Protein Alignment CG5880 and ZDHHC17

DIOPT Version :10

• Sequence 1: NP_651539.3
• Gene: CG5880 / 43268
• FlyBaseID: FBgn0039489
• Length: 381
• Species: Drosophila melanogaster
• Sequence 2: NP_056151.2
• Gene: ZDHHC17 / 23390
• HGNCID: 18412
• Length: 632
• Species: Homo sapiens
• Alignment Length: 307
• Identity: 80/307 - (26%)
• Similarity: 109/307 - (35%)
• Gaps: 115/307 - (37%)

  Fly    76 SVVSIAYWIGLPFWWAKSQLVTYFLLIVGNWLLLNVVFHYV------MAVITPAGHPPEG----- 129
            |.:.:..::...||    ..||:|...   |..||.:|.::      :|:....|...:.
Human   356 SALPLGIYLATKFW----MYVTWFFWF---WNDLNFLFIHLPFLANSVALFYNFGKSWKSDPGII 413

  Fly   130 -----------VSLVEAVSM-----CGKCIAPKPPRTHHCSICNRCILKMDHHCPWLNNCVGYGN 178
                       |.|.|..|:     |..|:..||.|:.||.:|||||.|.||||||:.||||.||
Human   414 KATEEQKKKTIVELAETGSLDLSIFCSTCLIRKPVRSKHCGVCNRCIAKFDHHCPWVGNCVGAGN 478

  Fly   179 HRYFFLYMTYTTLGCLFLILFGLEIGHKYLWLDHG--ENWTEIEPLEGQPVKFNLSGHIIPVTHP 241
            ||||        :|.||.:||.:      .|:.:|  ..|                |.....|:.
Human   479 HRYF--------MGYLFFLLFMI------CWMIYGCISYW----------------GLHCETTYT 513

  Fly   242 NEYDEFVLPPAVHNLPTPIVDTDAASPGRRRALW-FMAFTN-------VAVVL--------ALGS 290
            .:           ...|.|......||      | |..|.|       |||:|        .||
Human   514 KD-----------GFWTYITQIATCSP------WMFWMFLNSVFHFMWVAVLLMCQMYQISCLG- 560

  Fly   291 LSIWHAKLITRGETSVEAHINEAERKRHLQQQRIYI-NPYNFGTKKN 336
                    ||..|..      .|.|.:|.:.....| :|:|.|..:|
Human   561 --------ITTNERM------NARRYKHFKVTTTSIESPFNHGCVRN 593

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5880	NP_651539.3	DHHC	139..>201	CDD:396215	34/61 (56%)
ZDHHC17	NP_056151.2	Necessary and sufficient for interaction with DNAJC5 and SNAP25. /evidence=ECO:0000250|UniProtKB:Q80TN5	11..305
		ANKYR	52..307	CDD:440430
		ANK repeat	89..120	CDD:293786
		ANK repeat	122..154	CDD:293786
		ANK repeat	156..187	CDD:293786
		ANK repeat	189..221	CDD:293786
		ANK repeat	224..255	CDD:293786
		DHHC	438..568	CDD:396215	56/191 (29%)