Protein Alignment: DNApol-alpha73 and pola2

• Sequence 1: NP_733206.3
• Gene: DNApol-alpha73
• FlyBaseID: FBgn0005696
• Length: 609
• Species: Drosophila melanogaster
• Sequence 2: XP_012816322.1
• Gene: pola2
• XenbaseID: XB-GENE-5916783
• Length: 642
• Species: Xenopus tropicalis
• Alignment Length: 650
• Identity: 185/650 (28%)
• Similarity: 302/650 (46%)
• Gaps: 101/650 (16%)

  Fly     1 MEEEL---KQQFDEMGVEPADAVLGRCAELAITYNIHDATEFVEQWMAFSLSHLQGEDPAIENLG 62
            :||||   ...|::      |.|..:..||...:.:.: .:.|.:|||||.:  :.....:.||.
 Frog    53 IEEELTVFDVNFED------DEVPEKMVELCTVHRLQE-EDMVNEWMAFSTT--RNLPLTVSNLN 108

  Fly    63 DFERKVLQLRKDKAGYKATGQKAKSYGS---PSVQDTSSLATYGVMEDDPMLDDYVSES-AVDSS 123
            ..|.:|  |.|..|..:.:.:|.|..|:   .::|:...:.|    |::.:||.|.:.: .....
 Frog   109 ILEHEV--LNKKSARPRPSQKKEKHCGNRDFNTIQELIEVET----EEENLLDSYATPAKGSQKR 167

  Fly   124 ALHTPKAKKQSDRTANLKGAALFSPASYTPQSAKRKAGLETPSNSVAGKP--GDIVDTFGHPKLL 186
            .|.||:..:....:.|.....||||||::|.:        |||.....:.  |::|.|:|.   |
 Frog   168 NLSTPEHPQSKRISVNRSPHVLFSPASFSPSA--------TPSQKYGSRTNRGEVVTTYGE---L 221

  Fly   187 AGSSWQSQMEHTVPVTQKLLHNDAPLTIANLGYMNDLLTDRCHNLRVRFNQTGPALVDKKLGQAG 251
            .|::|.........| :.....|.|||     .|...:..:..::|        .:|..|:.:.|
 Frog   222 QGTTWNGGSGRNTSV-ELFTCQDEPLT-----KMYKFMFQKLMDIR--------EVVSSKIEELG 272

  Fly   252 AA----------ECIWYPQDRQVLQSAGGLHAVGMIHSEDDGPLDAHSAFMAVLDDDVEDEMDPT 306
            |:          ..:.:|....|.       .:|.|..:.:|.|::.|   .:|:.|.|......
 Frog   273 ASLKNHFQIDEFTSVSFPAQETVT-------VLGQIGCDSNGKLNSKS---VILEGDREHSAGMQ 327

  Fly   307 LTLNFSRVKSASIFPGQVVLAKGFIPRGKTFMVEEIHTERKLTPATPL---QIDRELQ------F 362
            :.::.|.:|..|:||||||:.:|....|:.|:      ..||....||   |..:|.:      .
 Frog   328 VPVDLSELKEYSLFPGQVVIMEGTNSTGRRFV------PTKLYEGVPLPFHQPSKEFEECPQQMV 386

  Fly   363 VVASGPFTDSTDLFYEPLHDLLKYLKDHRPDVLVLTGPFLDADHKMVG--ELAETFDTFFEKMIG 425
            :.|.||||.|..:.|:.|.||:..|....||:.:|.||||||.|:.:.  :|..||:..|::.:.
 Frog   387 ITACGPFTTSDTITYDALKDLIDVLNRDCPDICILLGPFLDAKHEQIENLQLTVTFEDVFKRCLK 451

  Fly   426 GIMESI---GSHTAVLVVTSQKDAMALSVYPTPP-----PALRRTYPNLYMLPDPSLVDLDGFTL 482
            .|:|..   |.|  ::.|.|.:|.....|||.||     || :.....::.:.||..:.::|..|
 Frog   452 MIIEGTRLSGCH--LVFVPSLRDVHHDPVYPQPPFSCFEPA-KEDKDRVHFVADPCTLSVNGVIL 513

  Fly   483 GVTSTDVVDHLLSHEF--AVNAGERMHRAINHLFHQGSFYPLYPPADEDMAYDSQLALKYAQLKQ 545
            |:||||::.|:.:.|.  :|.|.:|..|.:.|:..|.|:|||||| :|::..|.:....||.:..
 Frog   514 GITSTDLLFHMGAEEISSSVGAPDRFSRILRHILTQRSYYPLYPP-NEEINVDYEAFYSYAPMPV 577

  Fly   546 LPNVLILPSDQRHFIRLVNDCLVINPGRVA-DKKGGTFARFLVAPSVPGKAANMFNSVACQVQRI 609
            .|::.|:||:.|:||:.|..|:.|||||:. ...|||:|||||.....|........::.||.||
 Frog   578 TPDIFIVPSELRYFIKDVTGCICINPGRLTKGLVGGTYARFLVKSGAMGSEGKRSPCISAQVVRI 642

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-alpha73	NP_733206.3	Pol_alpha_B_N	18..>180	CDD:285602	43/168 (26%)
		DNA_pol_E_B	363..561	CDD:281968	74/210 (35%)
pola2	XP_012816322.1	POL12	65..630	CDD:227539	176/625 (28%)
		Pol_alpha_B_N	66..291	CDD:285602	59/265 (22%)
		DNA_pol_E_B	389..593	CDD:281968	74/208 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930				C238492068
eggNOG	1	0.900				E1_COG5214
Hieranoid	1	1.000
Homologene	1	1.000				H48121
Inparanoid	1	1.050	216	1.000	Inparanoid score	I3401
OMA	1	1.010
OrthoDB	1	1.010				D239034at33208
OrthoFinder	1	1.000				FOG0004201
OrthoInspector	1	1.000				T1059836
Phylome	1	0.910		0.667	Consistency score
RoundUp	1	1.030		avgDist	Average_Evolutionary_Distance	R342
TreeFam	1	0.960
	12	11.800