DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNApol-alpha73 and Pola2

DIOPT Version :9

Sequence 1:	NP_733206.3	Gene:	DNApol-alpha73 / 43278	FlyBaseID:	FBgn0005696	Length:	609	Species:	Drosophila melanogaster
Sequence 2:	XP_011246909.1	Gene:	Pola2 / 18969	MGIID:	99690	Length:	658	Species:	Mus musculus

Alignment Length:	705	Identity:	191/705 - (27%)
Similarity:	301/705 - (42%)	Gaps:	150/705 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EELKQQFDEMGVEPADAVLGRCAELAITYNIHDATE--FVEQWMAFSLSHLQGED-PAIENLGDF 64
            ::|.::....|::..|::|.:.|||.:.|.   .||  .|.:.:||..|  .|:. ..::.|..|
Mouse     6 QQLAEELQIFGLDYEDSLLEKLAELCVLYR---QTEDGMVSELIAFCTS--AGKTCLTVDILNSF 65

  Fly    65 ERKVLQLRKDKAGYKATGQKAKSYGSPSVQD-----------------TSSLATYGVMEDDPMLD 112
            |.:||..:..||.:.|    :|..|....:|                 ||........|::.:|.
Mouse    66 EYEVLNKKLSKAWHSA----SKDSGHAGTRDIVSIQELYPFLLKLLSLTSVFRIEAEEEEETLLS 126

  Fly   113 DYVSESAVD----SSALHTPKAKKQSDRTANLKGAALFSPASYTPQSAKRKAGLETPSNSVAGKP 173
            .|.:.|...    ||...||..|:.   .|......|.||:|::|.:        |||.....:.
Mouse   127 SYTTPSKGPLKRVSSTPETPLTKRS---VAARSPRQLLSPSSFSPSA--------TPSQKYTSRT 180

  Fly   174 --GDIVDTFGHPKLLAGSSWQSQMEHTVPVTQKLLHNDAPLT------IANLGYMNDLLTDRCHN 230
              |::|.|||..:   |.|| |....:..|:.|::.:..|||      ...|..:.::||.:...
Mouse   181 NRGEVVTTFGSAQ---GLSW-SGRGGSGSVSLKVVGDPEPLTGSYKAMFQQLMGVREVLTSKIEE 241

  Fly   231 LRVRFNQTGPALVDKKLGQAGAAECIWYPQDRQVLQSAGGLHAVGMIHSEDDGPLDAHSAFMAVL 295
            |       |..|  |:..:..|...:..|....|:       .:|.|..:.:|.|::.|   .:|
Mouse   242 L-------GSEL--KEHHKIEAFTPLLVPAQEPVI-------LLGQIGCDSNGKLNSKS---VIL 287

  Fly   296 DDDVEDEMDPTLTLNFSRVKSASIFPGQVVLAKGFIPRGKTFMVEEIHTERKLTPATPLQI---- 356
            :.|.|......:.::.|.:|..|:||||||:.:||...|:..      |..||....||..
Mouse   288 EGDQEHSYGAQIPVDLSELKEYSLFPGQVVIMEGFNTTGRRL------TATKLYEGVPLPFYQPT 346

  Fly   357 -----DRELQFVVASGPFTDSTDLFYEPLHDLLKYLKDHRPDVLVLTGPFLDADHKMVG--ELAE 414
                 ..:...|||.||:|.|..:.|:||.||:..:...:|||.:|.||||||.|:.|.  :|..
Mouse   347 EEEGASEQTMVVVACGPYTTSDSITYDPLLDLIAIINRDQPDVCILFGPFLDAKHEQVENCKLTS 411

  Fly   415 TFDTFFEKMIGGIME----------------------------------------------SIGS 433
            .|:..|::.:..::|                                              |.||
Mouse   412 PFEDVFKQCLRTVIEGTRRQQFSSVKGATKIKRRCVLSYVHQIQISMFMCQEVAFPSRGPASSGS 476

  Fly   434 HTAVLVVTSQKDAMALSVYPTPP----PALRRTYPNLYMLPDPSLVDLDGFTLGVTSTDVVDHLL 494
            |  ::.|.|.:|.....|||.||    ...|.....:..:.:|..:.::|...|:||||::.|:.
Mouse   477 H--LVFVPSLRDVHHEPVYPQPPFTFSELSREDKKRVQFVSEPCSLSINGVMFGLTSTDLLFHIG 539

  Fly   495 SHEFAVNAG--ERMHRAINHLFHQGSFYPLYPPADEDMAYDSQLALKYAQLKQLPNVLILPSDQR 557
            :.|...::|  :|..|.:.|:..|.|:|||||| .||||.|.:....||||...|:|.|:||:.|
Mouse   540 AEEIFSSSGTSDRFSRVLKHILTQRSYYPLYPP-HEDMAIDYENFYTYAQLPVTPDVFIVPSELR 603

  Fly   558 HFIRLVNDCLVINPGRVA-DKKGGTFARFLV--APSVPGKAANMFNSVACQVQRI 609
            :|::.:..|:.:||||:. .:.||||.|..:  .|...........|||.||.||
Mouse   604 YFVKDIFGCVCVNPGRLTKGQVGGTFGRLYLRRQPKAMDGGGRQGLSVAAQVVRI 658

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-alpha73	NP_733206.3	Pol_alpha_B_N	18..>180	CDD:285602	46/187 (25%)
DNApol-alpha73	NP_733206.3	DNA_pol_E_B	363..561	CDD:281968	78/251 (31%)
Pola2	XP_011246909.1	Pol_alpha_B_N	21..253	CDD:369865	65/264 (25%)
Pola2	XP_011246909.1	DNA_pol_E_B	358..607	CDD:367778	78/251 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832008
Domainoid	1	1.000	130	1.000	Domainoid score	I5207
eggNOG	1	0.900	-	-		E1_COG5214
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H48121
Inparanoid	1	1.050	210	1.000	Inparanoid score	I3662
Isobase	1	0.950	-	0	Normalized mean entropy	S3706
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004882
OrthoInspector	1	1.000	-	-		oto92425
orthoMCL	1	0.900	-	-		OOG6_102459
Panther	1	1.100	-	-	LDO	PTHR23061
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R342
SonicParanoid	1	1.000	-	-		X3994
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.730