back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eater and STAB1

DIOPT Version :10

Sequence 1:	NP_651533.3	Gene:	eater / 43262	FlyBaseID:	FBgn0243514	Length:	1074	Species:	Drosophila melanogaster
Sequence 2:	XP_005265030.1	Gene:	STAB1 / 23166	HGNCID:	18628	Length:	2595	Species:	Homo sapiens

Alignment Length:	1217	Identity:	262/1217 - (21%)
Similarity:	377/1217 - (30%)	Gaps:	502/1217 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 QSPGRCICSARHLLDKTTNNCIPQCASGCPNGTCITPNNCS----CNKGYKLNPTTQVCLPTCKD 164
            ::|||.:.....:|...::.|:...|... ...|:   ||:    |.:|::|..|.       :.
Human  1240 EAPGRSLIGLSGVLTVGSSRCLHSHAEAL-REKCV---NCTRRFRCTQGFQLQDTP-------RK 1293

  Fly   165 NCAAVNGF---------CAAPNRC-ECNPGFIPKPKSKSFECQPKCKNG----CS-NGVCR---- 210
            :|...:||         ||...:. :|.|||.      ...|:| |..|    || :|.|:
Human  1294 SCVYRSGFSFSRGCSYTCAKKIQVPDCCPGFF------GTLCEP-CPGGLGGVCSGHGQCQDRFL 1351

  Fly   211 APDKCECNKFYEKDIDGNCVPICENGCVNGNCTAPDVCQCLTGYTKIGHNVCLAVCPEGCQ-NGV 274
            ...:|.|::.:.    |....:||.|....|||.  ||.|..|           :|.||.| :|.
Human  1352 GSGECHCHEGFH----GTACEVCELGRYGPNCTG--VCDCAHG-----------LCQEGLQGDGS 1399

  Fly   275 CVAPNECSCNAGYTKL---EGVCTPVCKDGC-VNGFC----ASPEKCSCNDGYEMDSENR--CSP 329
            ||      ||.|:..|   :.:.:|.|...| .|..|    |....|:|..||   |.|.  ||.
Human  1400 CV------CNVGWQGLRCDQKITSPQCPRKCDPNANCVQDSAGASTCACAAGY---SGNGIFCSE 1455

  Fly   330 V--CS---GGCK---NGFCVAPGK--CSCDEGYIKGTGNSCKPICSKGCENGFC--------DAP 376
            |  |:   |||.   |...||||:  |:|.:||: |.|..|:.|.|....:|.|        ..|
Human  1456 VDPCAHGHGGCSPHANCTKVAPGQRTCTCQDGYM-GDGELCQEINSCLIHHGGCHIHAECIPTGP 1519

  Fly   377 EK--CSCNDGYEMDGENRCSPV--CS---GGCK-NGFCVAPG----KCSCDEGYSKETGNSCK-- 427
            ::  |||.:||..||...|..:  ||   |||. ...|.:.|    .|:||..::...|.:|:
Human  1520 QQVSCSCREGYSGDGIRTCELLDPCSKNNGGCSPYATCKSTGDGQRTCTCDTAHTVGDGLTCRAR 1584

  Fly   428 -------------------------------------PICSK----------------------G 433
                                                 .:.|.                      |
Human  1585 VGLELLRDKHASFFSLRLLEYKELKGDGPFTIFVPHADLMSNLSQDELARIRAHRQLVFRYHVVG 1649

  Fly   434 C---------ENGFCDA----PEKCSCNDG----------------------------------- 450
            |         |.|:..|    |.:.|..:|
Human  1650 CRRLRSEDLLEQGYATALSGHPLRFSEREGSIYLNDFARVVSSDHEAVNGILHFIDRVLLPPEAL 1714

  Fly   451 -YEMDSENRCSPVCSGGCKNGFCVAPGKCSCDEGYSKETG----NSCKPICSKGCENGF-----C 505
             :|.|.    :|:..   :|....|.|     .||...:|    ....|:..:.....|     .
Human  1715 HWEPDD----APIPR---RNVTAAAQG-----FGYKIFSGLLKVAGLLPLLREASHRPFTMLWPT 1767

