEPSYNQVKVEPFYDAKKYKFRTMRQNLQEASDVLDDQIESFTK 270

  Fly   233 VRFNQTGPALVDKKLGQAGAAECIWYPQDRQVLQSAGGLHAVGMIHSEDDGPLDAHSAFM----A 293
            :..|.       .||.....|:        ..:||...::|||.|  ..|.|  .:..|:    .
Yeast   271 IIQNH-------YKLSPNDFAD--------PTIQSQSEIYAVGRI--VPDSP--TYDKFLNPESL 316

  Fly   294 VLDDDVEDEMDPTLTLNFSRVKSASIFPGQVVLAKGFIPRGKTFMVEEIHTERKLT---PATPLQ 355
            .|:......:...:.|:.|:|...|.|.||:|..||....|..|.|..|     |.   |.:|:.
Yeast   317 SLETSRMGGVGRRVRLDLSQVNELSFFLGQIVAFKGKNANGDYFTVNSI-----LPLPYPNSPVS 376

  Fly   356 IDRELQ------------FVVASGPFTDSTDLFYEPLHDLLKYLKDH-RPDVLVLTGPFLDADHK 407
            ..:|||            .:|..||:..:.:...|.|.:.:..:.:. :|.||::.|||:|..|.
Yeast   377 TSQELQEFQANLEGSSLKVIVTCGPYFANDNFSLELLQEFIDSINNEVKPHVLIMFGPFIDITHP 441

  Fly   408 MV--GEL---------AETFDTFFEKMIGGIMESIGSHTAVLVVTSQKDAMA-LSVYPTPP---P 457
            ::  |:|         .:|.|..|.|:...|:::|..|...:::.|.|||:: .:.||...   .
Yeast   442 LIASGKLPNFPQFKTQPKTLDELFLKLFTPILKTISPHIQTVLIPSTKDAISNHAAYPQASLIRK 506

  Fly   458 ALRRTYPNLYMLPDPSLVDLDGFTLGVTSTDVVDHLLSHEFAVNAGE-----RMHRAINHLFHQG 517
            ||:....|...:.:||...::....|.::.|....|   :..:..|.     |:.|...|:..|.
Yeast   507 ALQLPKRNFKCMANPSSFQINEIYFGCSNVDTFKDL---KEVIKGGTTSSRYRLDRVSEHILQQR 568

  Fly   518 SFYPLYP--------PAD-------------EDMAYD----SQLALKYAQLKQL-----PNVLIL 552
            .:||::|        |.|             |:..|:    :.|.:.|..|.:.     |:::|:
Yeast   569 RYYPIFPGSIRTRIKPKDVSTKKETNDMESKEEKVYEHISGADLDVSYLGLTEFVGGFSPDIMII 633

  Fly   553 PSDQRHFIRLVNDCLVINPGRVADKKG--GTFARFLV 587
            ||:.:||.|:|.:.:||||||.....|  |::|:..|
Yeast   634 PSELQHFARVVQNVVVINPGRFIRATGNRGSYAQITV 670

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolA2	NP_733206.3	DNA_pol_E_B	362..561	CDD:461142	57/249 (23%)
POL12	NP_009518.1	POL12	9..705	CDD:227539	158/687 (23%)