DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tl and TLR4

DIOPT Version :10

Sequence 1:NP_001262995.1 Gene:Tl / 43222 FlyBaseID:FBgn0262473 Length:1117 Species:Drosophila melanogaster
Sequence 2:NP_612564.1 Gene:TLR4 / 7099 HGNCID:11850 Length:839 Species:Homo sapiens


Alignment Length:906 Identity:221/906 - (24%)
Similarity:352/906 - (38%) Gaps:262/906 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   257 IEQLPHDVFAHLTNVTDINLSANLFRSLPQGLFDHNKHLNEVRLMNNRVPLATLPSRLFANQPEL 321
            :|.:|        |:|...:..|.:: :|..|....|:|:   |..|  ||..|.|..|.:.|||
Human    30 VEVVP--------NITYQCMELNFYK-IPDNLPFSTKNLD---LSFN--PLRHLGSYSFFSFPEL 80

  Fly   322 QILRL-RAELQSLPGDLFEHSTQITNISLGDNLLKTLPATLLEHQVNLLSLDLSNNRLTHLPDSL 385
            |:|.| |.|:|::....::..:.::.:.|..|.:::|.........:|..|......|..|.:..
Human    81 QVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPIQSLALGAFSGLSSLQKLVAVETNLASLENFP 145

  Fly   386 FAHTTNLTDLRLEDNLLTGIS-GDIFSNLGNLVTLVMSRNRLRTIDSRAFVSTNGLRHLHLDHND 449
            ..|...|.:|.:..||:.... .:.||||.||..|.:|.|::::|      ....||.||     
Human   146 IGHLKTLKELNVAHNLIQSFKLPEYFSNLTNLEHLDLSSNKIQSI------YCTDLRVLH----- 199

  Fly   450 IDLQQPLLDIMLQTQINSPFGYMH-------GLLTLNLRNN----SII--------------FVY 489
               |.|||::.|...:| |..::.       .|..|.||||    :::              .|.
Human   200 ---QMPLLNLSLDLSLN-PMNFIQPGAFKEIRLHKLTLRNNFDSLNVMKTCIQGLAGLEVHRLVL 260

  Fly   490 NDWKN---------------TMLQLRELDLSY---------------NNISSLGYEDLAFLSQNR 524
            .:::|               ..|.:.|..|:|               .|:||...          
Human   261 GEFRNEGNLEKFDKSALEGLCNLTIEEFRLAYLDYYLDDIIDLFNCLTNVSSFSL---------- 315

  Fly   525 LHVNMTHNKIRRIALPEDVHLGEGYNNNLVHVDLNDNPLVCDCTILWFIQLVRGVHKPQYSRQFK 589
              |::|..:::..:          ||....|::|      .:|....|..|             |
Human   316 --VSVTIERVKDFS----------YNFGWQHLEL------VNCKFGQFPTL-------------K 349

  Fly   590 LRTDRLVCSQPNVLEGTPVRQIEPQTLICPLDFSDDPRERKCPRGCNCHVRTYD----KALVINC 650
            |::.:.:....| ..|....:::    :..|:|.|..|.....:|| |....:.    |.|.::.
Human   350 LKSLKRLTFTSN-KGGNAFSEVD----LPSLEFLDLSRNGLSFKGC-CSQSDFGTTSLKYLDLSF 408

  Fly   651 H-----SGNLTHVPRLPNL---HKNMQLME-----LHLENNTLLRLPSANT--------PGYESV 694
            :     |.|...:.:|.:|   |.|::.|.     |.|.|...|.:...:|        .|..|:
Human   409 NGVITMSSNFLGLEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSL 473

  Fly   695 TSLHLAGN---------------NLTSIDVDQL------PT-----------NLTH--------- 718
            ..|.:|||               |||.:|:.|.      ||           |::|         
Human   474 EVLKMAGNSFQENFLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTF 538

  Fly   719 ----------LDISWNHL-----QMLN--ATVLGFLNRTMKWRSVKLSGNPWMCDCTAKPLLLFT 766
                      ||.|.||:     |.|.  .:.|.|||         |:.|.:.|.|..:..|.:.
Human   539 PYKCLNSLQVLDYSLNHIMTSKKQELQHFPSSLAFLN---------LTQNDFACTCEHQSFLQWI 594

  Fly   767 QDNFERIGDRNEMMCVNAEMPTRMVELSTNDICPAEKGVFIALAVVIALTGLLAGFTAALYYKFQ 831
            :|..:.:.:...|.|........|..||.|..|...|.: |.::|   |:.|:....|.|.||| 
Human   595 KDQRQLLVEVERMECATPSDKQGMPVLSLNITCQMNKTI-IGVSV---LSVLVVSVVAVLVYKF- 654

  Fly   832 TEIKIWLYAHNLLL----WFVTEEDLDKDKKFDAFISYSHKDQSFIEDYLVPQLEHGPQKFQLCV 892
                   |.|.:||    .:...|::     :|||:.||.:|:.::.:.||..||.|...||||:
Human   655 -------YFHLMLLAGCIKYGRGENI-----YDAFVIYSSQDEDWVRNELVKNLEEGVPPFQLCL 707

