Protein Alignment eater and MEGF6

DIOPT Version :10

• Sequence 1: NP_651533.3
• Gene: eater / 43262
• FlyBaseID: FBgn0243514
• Length: 1074
• Species: Drosophila melanogaster
• Sequence 2: XP_011539188.1
• Gene: MEGF6 / 1953
• HGNCID: 3232
• Length: 1560
• Species: Homo sapiens
• Alignment Length: 1361
• Identity: 356/1361 - (26%)
• Similarity: 456/1361 - (33%)
• Gaps: 477/1361 - (35%)

  Fly    41 CCKGYKKVRSSALRCL-AQCKVN-C-GSGFCTKPNV--CTCKKGYVNLNNDPSNRC---VPYCK- 96
            ||:|:.: :.....|| |:|..: | ..|.|...:.  |.|..|:      ...||   |..|:
Human   172 CCRGWMQ-QPDEEGCLSAECSASLCFHGGRCVPGSAQPCHCPPGF------QGPRCQYDVDECRT 229

  Fly    97 ---GCSRGTCQSPGRCICSAR-----HLLDKTTNNCIPQCASGCPNGTC--------ITPNNCSC 145
               ||......:||..:|..:     | .|..|...|..||.|  ||.|        ||.:.|.|
Human   230 HNGGCQHRCVNTPGSYLCECKPGFRLH-TDSRTCLAINSCALG--NGGCQHHCVQLTITRHRCQC 291

  Fly   146 NKGYKLNPTTQVCL---------PTCKDNCAAVNGFCAAPNRCECNPGFIPKPKSKSF----ECQ 197
            ..|::|....:.|:         .:|...|..|.|..    ||||:.|:......|:.    ||.
Human   292 RPGFQLQEDGRHCVRRSPCANRNGSCMHRCQVVRGLA----RCECHVGYQLAADGKACEDVDECA 352

  Fly   198 ---PKCKNGCSNGVCRAPDKCECNKFYEKDIDG-NCVPI-------CE---NGCVNG--NCTAPD 246
               .:|.:||.|  .:...||.|:..||...|| .|..|       ||   .||.:|  :.:|..
Human   353 AGLAQCAHGCLN--TQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSAGP 415

  Fly   247 VCQCLTGY-TKIGHNVCLAV--------CPEGCQNGVCVAPN--ECSCNAGY-TKLEGV-CTPV- 297
            :|.|..|| .......|:.|        |.:.|.|.    |.  ||.|.||| ...:|. |..|
Human   416 LCTCPRGYELDTDQRTCIDVDDCADSPCCQQVCTNN----PGGYECGCYAGYRLSADGCGCEDVD 476

  Fly   298 --------CKDGCVNGFCASPEKCSCNDGYEMDSENR-CSPV----------------------- 330
                    |:..|.|  .|...:|||..||.:..:.| |||:
Human   477 ECASSRGGCEHHCTN--LAGSFQCSCEAGYRLHEDRRGCSPLEEPMVDLDGELPFVRPLPHIAVL 539

  Fly   331 ------------------------------------------CS---GGCKNGFCVAPG--KCSC 348
                                                      ||   ..|:||.....|  .|.|
Human   540 QDELPQLFQDDDVGADEEEAELRGEHTLTEKFVCLDDSFGHDCSLTCDDCRNGGTCLLGLDGCDC 604

  Fly   349 DEGYIKGTGNSCKPIC-----SKGCENGFCDAPEKCSCNDGYEMD---GENRCSPVCSG-----G 400
            .||:   ||..|...|     .|.|.       ..|||.:|...|   |..||.|..||     |
Human   605 PEGW---TGLICNETCPPDTFGKNCS-------FSCSCQNGGTCDSVTGACRCPPGVSGTNCEDG 659

  Fly   401 CKNGF----------CVAPGKCS-------CDEG-YSKETGNSCKP------------------- 428
            |..|:          |...|:|.       ||.| |.:....:|.|
Human   660 CPKGYYGKHCRKKCNCANRGRCHRLYGACLCDPGLYGRFCHLTCPPWAFGPGCSEECQCVQPHTQ 724

  Fly   429 ICSK-----GCENGF----CDAP-----------EKCSCNDGYEMDSEN-----RC--------- 459
            .|.|     .|:.||    |.|.           :.|:|..|...||.:     ||
Human   725 SCDKRDGSCSCKAGFRGERCQAECELGYFGPGCWQACTCPVGVACDSVSGECGKRCPAGFQGEDC 789

  Fly   460 ---SPV------CSGGCKNGFCVAP-----GKCSCDEGYSKETGNSCKPICSKG----------- 499
               .||      ||..|..|  .||     |:|.|..|   .||..|:..|.:|
Human   790 GQECPVGTFGVNCSSSCSCG--GAPCHGVTGQCRCPPG---RTGEDCEADCPEGRWGLGCQEICP 849

