Protein Alignment eater and Stab1

DIOPT Version :10

• Sequence 1: NP_651533.3
• Gene: eater / 43262
• FlyBaseID: FBgn0243514
• Length: 1074
• Species: Drosophila melanogaster
• Sequence 2: XP_008769275.1
• Gene: Stab1 / 100363145
• RGDID: 2324745
• Length: 2630
• Species: Rattus norvegicus
• Alignment Length: 1302
• Identity: 277/1302 - (21%)
• Similarity: 383/1302 - (29%)
• Gaps: 614/1302 - (47%)

  Fly   138 ITPNNCSCNKGYKLNPTTQVCLPTCKDNCAAVNGFCAAPNRCECNPGFIPKPKSKSFEC----QP 198
            |.|.:|.       ....|..|.:|.| |.|:|.....||..:.:  ..||      ||    .|
  Rat   653 ILPKHCD-------EEQHQTVLGSCVD-CQALNTSICPPNSVKMD--IFPK------ECVYTHDP 701

  Fly   199 K----CKNGCSNGVCRAPDKCECNKFYEKDIDGNCVPICENGCVNGNCTAPDVCQCLTGYTKIGH 259
            .    .|.||:.         .||:           .|.:.||..| ...||..||..|::
  Rat   702 AGLNVLKKGCAE---------YCNQ-----------TITKRGCCKG-FFGPDCTQCPGGFS---- 741

  Fly   260 NVCLAV--CPEGCQ-NGVCVAPNECSCNAGYTKLEGVCTPVCKD------------GCVNGFCAS 309
            |.|...  |.:|.| ||.|:      |...|   :|:...:|.:            |||:|.|
  Rat   742 NPCYGKGNCSDGVQGNGACL------CFPDY---KGIACHICSNPNKHGEQCQEDCGCVHGLC-- 795

  Fly   310 PEKCSCNDGYEMDSENRCSPVCSGGCKNGFCVAPGKCS--CDE-----GYIKGTGNSCKPICSKG 367
                          :||  |...|.|:.|.| |||...  |:|     |.: |....|.|
  Rat   796 --------------DNR--PGSGGVCQQGTC-APGFQGRFCNESMGNCGSL-GLAQPCHP----- 837

  Fly   368 CENGFCDAPE---KCSCNDGYEMDGEN--RCSPVCS----GGC-KNGFCVAPG-----KCSCDEG 417
              :..|...|   :|.|:||:|.:|.:  |.|| ||    ||| :|..|| ||     :|.|.:|
  Rat   838 --DAHCVIQEGVARCVCHDGFEGNGFSCKRSSP-CSHPDRGGCSENAECV-PGDLGTHQCICHKG 898

  Fly   418 YSKETGNSCKPICSKGCE-NGFCDA----------PEKCSC-----NDGYEMDSENRCSPV--C- 463
            :|.: |..|..|...|.: .|.|.|          ..:|:|     .||||      |||:  |
  Rat   899 WSGD-GRICVAIDECGLDTRGGCHADALCSYVGPGQSRCTCKLGFAGDGYE------CSPIDPCR 956

  Fly   464 --SGGCKN-GFCVAPG----KCSC-----DEGYS-------KETGNSCKPICSKGCENGFCDAPE 509
              :|||.. ..|.|.|    .|:|     .:|:|       :...|:.....|:..:|.....|.
  Rat   957 VGNGGCHGLATCKAVGGGQRVCTCPPHFGGDGFSCYGDIIQELEANAHFSAFSQWFKNSSITLPA 1021

  Fly   510 --KCSC-----------------------------------------NDGYEMD----------- 520
              |.:.                                         :.|:::|
  Rat  1022 DGKLTALVPSESAIRRLRPEDQAFWLQPKTLPELVRWGELGRKGHGGDSGWDLDPSQTMLREFPW 1086

  Fly   521 ----GENRCSPVC-------------------------------------------------SGG 532
                ||.|...:|                                                 ||.
  Rat  1087 LTKVGEPRLKELCNLVQSPPPPTLLLRAHFLQGAFSEEELARLSGQQVATLSATTHWQIHNTSGR 1151

  Fly   533 CK--------------NGF------CVAPEKCSCDEG---------------------------- 549
            .:              ||.      .:.|.:.....|
  Rat  1152 VQVQNATVDVPDLLATNGVLHIISQVLLPPRGDMQTGPGLLQQLDSVPAFRLFGEQLKHHKLVAQ 1216

  Fly   550 --------------YSKET-GN------------------------------------------- 556
                          :|.|| ||
  Rat  1217 IEAAKAYTIFVPTNHSLETQGNKSILGIDIVRHHVILGEALSVEVLRKGGHRNSLLGPAHWLVFY 1281

