Protein Alignment PolA2 and pola2

DIOPT Version :10

• Sequence 1: NP_733206.3
• Gene: PolA2 / 43278
• FlyBaseID: FBgn0005696
• Length: 609
• Species: Drosophila melanogaster
• Sequence 2: NP_001005060.1
• Gene: pola2 / 448613
• XenbaseID: XB-GENE-5916783
• Length: 597
• Species: Xenopus tropicalis
• Alignment Length: 650
• Identity: 185/650 - (28%)
• Similarity: 302/650 - (46%)
• Gaps: 101/650 - (15%)

  Fly     1 MEEEL---KQQFDEMGVEPADAVLGRCAELAITYNIHDATEFVEQWMAFSLSHLQGEDPAIENLG 62
            :||||   ...|::      |.|..:..||...:.:.: .:.|.:|||||.:  :.....:.||.
 Frog     8 IEEELTVFDVNFED------DEVPEKMVELCTVHRLQE-EDMVNEWMAFSTT--RNLPLTVSNLN 63

  Fly    63 DFERKVLQLRKDKAGYKATGQKAKSYGS---PSVQDTSSLATYGVMEDDPMLDDYVSES-AVDSS 123
            ..|.:|  |.|..|..:.:.:|.|..|:   .::|:...:.|    |::.:||.|.:.: .....
 Frog    64 ILEHEV--LNKKSARPRPSQKKEKHCGNRDFNTIQELIEVET----EEENLLDSYATPAKGSQKR 122

  Fly   124 ALHTPKAKKQSDRTANLKGAALFSPASYTPQSAKRKAGLETPSNSVAGKP--GDIVDTFGHPKLL 186
            .|.||:..:....:.|.....||||||::|.:        |||.....:.  |::|.|:|.   |
 Frog   123 NLSTPEHPQSKRISVNRSPHVLFSPASFSPSA--------TPSQKYGSRTNRGEVVTTYGE---L 176

  Fly   187 AGSSWQSQMEHTVPVTQKLLHNDAPLTIANLGYMNDLLTDRCHNLRVRFNQTGPALVDKKLGQAG 251
            .|::|.........| :.....|.|||     .|...:..:..::|        .:|..|:.:.|
 Frog   177 QGTTWNGGSGRNTSV-ELFTCQDEPLT-----KMYKFMFQKLMDIR--------EVVSSKIEELG 227

  Fly   252 AA----------ECIWYPQDRQVLQSAGGLHAVGMIHSEDDGPLDAHSAFMAVLDDDVEDEMDPT 306
            |:          ..:.:|....|.       .:|.|..:.:|.|::.|   .:|:.|.|......
 Frog   228 ASLKNHFQIDEFTSVSFPAQETVT-------VLGQIGCDSNGKLNSKS---VILEGDREHSAGMQ 282

  Fly   307 LTLNFSRVKSASIFPGQVVLAKGFIPRGKTFMVEEIHTERKLTPATPL---QIDRELQ------F 362
            :.::.|.:|..|:||||||:.:|....|:.|:      ..||....||   |..:|.:      .
 Frog   283 VPVDLSELKEYSLFPGQVVIMEGTNSTGRRFV------PTKLYEGVPLPFHQPSKEFEECPQQMV 341

  Fly   363 VVASGPFTDSTDLFYEPLHDLLKYLKDHRPDVLVLTGPFLDADHKMVG--ELAETFDTFFEKMIG 425
            :.|.||||.|..:.|:.|.||:..|....||:.:|.||||||.|:.:.  :|..||:..|::.:.
 Frog   342 ITACGPFTTSDTITYDALKDLIDVLNRDCPDICILLGPFLDAKHEQIENLQLTVTFEDVFKRCLK 406

  Fly   426 GIMESI---GSHTAVLVVTSQKDAMALSVYPTPP-----PALRRTYPNLYMLPDPSLVDLDGFTL 482
            .|:|..   |.|  ::.|.|.:|.....|||.||     || :.....::.:.||..:.::|..|
 Frog   407 MIIEGTRLSGCH--LVFVPSLRDVHHDPVYPQPPFSCFEPA-KEDKDRVHFVADPCTLSVNGVIL 468

  Fly   483 GVTSTDVVDHLLSHEF--AVNAGERMHRAINHLFHQGSFYPLYPPADEDMAYDSQLALKYAQLKQ 545
            |:||||::.|:.:.|.  :|.|.:|..|.:.|:..|.|:|||||| :|::..|.:....||.:..
 Frog   469 GITSTDLLFHMGAEEISSSVGAPDRFSRILRHILTQRSYYPLYPP-NEEINVDYEAFYSYAPMPV 532

  Fly   546 LPNVLILPSDQRHFIRLVNDCLVINPGRVA-DKKGGTFARFLVAPSVPGKAANMFNSVACQVQRI 609
            .|::.|:||:.|:||:.|..|:.|||||:. ...|||:|||||.....|........::.||.||
 Frog   533 TPDIFIVPSELRYFIKDVTGCICINPGRLTKGLVGGTYARFLVKSGAMGSEGKRSPCISAQVVRI 597

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolA2	NP_733206.3	DNA_pol_E_B	362..561	CDD:461142	73/210 (35%)
pola2	NP_001005060.1	POL12	20..585	CDD:227539	176/624 (28%)