  Fly   893 HERDWLVGGHIPENIM-RSVADSRRTIIVLSQNFIKSEWARLEFRAAHRSALNEGRSRIIVIIYS 956
            |.||::.|..|..||: .....||:.|:|:||:||:|.|...|:..|........|:.||.|:  
Human   708 HYRDFIPGVAIAANIIHEGFHKSRKVIVVVSQHFIQSRWCIFEYEIAQTWQFLSSRAGIIFIV-- 770

  Fly   957 DIGDVEK--LDEELKAY--LKMNTYLKWGDP-----WFWDKLRFALPHRR---PVGNIGNG 1005
             :..|||  |.::::.|  |..||||:|.|.     .||.:||.||...:   |.|.:|.|
Human   771 -LQKVEKTLLRQQVELYRLLSRNTYLEWEDSVLGRHIFWRRLRKALLDGKSWNPEGTVGTG 830

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TlNP_001262995.1 LRR_8 174..233 CDD:404697
leucine-rich repeat 176..198 CDD:275380
leucine-rich repeat 199..222 CDD:275380
LRR 222..576 CDD:443914 81/375 (22%)
leucine-rich repeat 223..270 CDD:275380 2/12 (17%)
leucine-rich repeat 271..294 CDD:275380 4/22 (18%)
leucine-rich repeat 295..320 CDD:275380 8/24 (33%)
leucine-rich repeat 321..343 CDD:275380 7/22 (32%)
leucine-rich repeat 344..367 CDD:275380 3/22 (14%)
leucine-rich repeat 368..391 CDD:275380 5/22 (23%)
leucine-rich repeat 392..415 CDD:275380 8/23 (35%)
leucine-rich repeat 416..439 CDD:275380 5/22 (23%)
leucine-rich repeat 440..474 CDD:275380 11/40 (28%)
leucine-rich repeat 475..498 CDD:275380 8/55 (15%)
leucine-rich repeat 499..520 CDD:275380 6/35 (17%)
leucine-rich repeat 523..552 CDD:275380 4/28 (14%)
LRRCT 561..619 CDD:214507 7/57 (12%)
LRRNT 631..667 CDD:214470 10/47 (21%)
PPP1R42 <660..752 CDD:455733 37/165 (22%)
leucine-rich repeat 664..693 CDD:275380 10/44 (23%)
leucine-rich repeat 694..715 CDD:275380 11/52 (21%)
leucine-rich repeat 716..737 CDD:275380 9/46 (20%)
LRRCT 751..800 CDD:214507 11/48 (23%)
TIR 858..996 CDD:214587 56/147 (38%)
TLR4NP_612564.1 LRR 1 55..76 9/25 (36%)
leucine-rich repeat 56..79 CDD:275378 9/27 (33%)
LRR_8 57..114 CDD:404697 20/61 (33%)
PPP1R42 76..>190 CDD:455733 30/113 (27%)
LRR 2 79..100 8/20 (40%)
leucine-rich repeat 80..103 CDD:275378 7/22 (32%)
LRR 3 103..124 3/20 (15%)
leucine-rich repeat 104..127 CDD:275378 3/22 (14%)
LRR 4 127..148 4/20 (20%)
leucine-rich repeat 128..176 CDD:275378 13/47 (28%)
leucine-rich repeat 130..151 CDD:275380 4/20 (20%)
LRR 5 151..172 4/20 (20%)
LRR 6 176..199 8/28 (29%)
leucine-rich repeat 177..190 CDD:275378 4/12 (33%)
leucine-rich repeat 195..224 CDD:275380 11/37 (30%)
LRR 7 205..225 3/20 (15%)
LRR 8 227..247 6/19 (32%)
LRR 290..>581 CDD:443914 67/346 (19%)
LRR 9 331..351 6/38 (16%)
LRR 10 352..373 2/25 (8%)
leucine-rich repeat 353..374 CDD:275380 2/25 (8%)
LRR 11 374..394 7/20 (35%)
LRR 12 400..422 4/21 (19%)
leucine-rich repeat 401..423 CDD:275380 4/21 (19%)
LRR 13 423..444 5/20 (25%)
leucine-rich repeat 424..448 CDD:275380 7/23 (30%)
LRR 14 448..456 2/7 (29%)
leucine-rich repeat 449..472 CDD:275380 3/22 (14%)
LRR 15 472..495 5/22 (23%)
leucine-rich repeat 473..497 CDD:275380 4/23 (17%)
LRR 16 497..518 7/20 (35%)
leucine-rich repeat 498..521 CDD:275380 6/22 (27%)
LRR 17 521..542 2/20 (10%)
LRR 18 545..565 6/19 (32%)
leucine-rich repeat 546..570 CDD:275380 7/23 (30%)
LRRCT 579..625 CDD:214507 10/45 (22%)
TIR 674..815 CDD:214587 54/143 (38%)
Blue background indicates that the domain is not in the aligned region.

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