Protein Alignment PolA2 and Pola2

DIOPT Version :10

• Sequence 1: NP_733206.3
• Gene: PolA2 / 43278
• FlyBaseID: FBgn0005696
• Length: 609
• Species: Drosophila melanogaster
• Sequence 2: XP_011246909.1
• Gene: Pola2 / 18969
• MGIID: 99690
• Length: 658
• Species: Mus musculus
• Alignment Length: 705
• Identity: 191/705 - (27%)
• Similarity: 301/705 - (42%)
• Gaps: 150/705 - (21%)

  Fly     3 EELKQQFDEMGVEPADAVLGRCAELAITYNIHDATE--FVEQWMAFSLSHLQGED-PAIENLGDF 64
            ::|.::....|::..|::|.:.|||.:.|.   .||  .|.:.:||..|  .|:. ..::.|..|
Mouse     6 QQLAEELQIFGLDYEDSLLEKLAELCVLYR---QTEDGMVSELIAFCTS--AGKTCLTVDILNSF 65

  Fly    65 ERKVLQLRKDKAGYKATGQKAKSYGSPSVQD-----------------TSSLATYGVMEDDPMLD 112
            |.:||..:..||.:.|    :|..|....:|                 ||........|::.:|.
Mouse    66 EYEVLNKKLSKAWHSA----SKDSGHAGTRDIVSIQELYPFLLKLLSLTSVFRIEAEEEEETLLS 126

  Fly   113 DYVSESAVD----SSALHTPKAKKQSDRTANLKGAALFSPASYTPQSAKRKAGLETPSNSVAGKP 173
            .|.:.|...    ||...||..|:.   .|......|.||:|::|.:        |||.....:.
Mouse   127 SYTTPSKGPLKRVSSTPETPLTKRS---VAARSPRQLLSPSSFSPSA--------TPSQKYTSRT 180

  Fly   174 --GDIVDTFGHPKLLAGSSWQSQMEHTVPVTQKLLHNDAPLT------IANLGYMNDLLTDRCHN 230
              |::|.|||..:   |.|| |....:..|:.|::.:..|||      ...|..:.::||.:...
Mouse   181 NRGEVVTTFGSAQ---GLSW-SGRGGSGSVSLKVVGDPEPLTGSYKAMFQQLMGVREVLTSKIEE 241

  Fly   231 LRVRFNQTGPALVDKKLGQAGAAECIWYPQDRQVLQSAGGLHAVGMIHSEDDGPLDAHSAFMAVL 295
            |       |..|  |:..:..|...:..|....|:       .:|.|..:.:|.|::.|   .:|
Mouse   242 L-------GSEL--KEHHKIEAFTPLLVPAQEPVI-------LLGQIGCDSNGKLNSKS---VIL 287

  Fly   296 DDDVEDEMDPTLTLNFSRVKSASIFPGQVVLAKGFIPRGKTFMVEEIHTERKLTPATPLQI---- 356
            :.|.|......:.::.|.:|..|:||||||:.:||...|:..      |..||....||..
Mouse   288 EGDQEHSYGAQIPVDLSELKEYSLFPGQVVIMEGFNTTGRRL------TATKLYEGVPLPFYQPT 346

  Fly   357 -----DRELQFVVASGPFTDSTDLFYEPLHDLLKYLKDHRPDVLVLTGPFLDADHKMVG--ELAE 414
                 ..:...|||.||:|.|..:.|:||.||:..:...:|||.:|.||||||.|:.|.  :|..
Mouse   347 EEEGASEQTMVVVACGPYTTSDSITYDPLLDLIAIINRDQPDVCILFGPFLDAKHEQVENCKLTS 411

  Fly   415 TFDTFFEKMIGGIME----------------------------------------------SIGS 433
            .|:..|::.:..::|                                              |.||
Mouse   412 PFEDVFKQCLRTVIEGTRRQQFSSVKGATKIKRRCVLSYVHQIQISMFMCQEVAFPSRGPASSGS 476

  Fly   434 HTAVLVVTSQKDAMALSVYPTPP----PALRRTYPNLYMLPDPSLVDLDGFTLGVTSTDVVDHLL 494
            |  ::.|.|.:|.....|||.||    ...|.....:..:.:|..:.::|...|:||||::.|:.
Mouse   477 H--LVFVPSLRDVHHEPVYPQPPFTFSELSREDKKRVQFVSEPCSLSINGVMFGLTSTDLLFHIG 539

  Fly   495 SHEFAVNAG--ERMHRAINHLFHQGSFYPLYPPADEDMAYDSQLALKYAQLKQLPNVLILPSDQR 557
            :.|...::|  :|..|.:.|:..|.|:|||||| .||||.|.:....||||...|:|.|:||:.|
Mouse   540 AEEIFSSSGTSDRFSRVLKHILTQRSYYPLYPP-HEDMAIDYENFYTYAQLPVTPDVFIVPSELR 603

  Fly   558 HFIRLVNDCLVINPGRVA-DKKGGTFARFLV--APSVPGKAANMFNSVACQVQRI 609
            :|::.:..|:.:||||:. .:.||||.|..:  .|...........|||.||.||
Mouse   604 YFVKDIFGCVCVNPGRLTKGQVGGTFGRLYLRRQPKAMDGGGRQGLSVAAQVVRI 658

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolA2	NP_733206.3	DNA_pol_E_B	362..561	CDD:461142	78/252 (31%)
Pola2	XP_011246909.1	Pol_alpha_B_N	21..253	CDD:462470	65/264 (25%)
		DNA_pol_E_B	357..607	CDD:461142	78/252 (31%)