DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment grass and KLK4

DIOPT Version :9

Sequence 1:	NP_651543.1	Gene:	grass / 43273	FlyBaseID:	FBgn0039494	Length:	377	Species:	Drosophila melanogaster
Sequence 2:	NP_004908.4	Gene:	KLK4 / 9622	HGNCID:	6365	Length:	254	Species:	Homo sapiens

Alignment Length:	272	Identity:	85/272 - (31%)
Similarity:	129/272 - (47%)	Gaps:	46/272 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 GNFLS---QRVSNGYEVKLSSRPWMALLRYQQFGESRFLCGGAMISERYILTAAHCVHGLQNDLY 173
            |:.:|   .::.||.:....|:||.|.|    ..|:...|.|.::..:::|:||||   .||. |
Human    21 GSLVSGSCSQIINGEDCSPHSQPWQAAL----VMENELFCSGVLVHPQWVLSAAHC---FQNS-Y 77

  Fly   174 EIRLGEHRISTEEDCRQQGRKKKCAPPVVNVGIEKHLIHEKYDARHIMHDIALLKLNRSVPFQKH 238
            .|.||.|.:..:::...|         :|...:.  :.|.:|:...:.:|:.|:||:.||.....
Human    78 TIGLGLHSLEADQEPGSQ---------MVEASLS--VRHPEYNRPLLANDLMLIKLDESVSESDT 131

  Fly   239 IKPICLPITDELKEKAEQIST----YFVTGWGTTENGSSSDVLLQANVPLQPRSACSQAYRRAVP 299
            |:.|.:         |.|..|    ..|:|||...||....||...||.:.....||:.|.....
Human   132 IRSISI---------ASQCPTAGNSCLVSGWGLLANGRMPTVLQCVNVSVVSEEVCSKLYDPLYH 187

  Fly   300 LSQLCVGGG-DLQDSCKGDSGGPLQAPAQYLGEYAPKMVEFGIVSQGVVTCGQISLPGLYTNVGE 363
            .|..|.||| |.:|||.|||||||.... ||.         |:||.|...|||:.:||:|||:.:
Human   188 PSMFCAGGGQDQKDSCNGDSGGPLICNG-YLQ---------GLVSFGKAPCGQVGVPGVYTNLCK 242

  Fly   364 YVQWITDTMASN 375
            :.:||..|:.::
Human   243 FTEWIEKTVQAS 254

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
grass	NP_651543.1	CLIP	32..90	CDD:197829
grass	NP_651543.1	Tryp_SPc	121..371	CDD:238113	82/254 (32%)
KLK4	NP_004908.4	Tryp_SPc	31..250	CDD:238113	82/256 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910