Protein Alignment eater and Stab1

DIOPT Version :10

• Sequence 1: NP_651533.3
• Gene: eater / 43262
• FlyBaseID: FBgn0243514
• Length: 1074
• Species: Drosophila melanogaster
• Sequence 2: NP_619613.2
• Gene: Stab1 / 192187
• MGIID: 2178742
• Length: 2571
• Species: Mus musculus
• Alignment Length: 1077
• Identity: 238/1077 - (22%)
• Similarity: 326/1077 - (30%)
• Gaps: 470/1077 - (43%)

  Fly   138 ITPNNCSCNKGYKLNPTTQVCLPTCKDNCAAVNGFCAAPNRCECNPGFIPKPKSKSFEC----QP 198
            |.|.:|.       ....|..|.:|.| |.|:|.....||..:.:  ..||      ||    .|
Mouse   650 ILPKHCD-------EEQHQTVLGSCVD-CQALNTSVCPPNSVKMD--IFPK------ECVYIHDP 698

  Fly   199 K----CKNGCSNGVCRAPDKCECNKFYEKDIDGNCVPICENGCVNGNCTAPDVCQCLTGYTKIGH 259
            .    .|.||::         .||:           .|.:.||..| ...||..||..|::
Mouse   699 NGLNVLKKGCAD---------YCNQ-----------TITKRGCCKG-FFGPDCTQCPGGFS---- 738

  Fly   260 NVCLAV--CPEGCQ-NGVCVAPNECSCNAGYTKLEGVCTPVCKD------------GCVNGFCAS 309
            |.|...  |.:|.: ||.|:      |...|   :|:...:|.|            |||:|.|
Mouse   739 NPCYGKGNCSDGVRGNGACL------CFPDY---KGIACHICSDPKKHGEQCQEDCGCVHGLC-- 792

  Fly   310 PEKCSCNDGYEMDSENRCSPVCSGGCKNGFCVAPGKCS--CDEGYIKGTGNSCKPICSKGC-ENG 371
                          :||  |...|.|:.|.| |||...  |:|    ..||......::.| .:.
Mouse   793 --------------DNR--PGSGGVCQQGTC-APGFQGRFCNE----SMGNCGSTGLAQPCHSDA 836

  Fly   372 FCDAPE---KCSCNDGYEMDG-----ENRCSPVCSGGC-KNGFCVAPG-----KCSCDEGYSKET 422
            .|...|   :|.|:||:|.:|     .|.||....||| :|..|| ||     .|.|.:|:|.:
Mouse   837 HCVIQEGVARCVCHDGFEGNGFSCKRSNPCSRPDRGGCSENAECV-PGDLGTHHCICHKGWSGD- 899

  Fly   423 GNSCKPICSKGCE-NGFCDA----------PEKCSC-----NDGYEMDSENRCSPV--C---SGG 466
            |..|..|...|.: .|.|.|          ..:|:|     .:|||      |||:  |   :||
Mouse   900 GRICVAIDECGLDTRGGCHADALCSYVGPGQSRCTCKLGFAGNGYE------CSPIDPCRVGNGG 958

  Fly   467 CKN-GFCVAPG----KCSCDEGYSKETGNSC---------------------------KPICSK- 498
            |.. ..|.|.|    .|:|...:..: |.||                           .|..|:
Mouse   959 CHGLATCKAVGGGQRVCTCPPHFGGD-GFSCYGDIIQELEANAHFSAFSQWFKNSSITLPADSRV 1022

  Fly   499 ----------------------------------------------------------------- 498
                                                                             
Mouse  1023 TALVPSESAIRRLSLEDQAFWLQPKMLPELARAHFLQGAFSEEELARLNGQQVATLSATTRWQIH 1087

  Fly   499 ------GCENGFCDAPEKCS--------------------------------------------- 512
                  ..:|...|.|:..:
Mouse  1088 NISGKVWVQNATVDVPDLLATNGILHIVSQVLLPPRGDMQTGPGLLQQLDSVPAFRLFGEQLKHH 1152

