DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tl and TLR3

DIOPT Version :10

Sequence 1:NP_001262995.1 Gene:Tl / 43222 FlyBaseID:FBgn0262473 Length:1117 Species:Drosophila melanogaster
Sequence 2:NP_003256.1 Gene:TLR3 / 7098 HGNCID:11849 Length:904 Species:Homo sapiens


Alignment Length:1004 Identity:227/1004 - (22%)
Similarity:405/1004 - (40%) Gaps:235/1004 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   121 YLGIVSPTTLIFESDNLGMNITRQHLDRLHGLKRFRFTTRRLTHIPANLLTDMR--NLSHLELRA 183
            :.|.:.|..::..|......::.:..|..|         .:||.:|.:|.|::.  ||:|.:|| 
Human    10 FWGGLLPFGMLCASSTTKCTVSHEVADCSH---------LKLTQVPDDLPTNITVLNLTHNQLR- 64

  Fly   184 NIEEMPSHLFDDLENLESIEFGSNKLRQMPRGIFGKMPKLKQLNLWSNQLHNLTKHDFEGATSVL 248
               .:|:..|.....|.|::.|.|.:.::...:..|:|.||.|||..|:|..|:...|...|::.
Human    65 ---RLPAANFTRYSQLTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLT 126

  Fly   249 GIDIHDNGIEQLPHDVFAHLTNVTDINLSANLFRSLPQGLFDHNKHLNEVRLMNNRV-PLATLPS 312
            .:.:..|.|:::.::.|....|:..::||.|...|...|.....::|.|:.|.||:: .|.:...
Human   127 ELHLMSNSIQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQALKSEEL 191

  Fly   313 RLFANQPELQILRLRAE--LQSLPG---------DLFEHSTQITNISLGDNLLKTLPATLLEHQV 366
            .:|||. .|:.|.|.:.  .:..||         .||     :.|:.||.:|.:.|...|.  ..
Human   192 DIFANS-SLKKLELSSNQIKEFSPGCFHAIGRLFGLF-----LNNVQLGPSLTEKLCLELA--NT 248

  Fly   367 NLLSLDLSNNRLTHLPDSLF--AHTTNLTDLRLEDNLLTGISGDIFSNLGNLVTLVMSRNRLRTI 429
            ::.:|.|||::|:...::.|  ...||||.|.|..|.|..:..|.|:.|..|....:..|.::.:
Human   249 SIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHL 313

  Fly   430 DSRAFVSTNGLRHLHLDHN----DIDLQQ-PLLDIMLQTQINSPFGYMHGLLTLNLRNNSIIFVY 489
            .|.:......:|:|:|..:    .|.|.. |.:|       :..|.::..|..||:.:|.|..:.
Human   314 FSHSLHGLFNVRYLNLKRSFTKQSISLASLPKID-------DFSFQWLKCLEHLNMEDNDIPGIK 371

  Fly   490 NDWKNTMLQLRELDL--SYNNISSLGYEDLAFLSQNRLHV-NMTHNKIRRIALPEDVHLGE---- 547
            ::....::.|:.|.|  |:.::.:|..|....|:.:.||: |:|.|||.:|.......||.    
Human   372 SNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVL 436

  Fly   548 --GYN--------------NNLVHVDLNDNPLVCDCTILWFIQLVRGVHK--PQYSRQFKLRTDR 594
              |.|              .|:..:.|:.|.         ::||.|....  |...| ..||...
Human   437 DLGLNEIGQELTGQEWRGLENIFEIYLSYNK---------YLQLTRNSFALVPSLQR-LMLRRVA 491

  Fly   595 L--VCSQPNVLEGTPVRQIEPQTLICPLDFSDDPRERKCPRGCNCHVRTYDKALVINCHSGNLTH 657
            |  |.|.|:..:  |:|.:   |:   ||.|::                                
Human   492 LKNVDSSPSPFQ--PLRNL---TI---LDLSNN-------------------------------- 516

  Fly   658 VPRLPNLHKNM-----QLMELHLENNTLLRLPSANTPG-----YESVTSLHLAGNNLTSIDVDQL 712
              .:.|::.:|     :|..|.|::|.|.||.....||     .:.::.||:.  ||.|...|::
Human   517 --NIANINDDMLEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHIL--NLESNGFDEI 577

  Fly   713 PT-------NLTHLDISWNHLQMLNATVLGFLNRTMKWRSVKLSG-------------------- 750
            |.       .|..:|:..|:|..|.|:|   .|..:..:|:.|..                    
Human   578 PVEVFKDLFELKIIDLGLNNLNTLPASV---FNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLTE 639

  Fly   751 -----NPWMCDCTAKPLLLF------TQDNFERIGDRNEMMCVNAE----MPTRMVELST-NDIC 799
                 ||:  |||.:.:..|      |..|...:.  :..:|....    .|.|:.:.|: .|..
Human   640 LDMRFNPF--DCTCESIAWFVNWINETHTNIPELS--SHYLCNTPPHYHGFPVRLFDTSSCKDSA 700

  Fly   800 PAEKG---------VFIALAVVIALTGLLAGFTAALYYKFQTEIKIWLYAHNLLLWFVTEEDLDK 855
            |.|..         :||.:.::|...|....|             .|..:.:.:|.|   :::|:
Human   701 PFELFFMINTSILLIFIFIVLLIHFEGWRISF-------------YWNVSVHRVLGF---KEIDR 749

  Fly   856 DK---KFDAFISYSHKDQSFIEDYLVPQLEHGPQKFQLCVHERDWLVGGHIPENIMRSVADSRRT 917
            ..   ::.|:|.:::||:.::.::. ..:|...|..:.|:.|||:..|....|.|:.|:..||:.
Human   750 QTEQFEYAAYIIHAYKDKDWVWEHF-SSMEKEDQSLKFCLEERDFEAGVFELEAIVNSIKRSRKI 813

