Protein Alignment eater and Megf6

DIOPT Version :10

• Sequence 1: NP_651533.3
• Gene: eater / 43262
• FlyBaseID: FBgn0243514
• Length: 1074
• Species: Drosophila melanogaster
• Sequence 2: NP_001156449.1
• Gene: Megf6 / 230971
• MGIID: 1919351
• Length: 1572
• Species: Mus musculus
• Alignment Length: 1435
• Identity: 358/1435 - (24%)
• Similarity: 467/1435 - (32%)
• Gaps: 523/1435 - (36%)

  Fly    27 RNIKGTAVNVQTRDCCKGY--KKVRSSALRCLAQCKVNCGSGFCTKP--NV-----CTCKKGYVN 82
            |.:..|......| ||.|:  |..:...|..:.:| .|...| |..|  |.     |.|..|| .
Mouse    93 RQVYATEARTVFR-CCPGWSQKPGQEGCLSDVDEC-ANANGG-CEGPCCNTVGGFYCRCPPGY-Q 153

  Fly    83 LNNDPS-----NRCVPYCKGCSRGTCQSPGRCICSAR-----HLLDKTTNNCIPQCASGCPNGTC 137
            |..|..     :.|..:..||......:||..:|..:     | .|..|...|..|..|  ||.|
Mouse   154 LQGDGKTCQDVDECRSHNGGCQHRCVNTPGSYLCECKPGFRLH-TDGRTCLAISSCTLG--NGGC 215

  Fly   138 --------ITPNNCSCNKGYKLNPTTQVCLPTCKDNCAAVNGFC-------AAPNRCECNPGFIP 187
                    :|.:.|.|...|:|....:.|:.  :..||..||.|       .....|.|:||:..
Mouse   216 QHQCVQLTVTQHRCQCRPQYQLQEDGRRCVR--RSPCADGNGGCMHTCQELRGLAHCGCHPGYQL 278

  Fly   188 KPKSKSF----ECQ---PKCKNGCSNGVCRAPDKCECNKFYEKDIDG-NCVPI-------CENGC 237
            ....|:.    ||.   .:|.:||.|  .:...||.|:..||...|| .|..|       ||.|
Mouse   279 AADRKACEDVDECALGLAQCAHGCLN--TQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEAG- 340

  Fly   238 VNGNC--------TAPDVCQCLTGY-TKIGHNVCLAVCPEGCQNGVC---VAPN-----ECSCNA 285
             ||.|        |.| :|.|..|| .......|:.:  :.|.|..|   |..|     ||||.|
Mouse   341 -NGGCSHGCSHTSTGP-LCTCPRGYELDEDQKTCIDI--DDCANSPCCQQVCANTPGGYECSCFA 401

  Fly   286 GYTKLEGVCTPVCKDGCVNGFCASPEKCS---------CNDGYEMDSENR-CSPV---------- 330
            ||......|.....|.|.:|.......||         |..||.:|.:.| |:|:
Mouse   402 GYRLNTDGCGCEDVDECASGHSGCEHHCSNLAGSFQCFCEAGYRLDEDRRGCTPLEESVVDLDGQ 466

  Fly   331 -------------------------------------------------------CS---GGCKN 337
                                                                   ||   ..|:|
Mouse   467 LPFVRPLPHIAVLGDELPQLFQDDYGAEEEAVAELRGEHTLTEKFVCLDHSFGHDCSLTCDDCRN 531

  Fly   338 GFCVAPG--KCSCDEGYIKGTGNSCKPICSKGCENGFCDAPEKCSCNDGYEMD---GENRCSPVC 397
            |....||  .|.|.||:   ||..|...|........|.:|  |.|.:|...|   |..||.|..
Mouse   532 GGTCFPGLDGCDCPEGW---TGIICNETCPPDTFGKNCSSP--CICQNGGTCDPVSGACRCPPGV 591

  Fly   398 SG-----GCKNGF----------CVAPGKCS-------CDEG-YSKETGNSCKPI-----CSKGC 434
            ||     ||..||          |...|:|.       ||.| |.:....:|.|.     ||:.|
Mouse   592 SGAHCEDGCPKGFYGKHCRKKCHCANRGRCHRLYGACLCDPGLYGRFCHLACPPWAFGPGCSEDC 656

  Fly   435 -----ENGFCDAPE-KCSCNDGY-----EMDSE---------NRCS------------------- 460
                 ....|::.: .|||..|:     |.:.|         |||:
Mouse   657 LCEQSHTRSCNSKDGSCSCKAGFQGERCEAECEPGSFGPGCRNRCTCRPGVACDPVSGECRTQCP 721

  Fly   461 ------------PV------CSGGCKNGFCV-AP-----GKCSCDEGYSKETGNSCKPICSKG-- 499
                        ||      |||.|.   || ||     |:|.|..|   :||..|...|.:|
Mouse   722 PGYQGEDCGQECPVGTFGVNCSGSCS---CVGAPCHRVTGECLCPPG---KTGEDCGADCPEGRW 780

  Fly   500 ----------CENG-FCDAPE--KCSCNDGYEMDGENRCSPVCSGG-----------CKN-GFC- 538
                      ||:| .|| ||  .|.|..|:.   .:||...|..|           |.| |.|
Mouse   781 GLGCQEICPACEHGASCD-PETGTCLCLPGFV---GSRCQDACPAGWFGTGCQMRCACANDGHCH 841