  Fly   557 --SCKP---------------------------ICSNGCENGFCDA-PEKC-------SCNDGYE 584
              |.:|                           :.|:.|.:...:| .|||       .|..|::
  Rat  1282 NHSGQPEVNHVPLEGPLLEAPGSALFGLSGILAVGSSRCLHSHAEALREKCVNCTRKFRCTQGFQ 1346

  Fly   585 MDGENRCSPV----------CSGGCKNGFCVAPGKCSCDEGYSKETGNSCKP-------ICS--K 630
            :....|.|.|          ||..|.....|.    .|..|:   .|..|:|       :||  .
  Rat  1347 LQDTPRKSCVYRSGLSFSRGCSYTCAKKIQVP----DCCPGF---FGTLCEPCPGGLGGVCSGHG 1404

  Fly   631 GCENGFCDAPEKCSCNDGY-----EMDSENRCSPVCSGGCKNGFCIAPGKCSCDEGYSKE--TGN 688
            .|::.|....| |.|.:|:     ||....|..|.||           |.|.||.|..:|  .||
  Rat  1405 QCQDRFLGNGE-CRCQEGFHGTACEMCELGRYGPTCS-----------GVCDCDHGLCQEGLRGN 1457

  Fly   689 -SCKPICSKGCENGFCD-------APEKCSCNDGYEMDSENRCSPVCSGGCKNGFCVAPGKCS-- 743
             ||  ||:.|.:...||       .|:||..|.....||..  .|||.  |..|:......||
  Rat  1458 GSC--ICNVGWQGLRCDQKITDRQCPKKCDPNANCIQDSAG--IPVCV--CAAGYSGNGSYCSEV 1516

  Fly   744 --CDEGYSKETGNSCKPI--CSKGCENGFCEAP--EKCSCNDGYEMDGE-----NRCSPVCSGGC 797
              |..|:     ..|.|.  |:|       .||  ..|:|.|||..|||     |.|. |.:|||
  Rat  1517 DPCTSGH-----GGCSPYANCTK-------VAPGQRTCTCLDGYTGDGELCQEINSCL-VHNGGC 1568

  Fly   798 K-NGFCIAPG----KCSCDEGYSRETGNSCKPICSKGCENGFCDAPEKCSCNDGYEMDSENRCSP 857
            . |..||..|    .|:|.||||.:...|||.:             :.||.|:|       .|||
  Rat  1569 HVNAECIPTGPQQVSCNCREGYSGDGIQSCKLL-------------DPCSQNNG-------GCSP 1613

  Fly   858 VCSGGCKNGFCVAPGK--CSCDEGYSKETEISCAPFCKDGCVNGLCVSPDFCKCDDGYIFVEESK 920
            ...  ||:   ...|:  ||||..::....|:|                      .|.:.:|..:
  Rat  1614 YAV--CKS---TGDGQRTCSCDSTHTVGDGITC----------------------HGRVGLELLR 1651

  Fly   921 SCQLD---------KELLGD--------YSDCDKNCRNGTCV----------------------- 945
            :....         |||.||        :||...|...|...
  Rat  1652 NKYASFFSLHLLEYKELKGDGPFTIFVPHSDLISNMSQGELARMRAHRQLVFRYHVLGCRKLGSQ 1716

  Fly   946 ----EGICTCSKQYKLHRNEDD-----NNLICLPICEPECLNGLCEF------PGSCVCWDGES- 994
                :|..|....:.|..:|.:     |:...:...:.|.:||:..|      |...:.|:.::
  Rat  1717 ELLDQGYVTALSGHTLRISEREGSIYLNDFARVVSSDHEAVNGVLHFIDRVLLPPDVLHWEADTI 1781

  Fly   995 PI 996
            ||
  Rat  1782 PI 1783

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eater	NP_651533.3	None
Stab1	XP_008769275.1	FAS1	502..647	CDD:441906
		EGF_3	834..863	CDD:463759	10/35 (29%)
		EGF_3	918..949	CDD:463759	9/36 (25%)
		EGF_3	955..991	CDD:463759	10/35 (29%)
		Fasciclin	<1100..1180	CDD:396845	4/79 (5%)
		Fasciclin	1224..1313	CDD:470649	7/88 (8%)
		EGF_3	1519..1555	CDD:463759	16/47 (34%)
		EGF_3	1561..1595	CDD:463759	15/34 (44%)
		EGF_3	1604..1641	CDD:463759	15/48 (31%)
		Fasciclin	1666..1770	CDD:396845	18/103 (17%)
		Fasciclin	1796..1926	CDD:396845
		EGF_Lam	2037..2082	CDD:238012
		EGF_3	2154..2189	CDD:463759
		EGF_3	2195..2232	CDD:463759
		Link_Domain	2267..2359	CDD:470631
		FAS1	2426..2521	CDD:214719
		Fasciclin	391..494	CDD:470649