  Fly   513 -----------------CNDGYEMDGENRCSPVCS------------------GGCKNGFCVAPE 542
                             .|...|..|.|....:.:                  ||.:|.. :.|.
Mouse  1153 KLVAQIEAAKAYTIFVPTNHSLETQGNNSVLGIDTVRHHVILGEALSVEVLRKGGHRNSL-LGPA 1216

  Fly   543 KCSCDEGYSKETGNSCKP---------------------ICSNGCENGFCDA-PEKC-------S 578
            .......:|.:...:..|                     :.|:.|.:...:| .|||       .
Mouse  1217 HWLVFYNHSGQPEVNHMPLEGPLLEAPGSSLFGLSGILAVGSSRCLHSHAEALREKCINCTRKFR 1281

  Fly   579 CNDGYEMDGENRCSPV----------CSGGCKNGFCVAPGKCSCDEGYSKETGNSCKP------- 626
            |..|:::....|.|.|          ||..|.....|.    .|..|:   .|..|:|
Mouse  1282 CTQGFQLQDTPRKSCVYRSGLSFSRGCSYTCAKKIQVP----DCCPGF---FGTLCEPCPGGLGG 1339

  Fly   627 ICS--KGCENGFCDAPEKCSCNDGY-----EMDSENRCSPVCSGGCKNGFCIAPGKCSCDEGYSK 684
            :||  ..|::.|....| |.|.:|:     ||....|..|.||           |.|.||.|..:
Mouse  1340 VCSGHGQCQDRFLGNGE-CRCQEGFHGTACEMCELGRYGPTCS-----------GVCDCDHGLCQ 1392

  Fly   685 E--TGN-SCKPICSKGCENGFCD-------APEKCSCNDGYEMDSENRCSPVCSGGCK-NG-FCV 737
            |  .|| ||  :|..|.:...||       .|:||..|.....||....:.||:.|.. || :|.
Mouse  1393 EGLRGNGSC--VCHAGWQGLRCDQKITDHQCPKKCDPNANCIQDSAGIPACVCAAGYSGNGSYCS 1455

  Fly   738 APGKCSCDEGYSKETGNSCKPI--CSKGCENGFCEAP--EKCSCNDGYEMDGE-----NRCSPVC 793
            ....|:...|       .|.|.  |:|       .||  ..|:|.|||..|||     |.|. |.
Mouse  1456 EVDPCASGHG-------GCSPYANCTK-------VAPGQRTCTCQDGYTGDGELCQEINSCL-VH 1505

  Fly   794 SGGCK-NGFCIAPG----KCSCDEGYSRETGNSCKPICSKGCENGFCDAPEKCSCNDGYEMDSEN 853
            :|||. :..||..|    .|||.||||.:...:||.:             :.||.|:|
Mouse  1506 NGGCHVHAECIPTGPQQVSCSCREGYSGDGIQTCKLL-------------DPCSQNNG------- 1550

  Fly   854 RCSPVCSGGCKNGFCVAPGK--CSCDEGYSKETEISC 888
            .|||...  ||:   ...|:  ||||..::....|:|
Mouse  1551 GCSPYAV--CKS---TGDGQRTCSCDATHTVGDGITC 1582

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eater	NP_651533.3	None
Stab1	NP_619613.2	FAS1	499..644	CDD:441906
		EGF_3	831..860	CDD:463759	9/28 (32%)
		EGF_3	915..946	CDD:463759	8/36 (22%)
		EGF_3	952..988	CDD:463759	10/36 (28%)
		Fasciclin	1000..1121	CDD:396845	5/120 (4%)
		EGF_3	1460..1496	CDD:463759	16/49 (33%)
		EGF_3	1502..1539	CDD:463759	15/37 (41%)
		EGF_3	1545..1582	CDD:463759	15/48 (31%)
		Fasciclin	1607..1711	CDD:396845
		Fasciclin	1737..1867	CDD:396845
		EGF_Lam	<1992..2021	CDD:214543
		EGF_3	2095..2130	CDD:463759
		EGF_3	2136..2173	CDD:463759
		Link_Domain	2208..2300	CDD:470631
		FAS1	2367..2463	CDD:214719