Protein Alignment: DNApol-alpha73 and Pola2

• Sequence 1: NP_733206.3
• Gene: DNApol-alpha73
• FlyBaseID: FBgn0005696
• Length: 609
• Species: Drosophila melanogaster
• Sequence 2: XP_011246909.1
• Gene: Pola2
• MGIID: 99690
• Length: 658
• Species: Mus musculus
• Alignment Length: 705
• Identity: 191/706 (27%)
• Similarity: 301/706 (43%)
• Gaps: 150/706 (21%)

  Fly     3 EELKQQFDEMGVEPADAVLGRCAELAITYNIHDATE--FVEQWMAFSLSHLQGED-PAIENLGDF 64
            ::|.::....|::..|::|.:.|||.:.|.   .||  .|.:.:||..|  .|:. ..::.|..|
Mouse     6 QQLAEELQIFGLDYEDSLLEKLAELCVLYR---QTEDGMVSELIAFCTS--AGKTCLTVDILNSF 65

  Fly    65 ERKVLQLRKDKAGYKATGQKAKSYGSPSVQD-----------------TSSLATYGVMEDDPMLD 112
            |.:||..:..||.:.|    :|..|....:|                 ||........|::.:|.
Mouse    66 EYEVLNKKLSKAWHSA----SKDSGHAGTRDIVSIQELYPFLLKLLSLTSVFRIEAEEEEETLLS 126

  Fly   113 DYVSESAVD----SSALHTPKAKKQSDRTANLKGAALFSPASYTPQSAKRKAGLETPSNSVAGKP 173
            .|.:.|...    ||...||..|:.   .|......|.||:|::|.:        |||.....:.
Mouse   127 SYTTPSKGPLKRVSSTPETPLTKRS---VAARSPRQLLSPSSFSPSA--------TPSQKYTSRT 180

  Fly   174 --GDIVDTFGHPKLLAGSSWQSQMEHTVPVTQKLLHNDAPLT------IANLGYMNDLLTDRCHN 230
              |::|.|||..:   |.|| |....:..|:.|::.:..|||      ...|..:.::||.:...
Mouse   181 NRGEVVTTFGSAQ---GLSW-SGRGGSGSVSLKVVGDPEPLTGSYKAMFQQLMGVREVLTSKIEE 241

  Fly   231 LRVRFNQTGPALVDKKLGQAGAAECIWYPQDRQVLQSAGGLHAVGMIHSEDDGPLDAHSAFMAVL 295
            |       |..|  |:..:..|...:..|....|:       .:|.|..:.:|.|::.|   .:|
Mouse   242 L-------GSEL--KEHHKIEAFTPLLVPAQEPVI-------LLGQIGCDSNGKLNSKS---VIL 287

  Fly   296 DDDVEDEMDPTLTLNFSRVKSASIFPGQVVLAKGFIPRGKTFMVEEIHTERKLTPATPLQI---- 356
            :.|.|......:.::.|.:|..|:||||||:.:||...|:..      |..||....||..
Mouse   288 EGDQEHSYGAQIPVDLSELKEYSLFPGQVVIMEGFNTTGRRL------TATKLYEGVPLPFYQPT 346

  Fly   357 -----DRELQFVVASGPFTDSTDLFYEPLHDLLKYLKDHRPDVLVLTGPFLDADHKMVG--ELAE 414
                 ..:...|||.||:|.|..:.|:||.||:..:...:|||.:|.||||||.|:.|.  :|..
Mouse   347 EEEGASEQTMVVVACGPYTTSDSITYDPLLDLIAIINRDQPDVCILFGPFLDAKHEQVENCKLTS 411

  Fly   415 TFDTFFEKMIGGIME----------------------------------------------SIGS 433
            .|:..|::.:..::|                                              |.||
Mouse   412 PFEDVFKQCLRTVIEGTRRQQFSSVKGATKIKRRCVLSYVHQIQISMFMCQEVAFPSRGPASSGS 476

  Fly   434 HTAVLVVTSQKDAMALSVYPTPP----PALRRTYPNLYMLPDPSLVDLDGFTLGVTSTDVVDHLL 494
            |  ::.|.|.:|.....|||.||    ...|.....:..:.:|..:.::|...|:||||::.|:.
Mouse   477 H--LVFVPSLRDVHHEPVYPQPPFTFSELSREDKKRVQFVSEPCSLSINGVMFGLTSTDLLFHIG 539

  Fly   495 SHEFAVNAG--ERMHRAINHLFHQGSFYPLYPPADEDMAYDSQLALKYAQLKQLPNVLILPSDQR 557
            :.|...::|  :|..|.:.|:..|.|:|||||| .||||.|.:....||||...|:|.|:||:.|
Mouse   540 AEEIFSSSGTSDRFSRVLKHILTQRSYYPLYPP-HEDMAIDYENFYTYAQLPVTPDVFIVPSELR 603

  Fly   558 HFIRLVNDCLVINPGRVA-DKKGGTFARFLV--APSVPGKAANMFNSVACQVQRI 609
            :|::.:..|:.:||||:. .:.||||.|..:  .|...........|||.||.||
Mouse   604 YFVKDIFGCVCVNPGRLTKGQVGGTFGRLYLRRQPKAMDGGGRQGLSVAAQVVRI 658

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-alpha73	NP_733206.3	Pol_alpha_B_N	18..>180	CDD:285602	47/188 (25%)
		DNA_pol_E_B	363..561	CDD:281968	78/252 (31%)
Pola2	XP_011246909.1	Pol_alpha_B_N	20..253	CDD:285602	65/266 (24%)
		DNA_pol_E_B	358..607	CDD:281968	78/252 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930				C238490377
eggNOG	1	0.900				E1_COG5214
Hieranoid	1	1.000
Homologene	1	1.000				H48121
Inparanoid	1	1.050	210	1.000	Inparanoid score	I3634
Isobase	1	0.950		0	Normalized mean entropy	S3706
OMA	1	1.010
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000				FOG0004201
OrthoInspector	1	1.000				T1083848
orthoMCL	1	0.900				OOG5_128793
Panther	1	1.100			LDO	PTHR23061
Phylome	1	0.910		0.667	Consistency score
RoundUp	1	1.030		avgDist	Average_Evolutionary_Distance	R342
TreeFam	1	0.960
	14	13.740