Protein Alignment eater and Megf10

DIOPT Version :10

• Sequence 1: NP_651533.3
• Gene: eater / 43262
• FlyBaseID: FBgn0243514
• Length: 1074
• Species: Drosophila melanogaster
• Sequence 2: NP_001001979.1
• Gene: Megf10 / 70417
• MGIID: 2685177
• Length: 1147
• Species: Mus musculus
• Alignment Length: 1162
• Identity: 279/1162 - (24%)
• Similarity: 397/1162 - (34%)
• Gaps: 405/1162 - (34%)

  Fly    10 SLLLGLVSAQICTVNVTRNIKGTAVNVQTRDCCKGYKKVRSSALRCLAQCKVNCGSGFCTKPNVC 74
            |..|||:.:.:|      :..|||.::...|                              ||||
Mouse     6 SSCLGLICSLLC------HWVGTASSLNLED------------------------------PNVC 34

  Fly    75 TCKKGY-VNLNND---PSNRCVPYCKGCSRGTCQSPGRCICSARHLLDKTT-------------- 121
            :..:.| |.:...   |.::.  |...|:  ...:..:|   .||.:...|
Mouse    35 SHWESYSVTVQESYPHPFDQI--YYTSCT--DILNWFKC---TRHRISYRTAYRHGEKTMYRRKS 92

  Fly   122 ----------NNCIPQCASGCPNGTCITPNNCSCNKGYKLNPTTQVC-----LPTCKDNCAAVNG 171
                      :.|:|.||..|.:|.||.||.|.|..|:.....:..|     .|.|...|...|.
Mouse    93 QCCPGFYESRDMCVPHCADKCVHGRCIAPNTCQCEPGWGGTNCSSACDGDHWGPHCSSRCQCKNR 157

  Fly   172 FCAAP--NRCECNPGFIPKPKSKSFECQPKCKNGCSNGVCRAPDKCECNKFYEKDIDGNCVPICE 234
            ....|  ..|.|..|:      :.:.|:.:|:.|.....|.  .:|:                |:
Mouse   158 ALCNPITGACHCAAGY------RGWRCEDRCEQGTYGNDCH--QRCQ----------------CQ 198

  Fly   235 NGCVNGNCTAPDVCQCLTGYTKIGHNVCLAVCPEG-----------CQN-GVC-VAPNECSCNAG 286
            ||....:.|..  |:|..|||..   .|..:||.|           ||| ||| ....||||.:|
Mouse   199 NGATCDHITGE--CRCSPGYTGA---FCEDLCPPGKHGPHCEQRCPCQNGGVCHHVTGECSCPSG 258

  Fly   287 YTKLEGVCTPVCKDGCVNGFCASPEKCSCNDGYEMDSENRCSPVCSGGCKNGFC-VAPGKCSCDE 350
            :  :..||...|.:|.....|:  ::|.|::|                   |.| .|.|:|.|..
Mouse   259 W--MGTVCGQPCPEGRFGKNCS--QECQCHNG-------------------GTCDAATGQCHCSP 300

  Fly   351 GYIKGTGNSCKPICSKGCENGFCDAPEKCSCNDGYEMDGENRCSPVCSGGCKNGFCVAPGKCSCD 415
            ||   ||..|:..|..|.....|  .|.|.|.:|              |.|.:    ..|.|.|:
Mouse   301 GY---TGERCQDECPVGSYGVRC--AEACRCVNG--------------GKCYH----VSGTCLCE 342

  Fly   416 EGYSKETGNSCKP-ICSKGCENGFCDAPEKCSCNDGYEMDSENRCSPVCSGGCKNGFCVAPGKCS 479
            .|:|   |..|:. :|.:|.....||  ::|.|:    :|:.:.|.|:            .|:|.
Mouse   343 AGFS---GELCEARLCPEGLYGIKCD--KRCPCH----LDNTHSCHPM------------SGECG 386

  Fly   480 CDEGYSKETGNSCKPICSKGCENGFCDAPEKCSCNDGYEMDG-ENRCSPVCSGGCKNGFCVAPEK 543
            |..|:|   |..|...||.|.....|.  :.|||.:|.:.|. ..||:  |:.|.|...|..|
Mouse   387 CKPGWS---GLYCNETCSPGFYGEACQ--QICSCQNGADCDSVTGRCA--CAPGFKGTDCSTP-- 442

