Protein Alignment eater and Pear1

DIOPT Version :10

• Sequence 1: NP_651533.3
• Gene: eater / 43262
• FlyBaseID: FBgn0243514
• Length: 1074
• Species: Drosophila melanogaster
• Sequence 2: NP_082736.1
• Gene: Pear1 / 73182
• MGIID: 1920432
• Length: 1034
• Species: Mus musculus
• Alignment Length: 1091
• Identity: 258/1091 - (23%)
• Similarity: 357/1091 - (32%)
• Gaps: 405/1091 - (37%)

  Fly    25 VTRNIKGTAVNVQTR---DCCKGYKKVRSSALRCLAQCKVNCGSGFCTKPNVCTCKKGYVNLNND 86
            |.|.:....|.:.:|   .||:||.:.|.:   |:..|...|..|.|..||.|.|..|:  ...|
Mouse    69 VYRTVYRQVVKMDSRPRLQCCRGYYESRGA---CVPLCAQECVHGRCVAPNQCQCAPGW--RGGD 128

  Fly    87 PSNRCVPYCKG--CSRGTCQSPGRCICSARHLLDKTTNNCIPQCASGCPNGTCITPNNC--SCNK 147
            .|:.|.|...|  |.:       .|.|......|..:..|.      ||:|  :.|.||  .|..
Mouse   129 CSSECAPGMWGPQCDK-------FCHCGNNSSCDPKSGTCF------CPSG--LQPPNCLQPCPA 178

  Fly   148 GYKLNPTTQVCLPTCKDNCAAVNGFC-AAPNRCECNPGFIPKPKSKSFECQPKCKNGCSNGVCRA 211
            |:        ..|.|:.:|......| .....|.|.||          ...|.|...||.|.
Mouse   179 GH--------YGPACQFDCQCYGASCDPQDGACFCPPG----------RAGPSCNVPCSQGT--- 222

  Fly   212 PDKCECNKFYEKDIDGNCVPICENGCV----NGNCTAPDVCQCLTGYTKIGHNVCLAVCPEG--- 269
             |...|.:.|.          |:||.|    .|:|:.|      .|:..:   :|...||||
Mouse   223 -DGFFCPRTYP----------CQNGGVPQGSQGSCSCP------PGWMGV---ICSLPCPEGFHG 267

  Fly   270 --------CQN-GVCVA-PNECSCNAGYTKLEGVCTPVCKDGCVNGFCASPEKCSCNDGYEMDSE 324
                    |.| |:|.. ..:|.|..||  :...|...|..|.....||  |.|.|..|
Mouse   268 PNCTQECRCHNGGLCDRFTGQCHCAPGY--IGDRCQEECPVGRFGQDCA--ETCDCAPG------ 322

  Fly   325 NRCSPVCSGGCKNGFCVAPGKCSCDEGYIKGTGNSC-KPICSKGCENGFCDAPEKCSCNDGYEMD 388
            .||.|            |.|.|.|:.|:   ||:.| :.:|..|.....|..|  |:|:..:.:.
Mouse   323 ARCFP------------ANGACLCEHGF---TGDRCTERLCPDGRYGLSCQEP--CTCDPEHSLS 370

  Fly   389 GENRCSPVCSGGCKNGFCVAPGKCSCDEGYSKETGNSCKPICSK-----GCENGFCDAPEKCSCN 448
                |.|:            .|:|||..|::   |..|...|.:     ||:       |.|.|.
Mouse   371 ----CHPM------------HGECSCQPGWA---GLHCNESCPQDTHGPGCQ-------EHCLCL 409

  Fly   449 DGYEMDSENRCSPVCSGGCKNGFCVA-PGKCSCDEGYSKETGNSCKPICSKGCENGFCDAPEKCS 512
            .|                   |.|:| .|.|.|..||   ||..|..:|........|.:  :||
Mouse   410 HG-------------------GLCLADSGLCRCAPGY---TGPHCANLCPPDTYGINCSS--RCS 450

