Protein Alignment eater and Megf6

DIOPT Version :10

• Sequence 1: NP_651533.3
• Gene: eater / 43262
• FlyBaseID: FBgn0243514
• Length: 1074
• Species: Drosophila melanogaster
• Sequence 2: NP_075244.1
• Gene: Megf6 / 65049
• RGDID: 621188
• Length: 1574
• Species: Rattus norvegicus
• Alignment Length: 1417
• Identity: 352/1417 - (24%)
• Similarity: 456/1417 - (32%)
• Gaps: 529/1417 - (37%)

  Fly    27 RNIKGTAVNVQTRDCCKGYKKVRSSALRCLAQCKVNCGS--GFCTKP--NV-----CTCKKGYVN 82
            |.:..|......| ||.|:.: :.....||:... .|.|  |.|..|  |.     |.|..|| .
  Rat    94 RQVYATEARTVFR-CCPGWSQ-KPGQEGCLSDVD-ECASANGGCEGPCCNTVGGFYCRCPPGY-Q 154

  Fly    83 LNNDPS-----NRCVPYCKGCSRGTCQSPGRCICSAR-----HLLDKTTNNCIPQCASGCPNGTC 137
            |..|..     :.|..:..||......:||..:|..:     | .|..|...|..|..|  ||.|
  Rat   155 LQGDGKTCQDVDECRAHNGGCQHRCVNTPGSYLCECKPGFRLH-TDGRTCLAISSCTLG--NGGC 216

  Fly   138 --------ITPNNCSCNKGYKLNPTTQVCLPTCKDNCAAVNGFC-------AAPNRCECNPGFIP 187
                    :|.:.|.|...|:|....:.|:.  :..||..||.|       .....|.|:||:..
  Rat   217 QHQCVQLTVTQHRCQCRPQYQLQEDGRRCVR--RSPCAEGNGGCMHICQELRGLAHCGCHPGYQL 279

  Fly   188 KPKSKSF----ECQ---PKCKNGCSNGVCRAPDKCECNKFYEKDIDG-NCVPI-------CENGC 237
            ....|:.    ||.   .:|.:||.|  .:...||.|:..||...|| .|..|       ||.|
  Rat   280 AADRKTCEDVDECALGLAQCAHGCLN--TQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEAG- 341

  Fly   238 VNGNC--------TAPDVCQCLTGY-------TKIGHNVCL--AVCPEGCQNGVCVAPN--ECSC 283
             ||.|        |.| :|.|..||       |.|..:.|.  ..|.:.|.|    .|.  ||||
  Rat   342 -NGGCSHGCSHTSTGP-LCTCPRGYELDEDQKTCIDIDDCANSPCCQQACAN----TPGGYECSC 400

  Fly   284 NAGY-TKLEGV-CTPV---------CKDGCVNGFCASPEKCSCNDGYEMDSENR----------- 326
            .||| ...:|. |..|         |:..|.|  .|...:|.|..||.:|.:.|
  Rat   401 FAGYRLNTDGCGCEDVDECASGHGGCEHHCSN--LAGSFQCFCEAGYRLDEDRRGCTSLEESVVD 463

  Fly   327 ------------------------------------------------------------CSPVC 331
                                                                        ||..|
  Rat   464 LDGRLPFVRPLPHIAVLRDELPRLFQDDYGAEEEAAAAELRGEHTLTEKFVCLDHSFGHDCSLTC 528

  Fly   332 SGGCKNGFCVAPGK--CSCDEGYIKGTGNSCKPICSKGCENGFCDAPEKCSCNDGYEMD---GEN 391
            . .|:||....||:  |.|.||:   ||..|...|........|.:|  |:|.:|...|   |..
  Rat   529 D-DCRNGGTCFPGQDGCDCPEGW---TGIICNETCPPDTFGKNCSSP--CTCQNGGTCDPVLGAC 587

  Fly   392 RCSPVCSG-----GCKNGF----------CVAPGKCS-------CDEGY---------------- 418
            ||.|..||     ||..||          |...|:|.       ||.|.
  Rat   588 RCPPGVSGAHCEDGCPKGFYGKHCRKKCHCANRGRCHRLYGACLCDPGLYGRFCHLACPPWAFGP 652

  Fly   419 -----------------SKETGNSCK-----PICSKGCENGF----CDAPEKCSCNDGYEMD--- 454
                             .|:...|||     ..|...||:||    |  ..:|:|..|...|
  Rat   653 GCSEDCLCEQSHTRSCNPKDGSCSCKAGFQGERCQAECESGFFGPGC--RHRCTCQPGVACDPVS 715

  Fly   455 --SENRCSP------------------VCSGGCKNGFCV-AP-----GKCSCDEGYSKETGNSCK 493
              ...:|.|                  .|||.|.   || ||     |:|.|..|   :||..|.
  Rat   716 GECRTQCPPGYQGEDCGQECPVGTFGVNCSGSCS---CVGAPCHRVTGECLCPPG---KTGEDCG 774

