Protein Alignment eater and PEAR1

DIOPT Version :10

• Sequence 1: NP_651533.3
• Gene: eater / 43262
• FlyBaseID: FBgn0243514
• Length: 1074
• Species: Drosophila melanogaster
• Sequence 2: XP_016856723.1
• Gene: PEAR1 / 375033
• HGNCID: 33631
• Length: 1125
• Species: Homo sapiens
• Alignment Length: 1110
• Identity: 274/1110 - (24%)
• Similarity: 370/1110 - (33%)
• Gaps: 399/1110 - (35%)

  Fly   128 CASG--CPNGTCIT--PNNCSCNKGYKLNPTTQVC------------LPTCKDNCAAVNGFCAAP 176
            |:||  |......:  |.:.....|....||.|:.            |||.:.:       |..|
Human    11 CSSGVRCRGAGAQSKGPEDTGPQSGLFCMPTAQISADRSSRLLAAAPLPTLRRS-------CCRP 68

  Fly   177 NRCE--CNPGF--------------------------IPKPKSKS---FECQPKCKNGCSNGVCR 210
            .:|.  |.|.|                          :|.|:|.:   ..|.|:..   ::|..|
Human    69 LQCHRLCVPSFSWLWACGWLELSTPVIPIPAASGKASLPPPRSPTPAPSACSPQSP---ASGPGR 130

  Fly   211 APD-------------------------------------------KCECNKFYEKDIDGNCVPI 232
            ||.                                           :| |:.|||.  .|.|||:
Human   131 APILAPSPQTQRKLLASRDSFCMVCVGVVYRTVYRQVVKTDHRQRLQC-CHGFYES--RGFCVPL 192

  Fly   233 CENGCVNGNCTAPDVCQCLTGYTKIGHNVCLAVCPEGCQNGVCVAPNECSCNAGYTKLEGVCTPV 297
            |...||:|.|.||:.|||:.|:.  |.: |.:.|..|.....|..|..|..|:......|||:
Human   193 CAQECVHGRCVAPNQCQCVPGWR--GDD-CSSECAPGMWGPQCDKPCSCGNNSSCDPKSGVCS-- 252

  Fly   298 CKDGCVNGFCASPEKCSCNDGYEMDSENRCSPVCSGGCK-NGFCVAP--GKCSCDEGYIKGTGNS 359
            |..|.....|..|    |..||       ..|.|...|: :|....|  |.|.|.   .:.||.|
Human   253 CPSGLQPPNCLQP----CTPGY-------YGPACQFRCQCHGAPCDPQTGACFCP---AERTGPS 303

  Fly   360 CKPICSKGCENGFCDAPEKCSCNDGYEMDGENRCSPVCSGGCKNGFCVAPGKCSCDEGYSKETGN 424
            |...||:|....||.:...|. |.|.....:..||  |..|.....|..|    |.||:.   |.
Human   304 CDVSCSQGTSGFFCPSTHSCQ-NGGVFQTPQGSCS--CPPGWMGTICSLP----CPEGFH---GP 358

  Fly   425 SCKPICSKGCEN-GFCDA-PEKCSCNDGYEMDSENRCSPVCSGG-----CKNGFCVAP------- 475
            :|...|.  |.| |.||. ..:|.|..||..|   ||...|..|     |......||
Human   359 NCSQECR--CHNGGLCDRFTGQCRCAPGYTGD---RCREECPVGRFGQDCAETCDCAPDARCFPA 418

  Fly   476 -GKCSCDEGYSKETGNSCKPICSKGCENGF----CDAPEKCSCNDGYEMDGENRCSPVCSGGCKN 535
             |.|.|:.|:   ||:.|   ..:.|.:||    |.||  |:|:..:.:.    |.|:      |
Human   419 NGACLCEHGF---TGDRC---TDRLCPDGFYGLSCQAP--CTCDREHSLS----CHPM------N 465

  Fly   536 GFCVAPEKCSCDEGYSKETGNSCKPICSN-----GCENGFCDAPEKCSCNDGYEMDGENRCSPVC 595
            |      :|||..|::   |..|...|..     ||:       |.|.|..|
Human   466 G------ECSCLPGWA---GLHCNESCPQDTHGPGCQ-------EHCLCLHG------------- 501

  Fly   596 SGGCKNGFCVA-PGKCSCDEGYSKETGNSCKPICSKGCENGFCDAPEKCSCNDGYEMDSENRCSP 659
                  |.|.| .|.|.|..||   ||..|..:|........|.|  :|||.:..      .|||
Human   502 ------GVCQATSGLCQCAPGY---TGPHCASLCPPDTYGVNCSA--RCSCENAI------ACSP 549

  Fly   660 VCSGGCKNGFCIAPGKCSCDEGYSKETGNSCKPICSKGCENGFCDAPEKCSCNDGYEMDSENRCS 724
            :            .|:|.|.||:.:  || |...|..|.. ||       |||...:...|..||
Human   550 I------------DGECVCKEGWQR--GN-CSVPCPPGTW-GF-------SCNASCQCAHEAVCS 591

  Fly   725 PVCSGGCKNGFCVAPGKCSCDEGYSKETGNSCKPICSKGCENGFCEAPEKCSCNDGYEMDGENRC 789
            |            ..|.|:|..|:.   |..|:..|.||.....|.:  :|.|      |..:.|
Human   592 P------------QTGACTCTPGWH---GAHCQLPCPKGQFGEGCAS--RCDC------DHSDGC 633

  Fly   790 SPVCSGGCKNGFCIAPGKCSCDEGYSRETGNSCKPICSKG-----CENGFCDAPEKCSCNDGYEM 849
            .||            .|:|.|..|:   .|..|...|.:|     |.|       .|:|.:|
Human   634 DPV------------HGRCQCQAGW---MGARCHLSCPEGLWGVNCSN-------TCTCKNG--- 673

  Fly   850 DSENRCSPVCSGGCKNGFCV-APG----KC--SCDEG-YSKETEISCAPFCKDGCVNGLCVSPD- 905
               ..|.|      :||.|| |||    .|  ||..| |.|.    |.| ||  |.|.....|.
Human   674 ---GTCLP------ENGNCVCAPGFRGPSCQRSCQPGRYGKR----CVP-CK--CANHSFCHPSN 722

  Fly   906 -FCKCDDGYIFVEESKSCQLDKELLGDYSD-CDKNCR---NGTC--VEGICTCSKQYKLHRNEDD 963
             .|.|..|:...:.|:.|.     .|.:.: |.:.|:   .|||  .:|.|.|...:..|.
Human   723 GTCYCLAGWTGPDCSQPCP-----PGHWGENCAQTCQCHHGGTCHPQDGSCICPLGWTGHH---- 778

  Fly   964 NNLICLPICEPECLNGLCEFP-------------GSCVCWDGESPIDGYSCQ------------- 1002
                ||..|........|..|             |:|||..|.|   |..|:
Human   779 ----CLEGCPLGTFGANCSQPCQCGPGEKCHPETGACVCPPGHS---GAPCRIGIQEPFTVMPTT 836

  Fly  1003 --SMDSLGSLTGHEKSERHLKWVFITIVSMAFILAIITTMLIIYIFRKRSYHVDKNEREFGVYFS 1065
              :.:|||:                 ::.:|.:.:::..::.::| ..|.:...|......|.:|
Human   837 PVAYNSLGA-----------------VIGIAVLGSLVVALVALFI-GYRHWQKGKEHHHLAVAYS 883

  Fly  1066 PNKVD 1070
            ..::|
Human   884 SGRLD 888