DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tl and LRRC3

DIOPT Version :9

Sequence 1:	NP_001262995.1	Gene:	Tl / 43222	FlyBaseID:	FBgn0262473	Length:	1117	Species:	Drosophila melanogaster
Sequence 2:	NP_112153.1	Gene:	LRRC3 / 81543	HGNCID:	14965	Length:	257	Species:	Homo sapiens

Alignment Length:	269	Identity:	63/269 - (23%)
Similarity:	105/269 - (39%)	Gaps:	87/269 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   434 FVSTNGLRHLHLDHNDIDLQQPLLDIMLQTQIN-------SPFGYMHGLLTLNLRNNSIIFVYND 491
            |.|..||:.:   ..||    |...::|:...|       ..|.::|
Human    49 FCSLRGLQEV---PEDI----PANTVLLKLDANKISHLPDGAFQHLH------------------ 88

  Fly   492 WKNTMLQLRELDLSYNNISSLGYEDLAFLSQNRLHVNMTHNKIRRIALPEDVHLGEGYNNNLVHV 556
                  :|||||||:|.|.::|....|.|:.....:::::|:|:||  |:|. ||:    ....:
Human    89 ------RLRELDLSHNAIEAIGSATFAGLAGGLRLLDLSYNRIQRI--PKDA-LGK----LSAKI 140

  Fly   557 DLNDNPLVCDCTI---LWFIQLVRGVHKPQYSRQFKLRTDRLVCSQPNVLEGTPVRQIEPQTLIC 618
            .|:.|||.|:|.:   ||.::|     .|.       ..|.:.|.       |.|::
Human   141 RLSHNPLHCECALQEALWELKL-----DPD-------SVDEIACH-------TSVQE-------- 178

  Fly   619 PLDFSDDPRERKCPRG---CNCHVRTYDKALVINC---HSGNLTHVPRLPNLHKNMQLMELHLEN 677
              :|...|..:....|   |:...||.|.|:::..   .:..:.:|  :..:..|.:....|||
Human   179 --EFVGKPLVQALDAGASLCSVPHRTTDVAMLVTMFGWFAMVIAYV--VYYVRHNQEDARRHLE- 238

  Fly   678 NTLLRLPSA 686
             .|..||||
Human   239 -YLKSLPSA 246

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tl	NP_001262995.1	LRR_8	174..233	CDD:290566
		leucine-rich repeat	176..198	CDD:275380
		leucine-rich repeat	199..222	CDD:275380
		LRR_RI	216..542	CDD:238064	28/114 (25%)
		LRR_8	221..281	CDD:290566
		leucine-rich repeat	223..270	CDD:275380
		leucine-rich repeat	271..294	CDD:275380
		leucine-rich repeat	295..320	CDD:275380
		leucine-rich repeat	321..343	CDD:275380
		LRR_8	342..402	CDD:290566
		leucine-rich repeat	344..367	CDD:275380
		leucine-rich repeat	368..391	CDD:275380
		LRR_8	390..450	CDD:290566	4/15 (27%)
		leucine-rich repeat	392..415	CDD:275380
		leucine-rich repeat	416..439	CDD:275380	2/4 (50%)
		leucine-rich repeat	440..474	CDD:275380	7/40 (18%)
		leucine-rich repeat	475..498	CDD:275380	0/22 (0%)
		LRR_8	477..534	CDD:290566	13/56 (23%)
		leucine-rich repeat	499..520	CDD:275380	11/20 (55%)
		leucine-rich repeat	523..552	CDD:275380	8/28 (29%)
		LRRCT	561..619	CDD:214507	13/60 (22%)
		LRRNT	631..667	CDD:214470	7/41 (17%)
		leucine-rich repeat	664..693	CDD:275380	9/23 (39%)
		LRR_8	669..726	CDD:290566	8/18 (44%)
		leucine-rich repeat	694..715	CDD:275380
		leucine-rich repeat	716..737	CDD:275380
		LRRCT	751..800	CDD:214507
		TIR	858..996	CDD:214587
LRRC3	NP_112153.1	LRRNT	32..68	CDD:214470	7/25 (28%)
		leucine-rich repeat	48..65	CDD:275378	7/22 (32%)
		LRR 1	65..86		3/20 (15%)
		leucine-rich repeat	66..89	CDD:275378	4/46 (9%)
		LRR_8	69..125	CDD:290566	17/79 (22%)
		LRR_4	69..103	CDD:289563	13/57 (23%)
		LRR_4	89..129	CDD:289563	16/41 (39%)
		LRR 2	89..110		10/20 (50%)
		leucine-rich repeat	90..114	CDD:275378	12/23 (52%)
		LRR 3	114..135		7/23 (30%)
		leucine-rich repeat	115..138	CDD:275378	8/29 (28%)
		LRR 4	136..157		6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000