  Fly   494 PICSKG------------CENGFCDAPE--KCSCNDGYEMDGENRCSPVCSGG-----------C 533
            ..|.:|            ||:|....||  .|.|..|:.   .:||...||.|           |
  Rat   775 ADCPEGRWGLGCQEICPACEHGASCNPETGTCLCLPGFV---GSRCQDTCSAGWYGTGCQIRCAC 836

  Fly   534 KN-GFC-VAPEKCSCDEGYSKETGNSCKPICSNG-----------CE--NGFCDAPE-KCSCNDG 582
            .| |.| ....:|||..|:   ||.||:..|.:|           |.  :|.|||.. .|.|..|
  Rat   837 ANDGHCDPTTGRCSCAPGW---TGLSCQRACDSGHWGPDCIHPCNCSAGHGNCDAVSGLCLCEAG 898

  Fly   583 YEMDGENRCSPVCSGGCKNGFCVAPG---KCSCDEGYS-KETGNSCK-------PICSKGCENGF 636
            ||       .|.|...|:.|: ..|.   ||.|:.|.: .....:|.       ..|...|..||
  Rat   899 YE-------GPRCEQSCRQGY-YGPSCEQKCRCEHGAACDHVSGACTCPAGWRGSFCEHACPAGF 955

  Fly   637 ----CDAPEKCSCNDGYEMDSEN-------------------------RCSPVCSGGCKNGFCI- 671
                ||:  .|:|:.|...|:..                         .||.:|:  |.||...
  Rat   956 FGLDCDS--ACNCSAGAPCDAVTGSCICPAGRWGPRCAQSCPPLTFGLNCSQICT--CFNGASCD 1016

  Fly   672 -APGKCSCDEGYSKETGNSCKPICSKG-----------CEN-GFCDAP--EKCSCNDGYE-MDSE 720
             ..|:|.|..|:   .|.:|...|..|           |.| |.|| |  .:|:|.:|:. :..|
  Rat  1017 SVTGQCHCAPGW---MGPTCLQACPPGLYGKNCQHSCLCRNGGRCD-PILGQCTCPEGWTGLACE 1077

  Fly   721 NRCSP-VCSGGCK-------NGFC-VAPGKCSCDEGYSKETGNSCKPICSKGCENGFCEAPEKCS 776
            |.|.| ..:.||:       .|.| ...|.|.|..|:   ||:.|:..|..|.....||  |.|:
  Rat  1078 NECLPGHYAAGCQLNCSCLHGGICDRLTGHCLCPAGW---TGDKCQSSCVSGTFGVHCE--EHCA 1137

  Fly   777 CNDG---YEMDGENRC-----SPVCSGGCKNGF--------CIAP---------GKCSCDEGYSR 816
            |..|   :.:.|...|     .|.|...|..|:        |:.|         |:|.|..|:
  Rat  1138 CRKGASCHHVTGACFCPPGWRGPHCEQACPRGWFGEACAQRCLCPTNASCHHVTGECRCPPGF-- 1200

  Fly   817 ETGNSCKPICSKG-----CENGFCDAPEK----------CSCNDGY------EMDSENRCSPVCS 860
             ||.||:..|..|     ||: .|..|.:          |:|..||      :.....|..|.|.
  Rat  1201 -TGLSCEQACQPGTFGKDCEH-LCQCPGETWACDPASGVCTCAAGYHGTGCLQRCPSGRYGPGCE 1263

  Fly   861 GGCK---NGFC-VAPGKCSCDEGY-SKETEISC-----APFCKDGC----------VNGLCVSPD 905
            ..||   .|.| .|.|.|.|..|: ..:..::|     .|.|...|          |:|.|:
  Rat  1264 HICKCLNGGTCDPATGACYCPAGFLGADCSLACPQGRFGPSCAHVCACRQGAACDPVSGACI--- 1325

  Fly   906 FCKCDDGYIFVEESKSCQLDKELLGDYSDCDKNCRN-GTC--VEGICTCSKQYKLHRNEDDNNLI 967
               |..|...|.....|..|:  .|...:....||| |.|  ..|.|:|...:
  Rat  1326 ---CSPGKTGVRCEHGCPQDR--FGKGCELKCACRNGGLCHATNGSCSCPLGW------------ 1373

  Fly   968 CLPICEPEC----------------LNGLCE-FPGSCVCWDGESPIDGYSCQ 1002
            ..|.||..|                .||.|| ..|:|:|..|   ..|.:|:
  Rat  1374 MGPHCEHACPAGRYGAACLLECFCQNNGSCEPTTGACLCGPG---FYGQACE 1422

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eater	NP_651533.3	None
Megf6	NP_075244.1	EMI	41..113	CDD:462204	6/19 (32%)
		FXa_inhibition	127..162	CDD:464251	12/35 (34%)
		vWFA	<154..202	CDD:469594	10/48 (21%)
		FXa_inhibition	209..245	CDD:464251	10/37 (27%)
		vWFA	<237..285	CDD:469594	11/49 (22%)
		vWFA	<284..325	CDD:469594	13/42 (31%)
		FXa_inhibition	338..373	CDD:464251	12/37 (32%)
		vWFA	<371..410	CDD:469594	14/42 (33%)
		vWFA	<413..452	CDD:469594	11/40 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1555..1574