  Fly   539 VAPEKCSCDEGYSKETGNSCKPICSNG-----------CE--NGFCDAPE-KCSCNDGYEMDGEN 589
            .|..:|||..|:   ||.||:..|.:|           |.  :|.|||.. .|.|..|||
Mouse   842 PATGRCSCAPGW---TGLSCQRACDSGHWGPDCIHPCNCSAGHGNCDAVSGLCLCEAGYE----- 898

  Fly   590 RCSPVCSGGCKNGFCVAPG---KCSCDEGYS-KETGNSCK-------PICSKGCENGF--CDAPE 641
              .|.|...|:.|: ..||   ||.|:.|.: .....:|.       ..|...|..||  .|...
Mouse   899 --GPQCEQWCRQGY-FGPGCEQKCRCEHGATCDHVSGACTCPAGWRGSFCEHACPAGFFGLDCGS 960

  Fly   642 KCSCNDGYEMDSEN-------------------------RCSPVCSGGCKNGFCIAP--GKCSCD 679
            .|:|:.|...|:..                         .||.:|:  |.||....|  |:|.|.
Mouse   961 ACNCSAGAPCDAVTGSCICPAGRWGPHCAQTCPPLTFGLNCSQICT--CFNGASCDPVLGQCHCA 1023

  Fly   680 EGYSKETGNSCKPICSKG-----------CEN-GFCDAP--EKCSCNDGYE-MDSENRCSPVCSG 729
            .|:   .|.:|...|..|           |.| |.|| |  .:|:|.:|:. :..||.|.|...|
Mouse  1024 PGW---MGPTCLQACPAGLYGKNCQHSCLCRNGGNCD-PILGQCTCPEGWTGLACENECLPGHHG 1084

  Fly   730 -GCK-NGFCV-------APGKCSCDEGYSKETGNSCKPICSKGCENGFCEAPEKCSCNDG---YE 782
             ||: |..|:       ..|.|.|..|:   ||:.|:..|..|.....||  |.|:|..|   :.
Mouse  1085 AGCRLNCSCLNGGTCDRLTGHCRCPTGW---TGDKCQSPCVSGMFGVHCE--EHCACRKGATCHH 1144

  Fly   783 MDGENRCSP-----VCSGGCKNGF--------CIAP---------GKCSCDEGYSRETGNSCKPI 825
            :.|...|.|     .|...|..|:        |..|         |:|.|..|:   ||..|:..
Mouse  1145 VTGACLCPPGWRGSHCEQACPRGWFGEACAQRCHCPPGASCHHVSGECHCPPGF---TGPGCEQA 1206

  Fly   826 CSKG-----CENGFCDAPEK----------CSCNDGYE-MDSENRC-----SPVCSGGCK---NG 866
            |..|     ||:. |..|.:          |.|..||. .|.:.||     .|.|...||   .|
Mouse  1207 CQPGTFGKDCEHP-CQCPGETWACHPASGACVCAAGYHGTDCQQRCPSGRYGPGCEQICKCLNGG 1270

  Fly   867 FC-VAPGKCSCDEGY-SKETEISC-----APFCKDGC----------VNGLCVSP---------- 904
            .| .|.|.|.|..|: ..:..::|     .|.|...|          |:|.|:.|
Mouse  1271 TCDPATGACYCPAGFLGADCSLACPQGRFGPSCAHVCTCGQGAACDPVSGTCICPPGKTGGHCER 1335

  Fly   905 ------------DFCKCDDGYIFVEESKSCQLDKELLGDYSDCDKNC----------------RN 941
                        ..|.|.:|.:....:.||......:|.:  |:..|                .|
Mouse  1336 GCPQDRFGKGCEHKCACRNGGLCHATNGSCSCPLGWMGPH--CEHACPAGRYGAACLLECSCQNN 1398

  Fly   942 GTC--VEGICTCSKQYKLHRNEDD-----NNLICLPICEPECLNGL-CE-FPGSCVCWDGESPID 997
            |:|  ..|.|.|...:.....||.     :...|..:|  ||..|. |: ..|.|:|..|   ..
Mouse  1399 GSCEPTSGACLCGPGFYGQACEDTCPAGFHGSGCQRVC--ECQQGAPCDPVSGRCLCPAG---FH 1458

  Fly   998 GYSCQ 1002
            |..|:
Mouse  1459 GQFCE 1463

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eater	NP_651533.3	None
Megf6	NP_001156449.1	EMI	41..112	CDD:462204	6/19 (32%)
		FXa_inhibition	126..161	CDD:464251	12/37 (32%)
		vWFA	<153..201	CDD:469594	10/48 (21%)
		FXa_inhibition	208..244	CDD:464251	10/37 (27%)
		FXa_inhibition	250..285	CDD:464251	10/34 (29%)
		vWFA	<283..324	CDD:469594	13/42 (31%)
		FXa_inhibition	337..372	CDD:464251	12/37 (32%)
		vWFA	<370..409	CDD:469594	13/40 (33%)
		vWFA	<412..451	CDD:469594	9/38 (24%)