  Fly   918 IIVLSQNFIKSEWARLEFRAAH--RSALNEGRSRIIVIIYSDIGDVEKLDEEL---KAYLKMNTY 977
            |.|::.:.:|....: .|:..|  :.|:.:....||::...:|.|. ||:..|   :...|.:..
Human   814 IFVITHHLLKDPLCK-RFKVHHAVQQAIEQNLDSIILVFLEEIPDY-KLNHALCLRRGMFKSHCI 876

  Fly   978 LKWGDP-------WFWDKLRFALPHRRPV 999
            |.|  |       .|..||:.||..:..|
Human   877 LNW--PVQKERIGAFRHKLQVALGSKNSV 903

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TlNP_001262995.1 LRR_8 174..233 CDD:404697 19/60 (32%)
leucine-rich repeat 176..198 CDD:275380 6/21 (29%)
leucine-rich repeat 199..222 CDD:275380 5/22 (23%)
LRR 222..576 CDD:443914 97/395 (25%)
leucine-rich repeat 223..270 CDD:275380 13/46 (28%)
leucine-rich repeat 271..294 CDD:275380 5/22 (23%)
leucine-rich repeat 295..320 CDD:275380 9/25 (36%)
leucine-rich repeat 321..343 CDD:275380 7/32 (22%)
leucine-rich repeat 344..367 CDD:275380 6/22 (27%)
leucine-rich repeat 368..391 CDD:275380 6/24 (25%)
leucine-rich repeat 392..415 CDD:275380 9/22 (41%)
leucine-rich repeat 416..439 CDD:275380 3/22 (14%)
leucine-rich repeat 440..474 CDD:275380 8/38 (21%)
leucine-rich repeat 475..498 CDD:275380 5/22 (23%)
leucine-rich repeat 499..520 CDD:275380 6/22 (27%)
leucine-rich repeat 523..552 CDD:275380 12/49 (24%)
LRRCT 561..619 CDD:214507 15/61 (25%)
LRRNT 631..667 CDD:214470 1/35 (3%)
PPP1R42 <660..752 CDD:455733 28/133 (21%)
leucine-rich repeat 664..693 CDD:275380 10/38 (26%)
leucine-rich repeat 694..715 CDD:275380 7/27 (26%)
leucine-rich repeat 716..737 CDD:275380 7/20 (35%)
LRRCT 751..800 CDD:214507 13/59 (22%)
TIR 858..996 CDD:214587 38/149 (26%)
TLR3NP_003256.1 leucine-rich repeat 33..52 CDD:275380 6/27 (22%)
LRR <36..309 CDD:443914 79/293 (27%)
LRR 1 52..73 7/24 (29%)
leucine-rich repeat 53..76 CDD:275380 7/26 (27%)
LRR 2 76..97 4/20 (20%)
leucine-rich repeat 77..100 CDD:275380 5/22 (23%)
LRR 3 100..121 9/20 (45%)
leucine-rich repeat 101..124 CDD:275380 9/22 (41%)
LRR 4 124..145 3/20 (15%)
leucine-rich repeat 125..148 CDD:275380 3/22 (14%)
LRR 5 148..168 6/19 (32%)
leucine-rich repeat 149..198 CDD:275380 14/49 (29%)
LRR 6 172..193 6/20 (30%)
LRR 7 198..219 5/20 (25%)
leucine-rich repeat 199..249 CDD:275380 13/56 (23%)
LRR 8 222..244 7/26 (27%)
LRR 9 249..270 6/20 (30%)
leucine-rich repeat 250..275 CDD:275380 6/24 (25%)
LRR 10 275..296 9/20 (45%)
leucine-rich repeat 276..299 CDD:275380 9/22 (41%)
LRR 284..>630 CDD:443914 88/409 (22%)
LRR 11 299..320 3/20 (15%)
leucine-rich repeat 300..321 CDD:275380 3/20 (15%)
LRR 12 323..344 5/20 (25%)
LRR 13 356..377 5/20 (25%)
leucine-rich repeat 357..380 CDD:275380 5/22 (23%)
LRR 14 380..400 5/19 (26%)
leucine-rich repeat 381..406 CDD:275380 7/24 (29%)
LRR 15 408..429 8/20 (40%)
leucine-rich repeat 409..432 CDD:275380 9/22 (41%)
LRR 16 432..454 2/21 (10%)
leucine-rich repeat 433..457 CDD:275380 2/23 (9%)
leucine-rich repeat 458..481 CDD:275380 5/31 (16%)
LRR 17 465..486 6/30 (20%)
leucine-rich repeat 482..507 CDD:275380 8/27 (30%)
LRR 18 507..528 6/60 (10%)
leucine-rich repeat 508..531 CDD:275380 6/62 (10%)
LRR 19 531..552 7/20 (35%)
leucine-rich repeat 532..563 CDD:275380 9/30 (30%)
LRR 20 563..584 7/22 (32%)
leucine-rich repeat 564..585 CDD:275380 7/22 (32%)
LRR 21 587..608 7/23 (30%)
leucine-rich repeat 588..611 CDD:275380 8/25 (32%)
LRR 22 611..632 2/20 (10%)
leucine-rich repeat 612..630 CDD:275380 2/17 (12%)
leucine-rich repeat 637..659 CDD:275380 6/23 (26%)
LRRCT 645..697 CDD:214507 12/55 (22%)
Tlr3_TMD 698..730 CDD:465595 7/31 (23%)
TIR 755..900 CDD:214587 38/149 (26%)

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