Protein Alignment: Tl and LRRC3

• Sequence 1: NP_001262995.1
• Gene: Tl
• FlyBaseID: FBgn0262473
• Length: 1117
• Species: Drosophila melanogaster
• Sequence 2: NP_112153.1
• Gene: LRRC3
• HGNCID: 14965
• Length: 257
• Species: Homo sapiens
• Alignment Length: 269
• Identity: 63/270 (23%)
• Similarity: 105/270 (39%)
• Gaps: 87/270 (32%)

  Fly   434 FVSTNGLRHLHLDHNDIDLQQPLLDIMLQTQIN-------SPFGYMHGLLTLNLRNNSIIFVYND 491
            |.|..||:.:   ..||    |...::|:...|       ..|.::|
Human    49 FCSLRGLQEV---PEDI----PANTVLLKLDANKISHLPDGAFQHLH------------------ 88

  Fly   492 WKNTMLQLRELDLSYNNISSLGYEDLAFLSQNRLHVNMTHNKIRRIALPEDVHLGEGYNNNLVHV 556
                  :|||||||:|.|.::|....|.|:.....:::::|:|:||  |:|. ||:    ....:
Human    89 ------RLRELDLSHNAIEAIGSATFAGLAGGLRLLDLSYNRIQRI--PKDA-LGK----LSAKI 140

  Fly   557 DLNDNPLVCDCTI---LWFIQLVRGVHKPQYSRQFKLRTDRLVCSQPNVLEGTPVRQIEPQTLIC 618
            .|:.|||.|:|.:   ||.::|     .|.       ..|.:.|.       |.|::
Human   141 RLSHNPLHCECALQEALWELKL-----DPD-------SVDEIACH-------TSVQE-------- 178

  Fly   619 PLDFSDDPRERKCPRG---CNCHVRTYDKALVINC---HSGNLTHVPRLPNLHKNMQLMELHLEN 677
              :|...|..:....|   |:...||.|.|:::..   .:..:.:|  :..:..|.:....|||
Human   179 --EFVGKPLVQALDAGASLCSVPHRTTDVAMLVTMFGWFAMVIAYV--VYYVRHNQEDARRHLE- 238

  Fly   678 NTLLRLPSA 686
             .|..||||
Human   239 -YLKSLPSA 246

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tl	NP_001262995.1	LRR_8	174..233	CDD:290566
		leucine-rich repeat	176..198	CDD:275380
		leucine-rich repeat	199..222	CDD:275380
		LRR_RI	216..542	CDD:238064	28/115 (24%)
		LRR_8	221..281	CDD:290566
		leucine-rich repeat	223..270	CDD:275380
		leucine-rich repeat	271..294	CDD:275380
		leucine-rich repeat	295..320	CDD:275380
		leucine-rich repeat	321..343	CDD:275380
		LRR_8	342..402	CDD:290566
		leucine-rich repeat	344..367	CDD:275380
		leucine-rich repeat	368..391	CDD:275380
		LRR_8	390..450	CDD:290566	5/16 (31%)
		leucine-rich repeat	392..415	CDD:275380
		leucine-rich repeat	416..439	CDD:275380	2/5 (40%)
		leucine-rich repeat	440..474	CDD:275380	8/41 (20%)
		leucine-rich repeat	475..498	CDD:275380	0/23 (0%)
		LRR_8	477..534	CDD:290566	13/57 (23%)
		leucine-rich repeat	499..520	CDD:275380	11/21 (52%)
		leucine-rich repeat	523..552	CDD:275380	8/29 (28%)
		LRRCT	561..619	CDD:214507	13/61 (21%)
		LRRNT	631..667	CDD:214470	7/42 (17%)
		leucine-rich repeat	664..693	CDD:275380	9/24 (38%)
		LRR_8	669..726	CDD:290566	8/19 (42%)
		leucine-rich repeat	694..715	CDD:275380
		leucine-rich repeat	716..737	CDD:275380
		LRRCT	751..800	CDD:214507
		TIR	858..996	CDD:214587
LRRC3	NP_112153.1	LRRNT	32..68	CDD:214470	7/26 (27%)
		leucine-rich repeat	48..65	CDD:275378	7/23 (30%)
		LRR 1	65..86		3/21 (14%)
		leucine-rich repeat	66..89	CDD:275378	4/47 (9%)
		LRR_8	69..125	CDD:290566	17/80 (21%)
		LRR_4	69..103	CDD:289563	13/58 (22%)
		LRR_4	89..129	CDD:289563	16/42 (38%)
		LRR 2	89..110		11/21 (52%)
		leucine-rich repeat	90..114	CDD:275378	12/24 (50%)
		LRR 3	114..135		8/24 (33%)
		leucine-rich repeat	115..138	CDD:275378	8/30 (27%)
		LRR 4	136..157		6/21 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910		0.667	Consistency score
RoundUp	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910