Protein Alignment PolA2 and spb70

DIOPT Version :10

• Sequence 1: NP_733206.3
• Gene: PolA2 / 43278
• FlyBaseID: FBgn0005696
• Length: 609
• Species: Drosophila melanogaster
• Sequence 2: NP_587765.1
• Gene: spb70 / 2539135
• PomBaseID: SPCC553.09C
• Length: 574
• Species: Schizosaccharomyces pombe
• Alignment Length: 561
• Identity: 137/561 - (24%)
• Similarity: 232/561 - (41%)
• Gaps: 136/561 - (24%)

  Fly   109 PMLDDYVSESAVDSSALHTPKAKKQSDR--TANLKGAALFSPASYTPQSAKRKAGLETPS---NS 168
            |.||       :|:........|.|.:|  .|.||            |:.:||:..:.|.   :|
pombe    43 PKLD-------LDTFKAFAKDMKFQMERQVKATLK------------QNPERKSIKQIPGMNIDS 88

  Fly   169 VAGKPGDIVDTFGHPKLLAGSSWQSQMEHTVPVTQ--KLLHNDAPLTIANLGYMNDLLTD----- 226
            :.|.|           :...:|..|.|:.:.|.|:  :|..:||...:..|.....::|.
pombe    89 ILGLP-----------VKTTASGDSLMQESKPSTETFELNSSDAGRVLEVLNKELKIVTSKPSAP 142

  Fly   227 -----------RCHNLRVRFNQ--TGPALVDKKLGQAGAAECIWYPQDRQVLQSAGGLH-----A 273
                       :..|.|:.:.:  ....::|.::....|..|..|....:.|.:...|.     .
pombe   143 SKLVIVANFDLKAFNYRIMYQKLYDSSEVLDDRIELFSALTCRKYNISDEDLANPSELTQEPVVV 207

  Fly   274 VGMIHSED---DGPLDAHSAFMAVLDDDVEDEMDPTLTLNFSRVKSASIFPGQVVLAKGFIPRGK 335
            ||.|..|.   .|.|:.:|   .:|:..........:.|....:.|.||||||:|..||..|.|.
pombe   208 VGRIVVESTNLGGRLNQNS---ILLESSRRLGAGVRVRLKVDDLPSYSIFPGQIVSVKGSNPSGN 269

  Fly   336 TFMVEEIHTERKLTPATPLQI----------------DRELQFVVASGPFTDSTDLFYEPLHDLL 384
            .|:.:||      .|..||..                ::.:...:||||::...||.:.||..::
pombe   270 MFIAKEI------LPIPPLPFPSSSKQEHATFVANTNNQPISIYIASGPWSLRDDLSFSPLKSMI 328

  Fly   385 KYLKDHRPDVLVLTGPFLDADHKMV------GELAETFDTFFEKMIGGIMESIGSHTAVLVVTSQ 443
            .|:..:..|:::|.|||||.:|.::      |..|.:.:..|::.:..|:..:  ....:::...
pombe   329 SYVNKNPVDLVILCGPFLDINHILIRTGNITGTSATSLEELFKERVTPILSQL--TCPCILIPHI 391

  Fly   444 KDAMALSVYPT-PPPALRRTY----PNLYMLPDPSLVDLDGFTLGVTSTDVVDH--------LLS 495
            .|  |.|.:|. |..|..|..    .|....|:|.:..::....||::.|::.|        |.|
pombe   392 ND--AASDHPAWPQDAFNRVALGLPSNFKCFPNPCMFSINDVVFGVSTNDILLHTSREELFRLPS 454

  Fly   496 HEFAVNAGERMHRAINHLFHQGSFYPLYP--------PADEDMAYDSQLALKYAQ-LKQLPNVLI 551
            |      |....|.::|:.||..||||:|        |::.|:|:     ||..: |..:|::||
pombe   455 H------GNLFARLVSHVLHQRHFYPLFPGGSLEKCNPSNLDIAH-----LKLGEFLNTMPDILI 508

  Fly   552 LPSDQRHFIRLVNDCLVINPGRVADKKG---GTFARFLVAP 589
            ||||.|:|::.|.:.:.:|||:..  ||   ||||:..:||
pombe   509 LPSDLRYFVKNVENVVSLNPGKAT--KGINLGTFAKLTIAP 547

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolA2	NP_733206.3	DNA_pol_E_B	362..561	CDD:461142	63/226 (28%)
spb70	NP_587765.1	POL12	1..574	CDD:227539	137/561 (24%)