  Fly   500 -CENGF-CDAPE--KCSCNDGYEMDGENRCSPVCSGG-----------CKN-GFC-VAPEKCSCD 547
             |::.. || ||  .|.|..|:.   .:||..||..|           |.| |.| .|...|||.
Human   850 ACQHAARCD-PETGACLCLPGFV---GSRCQDVCPAGWYGPSCQTRCSCANDGHCHPATGHCSCA 910

  Fly   548 EGYSKETGNSCK---------PICSNGCE----NGFCDA-PEKCSCNDGYEMDGENRCSPVCSGG 598
            .|:   ||.||:         |.||:.|.    :|.||| ...|.|..||       ..|.|...
Human   911 PGW---TGFSCQRACDTGHWGPDCSHPCNCSAGHGSCDAISGLCLCEAGY-------VGPRCEQQ 965

  Fly   599 CKNGFCVAPG---KCSCDEGYS-KETGNSCK-------PICSKGCENGF--CDAPEKCSCNDGYE 650
            |..|. ..||   :|.|..|.: .....:|.       ..|...|..||  .|....|:|..|..
Human   966 CPQGH-FGPGCEQRCQCQHGAACDHVSGACTCPAGWRGTFCEHACPAGFFGLDCRSACNCTAGAA 1029

  Fly   651 MDSEN------------RCSPVCSG-----------GCKNGFCIAP--GKCSCDEGYSKETGNSC 690
            .|:.|            ||:..|..           .|.||....|  |:|.|..|:   .|.||
Human  1030 CDAVNGSCLCPAGRRGPRCAETCPAHTYGHNCSQACACFNGASCDPVHGQCHCAPGW---MGPSC 1091

  Fly   691 KPICSKG-----------CEN-GFCD-APEKCSCNDGYE-MDSENRCSP-----VC--SGGCKNG 734
            ...|..|           |:| |.|| ....|:|.:|:. :..|..|.|     .|  ||||.||
Human  1092 LQACPAGLYGDNCRHSCLCQNGGTCDPVSGHCACPEGWAGLACEKECLPRDVRAGCRHSGGCLNG 1156

  Fly   735 FCVAP--GKCSCDEGYSKETGNSCKPICSKGCENGFCEAPEKCSCNDG---YEMDGENRCSPVCS 794
            ....|  |:|.|..|:   ||:.|:..|.:|.....|  .::|||..|   :.:.|..||.|..:
Human  1157 GLCDPHTGRCLCPAGW---TGDKCQSPCLRGWFGEAC--AQRCSCPPGAACHHVTGACRCPPGFT 1216

  Fly   795 G-GCKNGFCIAPGKCSCDEGYSRETGNSCKPICSKGCENGFC-DAPEKCSCNDGYEMDS-ENRCS 856
            | ||:.         :|..|   ..|..|..:|....||..| .|...|||..||...| :.||.
Human  1217 GSGCEQ---------ACPPG---SFGEDCAQMCQCPGENPACHPATGTCSCAAGYHGPSCQQRCP 1269

  Fly   857 P---------VCSGGCKN-GFC-VAPGKCSCDEGY-SKETEISC-----APFCKD--GCVNGLCV 902
            |         :|  ||.| |.| .|.|.|.|..|: ..:..::|     .|.|..  ||..|...
Human  1270 PGRYGPGCEQLC--GCLNGGSCDAATGACRCPTGFLGTDCNLTCPQGRFGPNCTHVCGCGQGAAC 1332

  Fly   903 SP--DFCKCDDGYIFVEESKSCQLDKELLGDYSDCDKNCRN-GTC--VEGICTCSKQYKLHRNED 962
            .|  ..|.|..|...|...:.|..::..:|....|  :||| |.|  ..|.|:|...:.....|
Human  1333 DPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTC--SCRNGGLCHASNGSCSCGLGWTGRHCE- 1394

  Fly   963 DNNLICLP-----ICEPECL---NGLCE-FPGSCVCWDG------ESP----IDGYSCQSM 1004
               |.|.|     .|..||.   |..|| ..|:|.|..|      |.|    ..|..||.:
Human  1395 ---LACPPGRYGAACHLECSCHNNSTCEPATGTCRCGPGFYGQACEHPCPPGFHGAGCQGL 1452

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eater	NP_651533.3	None
MEGF6	XP_011539188.1	EMI	107..176	CDD:462204	2/3 (67%)
		vWFA	<215..261	CDD:469594	11/52 (21%)
		FXa_inhibition	268..304	CDD:464251	12/37 (32%)
		vWFA	<342..384	CDD:469594	13/43 (30%)
		FXa_inhibition	397..432	CDD:464251	10/34 (29%)
		vWFA	<472..511	CDD:469594	11/40 (28%)