  Fly   506 DAPEKCSCNDG----YEMDGENRCSPVCSGG-CKNGFCVA---------------PEKCSCDEGY 550
            ||..:....|.    |..|..::.:.:..|. .:|...:|               |...||....
Human  1768 DAAFRALPPDRQAWLYHEDHRDKLAAILRGHMIRNVEALASDLPNLGPLRTMHGTPISFSCSRTR 1832

  Fly   551 SKE---------------------------------TGNSC-----KPICSNGCENGFCDAPEKC 577
            :.|                                 .|..|     :|:..|.|.....:.|
Human  1833 AGELMVGEDDARIVQRHLPFEGGLAYGIDQLLEPPGLGARCDHFETRPLRLNTCSICGLEPP--- 1894

  Fly   578 SCNDGYEMDGE-NRC----------SPVCSGGCKNGFCVAPGKCSCDEGYSKETGNSC-----KP 626
             |.:|.:..|. ..|          .|:.|.|.::.: |.|......:|..:....:|     ||
Human  1895 -CPEGSQEQGSPEACWRFYPKFWTSPPLHSLGLRSVW-VHPSLWGRPQGLGRGCHRNCVTTTWKP 1957

  Fly   627 ICSKGCENGFCDAPEKCSCNDGYEMDSENRCSPVCS--GGCKNGFCIAPGKCSCDEGYSKETGNS 689
            .|..|.....|.|     |..|       ..|| ||  |.|.:|.. ..|:|.|..|::   |.:
Human  1958 SCCPGHYGSECQA-----CPGG-------PSSP-CSDRGVCMDGMS-GSGQCLCRSGFA---GTA 2005

  Fly   690 CKPICSKGCENGFCDAPEKCSCNDGYEMDSENRCSPVCSGGCKNGFCVAPGKCSCDEGYSKETGN 754
            |: :|:.|.....|.|   |.|.      ...||.....|.         |.|.||||:   ||.
Human  2006 CE-LCAPGAFGPHCQA---CRCT------VHGRCDEGLGGS---------GSCFCDEGW---TGP 2048

  Fly   755 SC------KPICSKGC-ENGFCEAPEKCSCNDGYEMDGENRCSPVCSGG--CKNGFCIAPGKCSC 810
            .|      :|:|:..| ....|.|...|.|:.|||.||.     ||:..  |::|.    |.||
Human  2049 RCEVQLELQPVCTPPCAPEAVCRAGNSCECSLGYEGDGR-----VCTVADLCQDGH----GGCS- 2103

  Fly   811 DEGYSRETGNSCKPICSKGCENGFCDAPEKCSC-----NDGYEMDSENRCSPVCSGGC-KNGFCV 869
                  |..|     ||:      ......|:|     .||:...:.|.|:....||| ::..|:
Human  2104 ------EHAN-----CSQ------VGTMVTCTCLPDYEGDGWSCRARNPCTDGHRGGCSEHANCL 2151

  Fly   870 APG----KCSCDEGYSKE----TEISCAPFCKDGCVNGLCVSPDFC----KCDD----------- 911
            :.|    :|.|..||..:    .|.|..|.  |.|:.    .|..|    .|.|
Human  2152 STGLNTRRCECHAGYVGDGLQCLEESEPPV--DRCLG----QPPPCHSDAMCTDLHFQEKRAGVF 2210

  Fly   912 ---------GYIFVEESKSCQLDKELLGDY--------------------------------SDC 935
                     |..|.|...:|:....:|..:                                :||
Human  2211 HLQATSGPYGLNFSEAEAACEAQGAVLASFPQLSAAQQLGFHLCLMGWLANGSTAHPVVFPVADC 2275

  Fly   936 D------------KN------------------CRNGTCVEGICTCS 952
            .            ||                  ||||...:||.||:
Human  2276 GNGRVGIVSLGARKNLSERWDAYCFRVQDVACRCRNGFVGDGISTCN 2322

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.