  Fly   513 CNDGYEMDGENRCSPVCSGGCKNGFCVAPEKCSCDEGYSKETGNSCKPICSNGCENGFCDAPEKC 577
            |.:..      .|||:      :|.|:      |.||:.:  || |...|..|.....|:|  .|
Mouse   451 CENAI------ACSPI------DGTCI------CKEGWQR--GN-CSVPCPLGTWGFNCNA--SC 492

  Fly   578 SC-NDGYEMDGENRCSPVCSGGCKNGFCVAPGKCSCDEGYSKETGNSCKPICSKGCENGFCDAPE 641
            .| :||.       |||            ..|.|:|..|:.   |..|:..|.||.....|.:..
Mouse   493 QCAHDGV-------CSP------------QTGACTCTPGWH---GAHCQLPCPKGQFGEGCASVC 535

  Fly   642 KCSCNDGYEMDSENRCSPVCSGGCKNGFCIAPGKCSCDEGYSKETGNSCKPICSKGCENGFCDAP 706
            .|..:||        |.||            .|:|.|..|:....       |...|..||..|
Mouse   536 DCDHSDG--------CDPV------------HGQCRCQAGWMGTR-------CHLPCPEGFWGA- 572

  Fly   707 EKCSCNDGYEMDSENRCSPVCSGGCKN-GFCVAP-GKCSCDEGYSKETGNSCKPICSKGCENGFC 769
                           .||..|:  ||| |.||:. |.|.|..|:   .|.||:..|..|.....|
Mouse   573 ---------------NCSNTCT--CKNGGTCVSENGNCVCAPGF---RGPSCQRPCPPGRYGKRC 617

  Fly   770 EAPEKCSCNDGYEMDGENRCSPVCSGGCKNGFCIAPGKCSCDEGYSRETGNSCKPICSKGCENGF 834
               .:|.||:.:     :.|.|            :.|.|||..|:   ||    |.||:.|..|.
Mouse   618 ---VQCKCNNNH-----SSCHP------------SDGTCSCLAGW---TG----PDCSEACPPGH 655

  Fly   835 CDAPEKCSCNDGYEMDSENRCSPVCSGGCKNGFCVAP--GKCSCDEGYSKETEISCAPFCKDGC- 896
            ...                :||.:|.  |.:|....|  |.|.|..|::       .|.|.:||
Mouse   656 WGL----------------KCSQLCQ--CHHGGTCHPQDGSCICTPGWT-------GPNCLEGCP 695

  Fly   897 -----VNGLCVSPDFCKCDDGYIFVEESKSCQLDKELLGDYSDCDKNCRNGTCVEGICTCSKQYK 956
                 ||  |  ...|:||                  ||:
Mouse   696 PRMFGVN--C--SQLCQCD------------------LGE------------------------- 713

  Fly   957 LHRNEDDNNLICLPICEPECLNGLCEFPGSCVCWDGESPIDGYSCQ--SMDSLGSLTGHEKSERH 1019
                          :|.||        .|:|||..|.|   |..|:  |.:|...:.....:...
Mouse   714 --------------MCHPE--------TGACVCPPGHS---GADCKMGSQESFTIMPTSPVTHNS 753

  Fly  1020 LKWVFITIVSMAFILAIITTMLIIYIFRKRSYHVDKNEREFGVYFSPNKVD 1070
            |.    .::.:|.:..::..::.::| ..|.:...|......|.:|..::|
Mouse   754 LG----AVIGIAVLGTLVVALIALFI-GYRQWQKGKEHEHLAVAYSTGRLD 799

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eater	NP_651533.3	None
Pear1	NP_082736.1	EMI	24..94	CDD:462204	8/24 (33%)
		EGF_CA	535..580	CDD:473889	18/89 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	823..883
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	925..1034