  Fly   544 CSCDEGYSKETGNSCKPICSNGCENGFCDAP--EKCSCNDGYE-MDGENRCSPVCSGG------- 598
              |..|   ..|.:|...|  ||:|....:|  ..|.|..|:. :|    ||..|..|
Mouse   443 --CPLG---RYGINCSSRC--GCKNDAVCSPVDGSCICKAGWHGVD----CSIRCPSGTWGFGCN 496

  Fly   599 ----CKNGFCVAPGKCSCDEGYSKETGNSCKPICSKGCENGFCDAPEKCSCNDG-YEMDSENRCS 658
                |.||     |.|:..:|       :|  .|:.|.....|:.|    |.|| |.::...||.
Mouse   497 LTCQCLNG-----GACNTLDG-------TC--TCAPGWRGAKCEFP----CQDGTYGLNCAERCD 543

  Fly   659 PVCSGGCKNGFCIAPGKCSCDEGYSKETGNSCKPICSKGCENGFCDAPEKCSCNDGYEMDSENRC 723
            ...:.||..    ..|.|.|..|:|   |..|..:|::|.....|..|  |.|.:|..      |
Mouse   544 CSHADGCHP----TTGHCRCLPGWS---GVHCDSVCAEGRWGPNCSLP--CYCKNGAS------C 593

  Fly   724 SPVCSGGCKNGFCVAPGKCSCDEGYSKETGNSCKPICSKGCENGFCEAPEKCSCNDGYEMDGENR 788
            ||            ..|.|.|..|:   .|.:|:.|||.|...                    :|
Mouse   594 SP------------DDGICECAPGF---RGTTCQRICSPGFYG--------------------HR 623

  Fly   789 CSPVC------SGGCKNGFCIAPGKCSCDEGYSRETGNSCKPICSKG-----------C-ENGFC 835
            ||..|      ||.|.:    ..|.|.|..|:   ||..|..:|..|           | .||.|
Mouse   624 CSQTCPQCVHSSGPCHH----ITGLCDCLPGF---TGALCNEVCPSGRFGKNCAGVCTCTNNGTC 681

  Fly   836 DAPEK-CSCNDGY-EMDSENRCSPVCSG-------GCKNG-FCVA-PGKCSCDEGYSKETEISCA 889
            :..:: |.|..|: ..|....|.|...|       .|.|| ||.| .|:|.|..|:   |.:.|.
Mouse   682 NPIDRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAFCSAYDGECKCTPGW---TGLYCT 743

  Fly   890 PFCKDGCVNGLCVSPDFCKCDDGYIFVEESKSCQLDKELLGDYSDCDKNCRNGTCVEGICTCSKQ 954
            ..|..|.....|..  .|:|.:|......|..|......:|.:  |::.|..||...|
Mouse   744 QRCPLGFYGKDCAL--ICQCQNGADCDHISGQCTCRTGFMGRH--CEQKCPAGTYGYG------- 797

  Fly   955 YKLHRNEDDNNLICLPICEPECL-NGLCE-FPGSCVC---WDGES-------------------- 994
                         |..||  :|| |..|: ..|:|.|   |.|..
Mouse   798 -------------CRQIC--DCLNNSTCDHITGTCYCSPGWKGARCDQAGVIIVGNLNSLSRTST 847

  Fly   995 --PIDGYSCQSMDSLGSLTGHEKSERHLKWVFITIVSMAFILAIITTMLIIYIFRKR 1049
              |.|.|      .:|::.|          :.:.::.:.|:||    :.|||..:::
Mouse   848 ALPADSY------QIGAIAG----------IVVLVLVVLFLLA----LFIIYRHKQK 884

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eater	NP_651533.3	None
Megf10	NP_001001979.1	Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion pattern. /evidence=ECO:0000250|UniProtKB:Q96KG7	1..857		271/1119 (24%)
		EMI	31..100	CDD:462204	13/75 (17%)
		EGF_Lam	281..318	CDD:214543	16/58 (28%)
		EGF_CA	542..587	CDD:473889	15/53 (28%)
		Necessary for formation of large intracellular vacuoles. /evidence=ECO:0000250|UniProtKB:Q96KG7	945..1147
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1093..1147