Protein Alignment Tl and LRRC3

DIOPT Version :10

• Sequence 1: NP_001262995.1
• Gene: Tl / 43222
• FlyBaseID: FBgn0262473
• Length: 1117
• Species: Drosophila melanogaster
• Sequence 2: NP_112153.1
• Gene: LRRC3 / 81543
• HGNCID: 14965
• Length: 257
• Species: Homo sapiens
• Alignment Length: 269
• Identity: 63/269 - (23%)
• Similarity: 105/269 - (39%)
• Gaps: 87/269 - (32%)

  Fly   434 FVSTNGLRHLHLDHNDIDLQQPLLDIMLQTQIN-------SPFGYMHGLLTLNLRNNSIIFVYND 491
            |.|..||:.:   ..||    |...::|:...|       ..|.::|
Human    49 FCSLRGLQEV---PEDI----PANTVLLKLDANKISHLPDGAFQHLH------------------ 88

  Fly   492 WKNTMLQLRELDLSYNNISSLGYEDLAFLSQNRLHVNMTHNKIRRIALPEDVHLGEGYNNNLVHV 556
                  :|||||||:|.|.::|....|.|:.....:::::|:|:||  |:|. ||:    ....:
Human    89 ------RLRELDLSHNAIEAIGSATFAGLAGGLRLLDLSYNRIQRI--PKDA-LGK----LSAKI 140

  Fly   557 DLNDNPLVCDCTI---LWFIQLVRGVHKPQYSRQFKLRTDRLVCSQPNVLEGTPVRQIEPQTLIC 618
            .|:.|||.|:|.:   ||.::|     .|.       ..|.:.|.       |.|::
Human   141 RLSHNPLHCECALQEALWELKL-----DPD-------SVDEIACH-------TSVQE-------- 178

  Fly   619 PLDFSDDPRERKCPRG---CNCHVRTYDKALVINC---HSGNLTHVPRLPNLHKNMQLMELHLEN 677
              :|...|..:....|   |:...||.|.|:::..   .:..:.:|  :..:..|.:....|||
Human   179 --EFVGKPLVQALDAGASLCSVPHRTTDVAMLVTMFGWFAMVIAYV--VYYVRHNQEDARRHLE- 238

  Fly   678 NTLLRLPSA 686
             .|..||||
Human   239 -YLKSLPSA 246

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tl	NP_001262995.1	LRR_8	174..233	CDD:404697
		leucine-rich repeat	176..198	CDD:275380
		leucine-rich repeat	199..222	CDD:275380
		LRR	222..576	CDD:443914	39/151 (26%)
		leucine-rich repeat	223..270	CDD:275380
		leucine-rich repeat	271..294	CDD:275380
		leucine-rich repeat	295..320	CDD:275380
		leucine-rich repeat	321..343	CDD:275380
		leucine-rich repeat	344..367	CDD:275380
		leucine-rich repeat	368..391	CDD:275380
		leucine-rich repeat	392..415	CDD:275380
		leucine-rich repeat	416..439	CDD:275380	2/4 (50%)
		leucine-rich repeat	440..474	CDD:275380	7/40 (18%)
		leucine-rich repeat	475..498	CDD:275380	0/22 (0%)
		leucine-rich repeat	499..520	CDD:275380	11/20 (55%)
		leucine-rich repeat	523..552	CDD:275380	8/28 (29%)
		LRRCT	561..619	CDD:214507	13/60 (22%)
		LRRNT	631..667	CDD:214470	7/41 (17%)
		PPP1R42	<660..752	CDD:455733	9/27 (33%)
		leucine-rich repeat	664..693	CDD:275380	9/23 (39%)
		leucine-rich repeat	694..715	CDD:275380
		leucine-rich repeat	716..737	CDD:275380
		LRRCT	751..800	CDD:214507
		TIR	858..996	CDD:214587
LRRC3	NP_112153.1	LRRNT	32..68	CDD:214470	7/25 (28%)
		leucine-rich repeat	48..65	CDD:275378	7/22 (32%)
		LRR 1	65..86		3/20 (15%)
		leucine-rich repeat	66..89	CDD:275378	4/46 (9%)
		LRR_8	69..125	CDD:404697	17/79 (22%)
		LRR 2	89..110		10/20 (50%)
		leucine-rich repeat	90..114	CDD:275378	12/23 (52%)
		LRR 3	114..135		7/23 (30%)
		leucine-rich repeat	115..138	CDD:275378	8/29 (28%)
		LRR 4	136..157		6/20 (30%)